Internet-administered Interpersonal Psychotherapy for Depressive Symptoms

NCT04721678 | Completed

• 1 other identifier: INDIGO
• Study Type: interventional
• Target: 113
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to test the efficacy of a treatment for depression based on interpersonal psychotherapy (IPT). The treatment will be accessed via an internet platform built for this study. A therapist will provide support weekly, as well as on-demand when needed. The treatment lasts for 10 weeks.

Conditions

Major Depressive Disorder

Keywords

Interpersonal Psychotherapy; Major Depressive Disorder; Internet Intervention; Internet-based psychotherapy

Outcome Measures

Primary Outcomes (1)

• Change on Montgomery Åsberg Depression Rating Scale (MADRS-S)

  Depression inventory, consists of 9 items measuring symptoms of major depressive disorder. Each item are scored between 0 and 6 points, resulting in a total sum between 0 and 54. Cut-offs are: 0-12 No substantial depressive symptoms, 13-19 mild depressive symptoms, 20-34 moderate depressive symptoms, 35-54 severe depressive symptoms.

  Before the treatment, during week 1 to 10 of the treatment, after 11 weeks. Follow-up one year after the start of the treatment.

Secondary Outcomes (4)

• Change on Beck Depression Inventory-II (BDI-II)

  Before treatment and after 11 weeks, follow-up one year after the start of the treatment.

• Change on Brunnsviken Brief Quality of Life Inventory (BBQ)

  Before treatment and after 11 weeks, follow-up one year after the start of the treatment.

• Change on Generalized Anxiety Disorder 7-Item Scale (GAD-7)

  Before treatment and after 11 weeks, follow-up one year after the start of the treatment.

• Change on Reflective Functioning Questionnaire-8 item version (RFQ-8)

  Before treatment, after 11 weeks, following one year after the start of the treatment.

Other Outcomes (3)

• Change on The Medical Outcome Social Support Survey, 12-item short form (MOS-SSS)

  Before the treatment, during week 1 to 10 of the treatment, after 11 weeks.

• Score on Interpersonal Psychotherapy Outcome Scale (IPOS)

  Measured 11 weeks after the start of the intervention.

• Score on Credibility and Expectancy Questionnaire (CEQ)

  Measured during week 3 of the intervention.

Study Arms (2)

Interpersonal psychotherapy (IPT)

EXPERIMENTAL

10 weeks of internet-administered interpersonal psychotherapy with therapist support.

Behavioral: Interpersonal psychotherapy

Wait-list control group

NO INTERVENTION

The participants in the control group will receive access to the treatment after the post-treatment assessment has been conducted.

Interventions

Interpersonal psychotherapy BEHAVIORAL

Internet-based interpersonal psychotherapy aimed at reducing symptoms of depression. The content of the intervention is divided into three parts: the assessment phase (the first four weeks), the focus phase (the following five weeks), and the end phase (the last week).

Interpersonal psychotherapy (IPT)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A diagnosis of Major depressive disorder (as indicated by the MINI 7.0 Neuropsychiatric interview) and/or depressive symptoms equal to or more severe than mild depression on the MADRS-S (equal to or above 13 points) and/or BDI (equal to or above 14 points).
• Age of at least 18 years old.
• Adequate ability to speak, write, and read Swedish.
• Internet access for the duration of the study.

You may not qualify if:

• Ongoing substance abuse.
• Suicidal plans.
• A diagnosed personality syndrome (as diagnosed before the study by a licensed psychiatric healthcare professional).
• Other ongoing psychological treatment.
• Other severe psychiatric comorbidity that requires specialized care (e.g. anorexia nervosa, psychosis).
• Recent changes in psychotropic medication or planned changes during the initial treatment period.

Sponsors & Collaborators

• Linkoeping University: lead

Study Sites (1)

Department of Behavioral Sciences and Learning, Linköping University

Linköping, Östergötland County, 58183, Sweden

Location

Related Publications (1)

• Kall A, Back M, Fahlroth O, Ekeflod E, Lundberg A, Viberg N, Andersson G. Internet-based therapist-supported interpersonal psychotherapy for depression: A randomized controlled trial. J Affect Disord. 2025 Jan 15;369:188-194. doi: 10.1016/j.jad.2024.09.171. Epub 2024 Sep 27.

  PMID: 39343313 DERIVED

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

Interpersonal Psychotherapy

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 8, 2021
• First Posted: January 25, 2021
• Study Start: January 22, 2021
• Primary Completion: February 15, 2022
• Study Completion: February 15, 2022
• Last Updated: December 11, 2023

Record last verified: 2023-12

Locations

SE (1)