Linköping University Relational and Interpersonal Psychotherapy Project

NCT00763594 | Terminated Phase 2

• 1 other identifier: M59-08
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The study investigates the relative efficacy of Interpersonal Psychotherapy and Brief Relational Therapy for Major Depressive Disorder. The primary hypothesis is that there will be no mean difference in efficacy between treatments, but that Brief Relational Therapy will be more efficacious for more self-critical patients and Interpersonal Psychotherapy will be more efficacious for less self-critical patients.

Conditions

Major Depressive Disorder

Keywords

Major Depression; Interpersonal Psychotherapy; Brief Relational Therapy; Outcome research

Outcome Measures

Primary Outcomes (1)

• Hamilton Depression Rating Scale, 17 item version

  The primary outcome is depression severity immediately after termination, controlling for depression severity immediately before treatment. Depression severity is measured using the 17 item version of the Hamilton Depression Rating Scale.

  Change from before treatment to after termination (16 weeks)

Secondary Outcomes (5)

• Patient Health Questionnaire - 9

  Change from before treatment to after termination (16 weeks)

• Inventory of Interpersonal Problems

  Change from before treatment to after termination (16 weeks)

• Quality of Life Inventory

  Change from before treatment to after termination (16 weeks)

• Depressive Experiences Questionnaire

  Change from before treatment to after termination (16 weeks)

• Outcome Questionnaire - 45

  Change from before treatment to after termination (16 weeks)

Study Arms (2)

IPT

ACTIVE COMPARATOR

Interpersonal Psychotherapy for Major Depressive Disorder

Behavioral: Brief Relational Therapy; Behavioral: Interpersonal Psychotherapy

BRT

EXPERIMENTAL

Brief Relational Therapy adapted for treatment of Major Depressive Disorder

Behavioral: Brief Relational Therapy

Interventions

Brief Relational Therapy BEHAVIORAL

16 weeks of psychodynamically informed and therapy alliance focussed psychotherapy adapted for treating Major Depressive Disorder.

Also known as: Relational psychotherapy, Psychodynamic therapy, PDT

BRT; IPT

Interpersonal Psychotherapy BEHAVIORAL

16 weeks of Interpersonal Psychotherapy for Major Depressive Disorder

IPT

Eligibility Criteria

• Age: 17 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Major Depressive Disorder (DSM-IV)
• Hamilton Depression Rating Scale (17-item version) score 20 or greater

You may not qualify if:

• Any psychotic disorder
• Substance abuse
• Organic brain disorder

Sponsors & Collaborators

• Linkoeping University: lead
• Swedish Council for Working Life and Social Research: collaborator

Study Sites (1)

Linköping University

Linköping, SE-581 83, Sweden

Location

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

1-phenyl-3,3-dimethyltriazene; Interpersonal Psychotherapy

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Fredrik Falkenström, MA

  Sörmland County Council, Linköping University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: September 30, 2008
• First Posted: October 1, 2008
• Study Start: September 1, 2008
• Primary Completion: May 1, 2016
• Study Completion: December 1, 2017
• Last Updated: September 8, 2021

Record last verified: 2021-08

Locations

SE (1)