Vitamin A and D Intake in Pregnancy, Infant Supplementation and Asthma Development

NCT03197233 | Completed

• 3 other identifiers: PDB532_journal 08/2602-29221097ZO1ES49019
• Study Type: observational
• Target: 61,676
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this study is to investigate if maternal intake of vitamins A and D from food and dietary supplements during pregnancy, and infant supplementation with these vitamins, are associated with development of asthma in the offspring.

Conditions

Asthma in Children

Outcome Measures

Primary Outcomes (1)

• Child asthma based on dispensed asthma medications

  Dispensations of antiasthmatics (Anatomical Therapeutic Chemical Classification/ATC codes R03AC, R03BA, R03AK, and R03DC) registered in the Norwegian Prescription Database

  A minimum of two dispensations around age 7 years

Interventions

Maternal vitamin A and D intake during pregnancy OTHER

Dietary exposures during pregnancy and infant supplement use were assessed from maternal questionnaire report

Also known as: Total vitamin A and D intake from food and supplements

Eligibility Criteria

• Age: 7 Years - 7 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The Norwegian Mother and Child Study is a population-based pregnancy cohort (births 1999-2009). Women were recruited nationwide (41% participation) around 18 weeks gestation. The current study included 61,676 eligible chidren born 2002-2007.

You may qualify if:

• Available maternal dietary intake data from pregnancy. Child turned 7 years by July 1st 2014.

You may not qualify if:

• No maternal baseline questionnaire. Maternal energy intake \<4,500 or \> 20,000 kJ. No dietary supplement data. No linkage to national birth registry, or non-live births, or multiple births. Child death, or emigration, or unknown vital status.

Sponsors & Collaborators

• Norwegian Institute of Public Health: lead
• National Institute of Environmental Health Sciences (NIEHS): collaborator

Related Publications (3)

• Magnus P, Birke C, Vejrup K, Haugan A, Alsaker E, Daltveit AK, Handal M, Haugen M, Hoiseth G, Knudsen GP, Paltiel L, Schreuder P, Tambs K, Vold L, Stoltenberg C. Cohort Profile Update: The Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol. 2016 Apr;45(2):382-8. doi: 10.1093/ije/dyw029. Epub 2016 Apr 10.

  PMID: 27063603 BACKGROUND

• Ronningen KS, Paltiel L, Meltzer HM, Nordhagen R, Lie KK, Hovengen R, Haugen M, Nystad W, Magnus P, Hoppin JA. The biobank of the Norwegian Mother and Child Cohort Study: a resource for the next 100 years. Eur J Epidemiol. 2006;21(8):619-25. doi: 10.1007/s10654-006-9041-x. Epub 2006 Sep 20.

  PMID: 17031521 BACKGROUND

• Parr CL, Magnus MC, Karlstad O, Holvik K, Lund-Blix NA, Haugen M, Page CM, Nafstad P, Ueland PM, London SJ, Haberg SE, Nystad W. Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort. Am J Clin Nutr. 2018 May 1;107(5):789-798. doi: 10.1093/ajcn/nqy016.

  PMID: 29722838 DERIVED

Study Officials

• Wenche Nystad, PhD

  Dept of Non-Communicable Diseases, Norwegian Institute of Public Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2017
• First Posted: June 23, 2017
• Study Start: January 1, 1999
• Primary Completion: June 30, 2015
• Study Completion: June 30, 2015
• Last Updated: June 26, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will share