Brief Summary

The goal of this study is to develop evidence-based messages that effectively mitigate concerns of people at risk for not being vaccinated against COVID-19, with the ultimate goal of maximizing vaccine uptake in vulnerable populations. The investigators will collect data on COVID-19 disease and vaccine knowledge, beliefs, and intent to be vaccinated from an existing online panel. Results from this data collection will be used to develop effective messages and communication strategies. The investigators will test alternate versions of messages intended to reduce vaccine hesitancy and promote vaccine uptake among vaccine-hesitant individuals. This project will ultimately result in a set of tested, evidence-derived messages about vaccination for COVID-19.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

756

participants targeted

Target at P75+ for not_applicable covid19

Timeline

Completed

Started Jan 2021

Shorter than P25 for not_applicable covid19

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

20 days study duration

First Submitted

Initial submission to the registry

January 5, 2021

Completed

7 days until next milestone

First Posted

Study publicly available on registry

January 12, 2021

Completed

Same day until next milestone

Study Start

First participant enrolled

January 12, 2021

Completed

20 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2021

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2021

Completed

11 months until next milestone

Results Posted

Study results publicly available

January 5, 2022

Completed

Last Updated

May 24, 2022

Status Verified

May 1, 2022

Enrollment Period

20 days

First QC Date

January 5, 2021

Results QC Date

December 20, 2021

Last Update Submit

May 20, 2022

Conditions

Covid19

Keywords

Covid-19Vaccination

Outcome Measures

Primary Outcomes (1)

Number of Participants Who Became Less Hesitant About the COVID-19 Vaccine After Receiving a Physician Message
All participants were asked about their intent to be vaccinated against COVID-19 prior to exposure to one of the five physician messages (Response options: Yes, No, Not sure). After participants were randomly assigned to receive one of the five physician messages, reduction in COVID-19 vaccine hesitancy was assessed with the question: "Would you get vaccinated at this visit". Response options included yes, no, not sure. For participants whose initial vaccination intent was "not sure", a response of "yes" on re-assessment was defined as less hesitant. Response of "not sure" or "yes" were defined as less hesitant for participants whose initial vaccination intent was "no".
Through survey completion, an average of 12 minutes

Study Arms (5)

Message 1

EXPERIMENTAL

Participants were randomized to receive version #1 of 5 different versions of a message from a physician regarding the COVID-19 vaccination. All messages included a statement that the vaccine is very safe and very effective. In Message 1, this statement was followed by a participatory-style recommendation ("What do you think?")