Air Pollution and Daily Mobility of Pregnant Women Identification of Critical Windows of Exposure

NCT04725734 | Unknown

• 1 other identifier: 8000
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

This study is conducted to assess the role of pregnant women's daily mobility living in the Eurometropole of Strasbourg in a context of the existence of environmental exposure disparities (PM10, PM2.5, NO2). Furthermore, this study will tend to identify the critical windows of exposure and of greater risk of the adverse pregnancy outcomes as low birth weight and prematurity. A second question addressed in this work is to assess the relationship between the pregnant women's socio-economic status and the air pollution exposure (PM10, PM2.5, NO2).taking into account the spatio-temporal variations of the exposure as well as the critical windows of exposure during pregnancy. The present work deals with the following question "how does the combination of environmental exposure, socio-economic status and women's daily mobility, could contribute to socio-spatial inequalities in the health of the newborn? The underlying hypothesis is that the accumulation, in given area, of environmental exposures (as PM10, PM2.5 and NO2), of unfavorable living conditions (socio-economic environment) and individual factors (specific spatio-temporal trajectory) would induce an increased risk for the health of the newborn, (more particularly in terms of birth weight and term of birth). This hypothesis is structured 4 sub-hypotheses: i) The misclassification of exposure is socially distributed among pregnant women living in the Eurometropole of Strasbourg. ii) Beyond maternal and fetal characteristics, pregnant women who reside in a more socio-economically deprived neighborhood and / or with higher levels of environmental exposure to PM10, PM2.5 and NO2 are more at risk of preterm newborn and low birth weight newborn. iii) The accumulation of environmental exposures of the pregnant women and their daily mobility over their territory during the pregnancy increase the health inequalities of the newborn. iv) The critical windows of fetal exposure to pollutants is related to the socioeconomic level of their neighborhood and to the daily mobility of the women in their territory during pregnancy. Women are included in the study at the time of their first or second trimester ultrasound. Here are the tools used in the study: Descriptive survey of their idividuals characteristics, descriptive survey of women's mobility to assess their exposure during each trimester of pregnancy.

Conditions

Pregnancy; Low Birth Weight; Preterm Birth; Air Pollution

Keywords

social inequalities

Outcome Measures

Primary Outcomes (2)

• Characteristics of the newborn

  Estimation of fetal weight

  7 months

• Characteristics of the newborn

  Estimation of birth weight

  7 months

Interventions

Pregnant women OTHER

The patients will complete a questionnaire for each quarter

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women, include at 1st or 2nd trimester in the Hautepierre and CMCO ultrasound department. The period of inclusion should extend from 1 October 2020 to 31 October 2021 with a duration of participation of each subject of 9 months.

You may qualify if:

• Pregnant women dwelling in the Eurometropole of Strasbourg
• Women who have done ultrasound monitoring in the HUS (Hopitaux Universitaires de Strasbourg)
• Good understanding of the French language
• Women who give her signed agreement of non-opposition to research and / or who give her signed consent for the data collect
• refusal to participate in the study
• under-age women (\<18 years old)
• women who not have a clear understanding of the information (emergency situation, comprehension problems…)
• Women must not be under tutorship or curatorship or under the protection of a conservator ("sauvegarde de justice")

You may not qualify if:

• premature delivery threats
• placenta previa
• twin pregnancy
• pre-eclampsia

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Les Hôpitaux Universitaires de Strasbourg

Schiltigheim, 67303, France

RECRUITING

Related Publications (1)

• Simoncic V, Hamann V, Huber L, Deruelle P, Sananes N, Enaux C, Alter M, Schillinger C, Deguen S, Kihal-Talantikite W. Study protocol to explore the social effects of environmental exposure and lifestyle behaviours on pregnancy outcome: an overview of cohort of pregnant women study. BMJ Open. 2022 Sep 17;12(9):e058883. doi: 10.1136/bmjopen-2021-058883.

  PMID: 36115665 DERIVED

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Virginie HAMANN

  Les Hôpitaux Universitaires

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Virginie HAMANN

CONTACT

+ 3 69 55 43 93; virginie.hamann@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 5, 2020
• First Posted: January 27, 2021
• Study Start: February 4, 2021
• Primary Completion: February 4, 2021
• Study Completion: January 1, 2022
• Last Updated: April 1, 2021

Record last verified: 2021-03

Locations

FR (1)