Southampton Women's Survey

NCT04715945 | Active Not Recruiting

• 1 other identifier: 276/97
• Study Type: observational
• Target: 12,583
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Southampton Women's Survey was established to assess the influence of factors operating before conception and during pregnancy on the health and development of the offspring. 12,583 non-pregnant young women were recruited, and 3,158 were followed through pregnancy, with their offspring followed-up at 6 months and 1, 2, 3, 4, 6-7, 8-9 and 12-13 years. The 17-19 year follow-up has been piloted and is about to start.

Conditions

Child Development; Child Obesity; Child Behavior; Nutritional and Metabolic Diseases; Asthma in Children; Cardiovascular Risk Factor; Bone Loss

Outcome Measures

Primary Outcomes (1)

• Child health and development

  Child health and development from birth to 19 years, focussing on body composition, nutrition, asthma and cardiovascular health

  0 - 19 years

Study Arms (2)

Women

12,583 women recruited when non-pregnant

Children

3,158 liveborn singleton offspring of women recruited to the study

Eligibility Criteria

• Age: 20 Years - 34 Years
• Gender Eligibility Details: Non-pregnant women
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All non-pregnant women in the correct age group living in Southampton between 1998 and 2002 were eligible.

You may qualify if:

• Not pregnant, resident in Southampton UK.

You may not qualify if:

• GP requested no contact

Sponsors & Collaborators

• University of Southampton: lead

Related Publications (3)

• Inskip HM, Godfrey KM, Robinson SM, Law CM, Barker DJ, Cooper C; SWS Study Group. Cohort profile: The Southampton Women's Survey. Int J Epidemiol. 2006 Feb;35(1):42-8. doi: 10.1093/ije/dyi202. Epub 2005 Sep 29. No abstract available.

  PMID: 16195252 RESULT

• El-Heis S, Crozier SR, Loo EX, Tham EH, Harvey NC, Inskip HM; Southampton Women's Survey Study Group; Godfrey KM. Maternal Dietary Inflammatory Status and Serum Neopterin During Pregnancy: Influence on Infantile Atopic Eczema in the Offspring. Clin Transl Allergy. 2025 Jul;15(7):e70080. doi: 10.1002/clt2.70080.

  PMID: 40714954 DERIVED

• Simpson RF, Hesketh KR, Crozier SR, Baird J, Cooper C, Godfrey KM, Harvey NC, Westgate K, Inskip HM, van Sluijs EMF. The association between number and ages of children and the physical activity of mothers: Cross-sectional analyses from the Southampton Women's Survey. PLoS One. 2022 Nov 16;17(11):e0276964. doi: 10.1371/journal.pone.0276964. eCollection 2022.

  PMID: 36383511 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood, urine, mouth swaps, umbilical cord, cord blood, placental samples

MeSH Terms

Conditions

Pediatric Obesity; Child Behavior; Nutritional and Metabolic Diseases; Bone Diseases, Metabolic

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases

Study Officials

• Cyrus Cooper, FMedSci

  University of Southampton

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 14, 2021
• First Posted: January 20, 2021
• Study Start: April 6, 1998
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
• Time Frame: Most data are already available and will continue to be available we hope beyond completion of the study.
• Access Criteria: Application to SWS oversight group