Electrical Impedance Tomography: Collapse in Dependent Areas as a Predictor of Response to Prone Position Ventilation in COVID-19 Acute Respiratory Distress Syndrome
COVIDEIT
2 other identifiers
observational
50
1 country
2
Brief Summary
There are several clinical presentations of SARS-CoV-2 infection. Among the severe forms, pulmonary involvement with respiratory failure is common. Although severe lung involvement with SARS-CoV-2 meets the Berlin criteria for Acute Respiratory Distress Syndrome (ARDS), it differs from classic ARDS in that compliance (reflecting distensibility of the lung parenchyma) is frequently preserved. If the interest of Electrical Impedance Tomography has been demonstrated in classical ARDS, this is not the case in ARDS with COVID-19. However, the use of this technique in this particular patient population would make it possible to distinguish patients with severe hypoxemia linked to derecruitment from those without derecruitment, in whom hypoxemia is more likely to be linked to the loss of hypoxic vasoconstriction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2020
Shorter than P25 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 24, 2020
CompletedStudy Start
First participant enrolled
October 26, 2020
CompletedFirst Posted
Study publicly available on registry
October 27, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 18, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 18, 2021
CompletedSeptember 16, 2021
September 1, 2021
5 months
October 24, 2020
September 14, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Coefficient of correlation between the percentage of derecruitment of dependent areas (measured with Electrical Impedance Tomography) and the response to prone position
The percentage of derecruitment of dependent areas will be measured every day with Electrical Impedance Tomography. The response to prone position will be assessed every day.
Up to 7 days
Interventions
Electrical Impedance tomography recording during 5 minutes every day during 7 days
Eligibility Criteria
The study population is composed of patients who have been admitted to the intensive care unit for SARS-CoV-2 ARDS.
You may qualify if:
- Patients admitted to the intensive care unit for SARS-CoV-2 ARDS
- Under controlled invasive ventilation for less than 7 days
You may not qualify if:
- Pneumothorax
- Deformation of the rib cage
- Contraindication to Electrical Impedance Tomography
- Pregnant or breastfeeding woman
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Hôpital de la Timone
Marseille, 13005, France
Hôpital d'Instruction des Armées Sainte-Anne
Toulon, 83800, France
Related Publications (1)
Cardinale M, Boussen S, Cungi PJ, Esnault P, Mathais Q, Bordes J, Meaudre E, Goutorbe P. Lung-Dependent Areas Collapse, Monitored by Electrical Impedance Tomography, May Predict the Oxygenation Response to Prone Ventilation in COVID-19 Acute Respiratory Distress Syndrome. Crit Care Med. 2022 Jul 1;50(7):1093-1102. doi: 10.1097/CCM.0000000000005487. Epub 2022 Feb 11.
PMID: 35200196DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 24, 2020
First Posted
October 27, 2020
Study Start
October 26, 2020
Primary Completion
March 18, 2021
Study Completion
March 18, 2021
Last Updated
September 16, 2021
Record last verified: 2021-09