Impacts of Sugar-Sweetened Beverage on Body Weight

NCT04723082 | Completed

• 1 other identifier: 2-078-20
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

The obesity epidemic is a major public health problem. Weight gain is strongly associated with an increase in the incidence of complex health conditions such as type 2 diabetes (T2D), cardiovascular disease, stroke, and cancers. Behaviours linked to food and beverage consumption can greatly affect body weight. Frequent consumption of sugar-sweetened beverages such as carbonated soft-drinks, energy and sport drinks, fruit juices from concentrate, soda and flavoured milk and water is considered to be an unhealthy dietary behaviour. This project will investigate how variations in an individual's genes may impact their consumption of SSBs and thus body fatness. Specifically, the project will aim to investigate whether genetic variation in the taste receptors TAS1R2 and TAS1R3 can influence an individuals' perception and liking of a sweet palate and their intake of SSBs in UK. This study will be an experimental study that evaluates human body composition by different measurements. Additionally, two different biomarkers will be used for the study, such as blood and urine samples. Blood samples are the preferred source for DNA testing, rather than saliva. Urine samples will be used to look at the sugar level in the human body as a measure of body composition using deuterium dilution techniques. Around 128 adult volunteers will be recruited from Aberdeen, UK to participate in the study, which will take approximately one week to complete for each individual.

Conditions

Obesity

Keywords

Body fatness; Sweet taste receptors; Sugar-sweetened beverage

Outcome Measures

Primary Outcomes (1)

• To establish the correlation between consumption of SSBs and body fatness.

  Consumption of SSBs and other factors such as dietary behaviour and sociodemographic were examined previously among children and adults. Excessive consumption of SSBs in children, adolescents and adults strongly contribute to an increased risk of developing several health conditions. Statistical data that has been collected over time show the association between the consumption of SSBs and increased body weight.

  6 months

Secondary Outcomes (1)

• This research will reveal the relationship between genetic variation of taste receptors in UK adults linked with their sweet taste preferences and consumption of SSBs.

  6 months

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

About 128 healthy adult volunteers are required to participate in the study. They need to be living in Aberdeen City or Aberdeenshire. Participants will be requited by flyers distributing from the public who live in Aberdeen city and Aberdeenshire. Also, from the Energetics research group account on twitter. Participants will volunteer to take part independently.

You may qualify if:

• Healthy men and women (with no known significant health problems)
• years and older (The form required me to put the maximum age, which is not stated in the protocol, so I put 100)

You may not qualify if:

• Less than 18 years
• Diabetic individuals
• Not living in Aberdeen city or shire
• Pregnant women
• Non-English speaker and non-able to read and understand study information sheet.

Sponsors & Collaborators

• University of Aberdeen: lead

Study Sites (1)

The Rowett Institute, University of Aberdeen

Aberdeen, AB25 2ZD, United Kingdom

Location

Related Links

• Genetic variation in TAS1R2
• Human sweet taste, the perception and intake of sweet
• Variation in the human TAS1R
• sweetened beverage consumption

Biospecimen

Retention: SAMPLES WITH DNA

We collected blood and urine samples. The researcher acknowledges the risks and ethical issues of taking biological samples, wearing correct PPE, and following the procedures for collection and handling samples. Participants will be fully aware of the study process via the PIS.

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Catherine Hambly, PhD

  University of Aberdeen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2021
• First Posted: January 25, 2021
• Study Start: September 10, 2021
• Primary Completion: July 22, 2022
• Study Completion: July 22, 2022
• Last Updated: December 13, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: In line with MRC regulations all data will be stored for 10 years.
• Access Criteria: Individual participant data (after de-identification) that underlie the results of this study will be available upon reasonable requests to investigators whose proposed used of data has been approved by an independent review committee identified for this purpose.

Locations

GB (1)