Comparing Electrical Impedance Tomography to Computed Tomographic Angiography

NCT05546333 | Active Not Recruiting

• 1 other identifier: 21-4600
• Study Type: observational
• Target: 63
• Locations: 1 country
• Sites: 1

Brief Summary

The study aim is to determine whether electrical impedance tomography (EIT) is equivalent in the detection of pulmomary emboli compared to Computed Tomographic Angiography (CTA). EIT is a non-invasive, non-ionizing functional imaging technique that can be performed at bedside. Electrical impedance tomography data will be collected on individuals undergoing a CTA scan of the chest at Medical Center of the Rockies (MCR). The primary outcome measure is to assess whether assessment by CTA corresponds with EIT in detection of pulmonary emboli. The study will include up to 63 participants. EIT data will be collected for up to 20 minutes during tidal breathing and for approximately five to ten seconds during breath-holding.

Conditions

Pulmonary Embolism

Outcome Measures

Primary Outcomes (1)

• Correspondence to CTA

  To assess whether assessment by CTA corresponds with EIT in detection of pulmonary emboli (PE).

  One year

Study Arms (1)

Patients receiving CTA

Patients who will receive a CTA due to clinical need will be imaged with electrical impedance tomography in addition to the CTA.

Device: Electrical impedance tomography

Interventions

Electrical impedance tomography DEVICE

Non-invasive measure of electrical impedance in the body, with data collected on electrodes on the surface of the body

Also known as: EIT

Patients receiving CTA

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Individuals undergoing a CTA scan of the chest at Medical Center of the Rockies (MCR) for a suspected pulmonary embolism

You may qualify if:

• years of age or older
• Undergoing a CTA of the chest at MCR

You may not qualify if:

• Under 18 years of age
• Body mass index (BMI) \> 30
• Individuals with known thoracic metal implants or devices, such as pacemakers (internal and external), staples, or spinal and rib hardware
• Individuals deemed by the research team as too unstable to safely apply the EIT belt, such as hemodynamic or respiratory instability (e.g., intubated patients), and individuals with unstable spinal injuries
• Open wounds at the site of electrode belt application

Sponsors & Collaborators

• Colorado State University: lead
• UC Health Medical Center of the Rockies: collaborator

Study Sites (1)

UCHealth Medical Center of the Rockies

Loveland, Colorado, 80538, United States

Location

MeSH Terms

Conditions

Pulmonary Embolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Jennifer L Mueller, PhD

  Colorado State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 15, 2022
• First Posted: September 19, 2022
• Study Start: May 1, 2023
• Primary Completion: May 23, 2024
• Study Completion (Estimated): June 9, 2026
• Last Updated: June 11, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)