Epidural Block Impairs HPV During One-lung Ventilation: an EIT- Based Prospective Observation Study
Epidural Block Impairs Hypoxic Pulmonary Vasoconstriction During One-lung Ventilation: an Electrical Impedance Tomography- Based Prospective Observation Study
1 other identifier
observational
50
1 country
1
Brief Summary
Define the effect of epidural block on HPV by EIT.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2020
CompletedFirst Submitted
Initial submission to the registry
January 25, 2021
CompletedFirst Posted
Study publicly available on registry
January 29, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2022
CompletedJanuary 29, 2021
January 1, 2021
2 years
January 25, 2021
January 25, 2021
Conditions
Outcome Measures
Primary Outcomes (2)
Assess regional distribution of pulmonary perfusion
To evaluate the effect of epidural block on pulmonary blood flow distribution.
within 24 hours
Assess oxygenation status
To evaluate the effect of epidural block by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated.
within 24 hours
Interventions
A bolus of 10ml 10% NaCl was injected during a respiratory pause (≥10s) through the central venous catheter.The results of arterial blood gas analysis and the data of EIT were collected before the first prone session (time baseline), the end of prone positioning (time P).
Eligibility Criteria
Patients requiring thoracic surgery are given combined epidural anesthesia.
You may qualify if:
- Age 18 - 80 years Existing central venous and arterial access Chest circumference 70 - 150 cm
You may not qualify if:
- Contraindication to central venous injection of 5 % sodium chloride (NaCl)
- Contraindications of PulmoVista 500:
- Patients with pacemakers, defibrillators or other electrically active implants Patients with damaged skin or impaired skin contact of the electrodes due to wound dressings Patients where the attachment of the patient belt could pose a risk to the patient, e.g. patients with spinal lesions or fractures Patients with uncontrolled body movements Extremely obese patients (BMI\>50) Patients during pregnancy Patients with massive lung edema Use during electricity-based therapies, such as electrosurgery or electrocautery Use in the presence of strong magnetic fields Use in conjunction with other bioimpedance measurement devices
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhongshan Hospital of Fudan University
Shanghai, Shanghai Municipality, 200032, China
Related Publications (1)
Wang Y, Wei Y, Chen G, Wang Z, Fan Y, Wang J, Yang Y, Zhou D, Zhong M. The effects of thoracic epidural blockade on ventilation-perfusion matching during one-lung ventilation: An exploratory study. J Clin Anesth. 2024 Dec;99:111678. doi: 10.1016/j.jclinane.2024.111678. Epub 2024 Nov 6.
PMID: 39504921DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Ming Zhong, MD, phD
Fudan University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
January 25, 2021
First Posted
January 29, 2021
Study Start
August 1, 2020
Primary Completion
July 31, 2022
Study Completion
July 31, 2022
Last Updated
January 29, 2021
Record last verified: 2021-01