Exercise Capacity, Cardiovascular Risk Factors and Disease-related Variables in Axial Spondyloarthritis

NCT04706650 | Completed

• 1 other identifier: muğla sıtkı koçman university
• Study Type: observational
• Target: 76
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators aimed to study the associations between exercise capacity and cardiovascular (CV) risk factors in axial spondyloarthritis (axSpA) patients and to determine possible relationships with disease-related variables. Thirty eight patients and 38 controls were recruited in our cross-sectional controlled study. Comprehensive systemic and musculoskeletal examinations were carried out in both of the groups. Cardiovascular risk profile data, ASDAS-CRP, 10-year CV event risk, physical activity levels (IPAQ) were recorded. A maximal treadmill exercise test by Bruce protocol was administered to all participants.

Conditions

Exercise Capacity; Axial Spondyloarthritis

Keywords

axial spondyloarthritis; exercise capacity; cardiovascular risk factors; nonradiographic axial spondyloarthritis; cardiorespiratory fitness

Outcome Measures

Primary Outcomes (1)

• Mean difference in exercise capacity of axSpA patients and controls

  maximal METs achieved by a maximal treadmill test by Bruce protocol

  may- october 2014

Secondary Outcomes (1)

• Mean difference in heart rate recovery of axSpA patients and controls

  may- october 2014

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Thirty eight patients fulfilling the ASAS axial SpA criteria were recruited from the department of Gazi University Physical Medicine and Rehabilitation Rheumatology. 38 control subjects were randomly recruited from local hospital staff with a similar range of sex and age to the patients.

You may qualify if:

• clinical diagnosis of axial SpA
• must be able to walk

You may not qualify if:

• established cardiac disease including structural heart diseases,
• uncontrolled hypertension,
• cardiac rhythm disorder,
• unstable angina pectoris,
• chronical renal and/or hepatic disease,
• malignancy,
• neuromuscular disease
• musculoskeletal deformity
• the history of an inflammatory arthritis for control group

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

MeSH Terms

Conditions

Axial Spondyloarthritis

Condition Hierarchy (Ancestors)

Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist medical doctor

Study Record Dates

• First Submitted: January 5, 2021
• First Posted: January 13, 2021
• Study Start: May 15, 2014
• Primary Completion: October 15, 2014
• Study Completion: October 15, 2014
• Last Updated: January 13, 2021

Record last verified: 2021-01