Transcranial Magnetic Stimulation in the Rehabilitation of Postoperative Motor Dysfunction.

NCT04706338 | Unknown DMC

• 1 other identifier: KY-2020-128-01
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study focused on glioma patients with postoperative motor deficits, especially for patients with supplementary motor area syndrome. The investigators want to investigate whether the recovery of motor function will be accelerated by using transcranial magnetic stimulation to stimulate primary motor area and supplementary motor area on the lesional hemisphere.

Conditions

Glioma; Postoperative Motor Deficit

Outcome Measures

Primary Outcomes (1)

• Accelerate motor functional recovery

  The ratio of motor functional recovery in patients with TMS treatment is higher than those do not receive TMS treatment and the time of motor funcitonal recovery is shorter than those do not receive.

  From the day of tumor resection to 3 months after tumor resection.

Study Arms (1)

TMS treatment

EXPERIMENTAL

Patients with TMS treatment

Device: TMS treatment

Interventions

TMS treatment DEVICE

Using TMS to stimulate (5 Hz, 90%\~110% resting motor threshold) patients' primary motor area and SMA.

TMS treatment

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patient underwent awake craniotomy and motor functional identification during tumor resection;
• patients with postoperative motor deficit (muscle strength of limbs is weaker than preoperative status)

You may not qualify if:

• patients with contraindication of transcranial magnetic stimulation;
• patients without data of the pre- and postoperative resting state MRI and diffusion tensor image.

Sponsors & Collaborators

• Beijing Neurosurgical Institute: lead

Study Sites (1)

Beijing Neurosurgical Institute and Beijing Tiantan Hospital

Beijing, Beijing Municipality, 100005, China

RECRUITING

Related Publications (2)

• Dionisio A, Duarte IC, Patricio M, Castelo-Branco M. The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review. J Stroke Cerebrovasc Dis. 2018 Jan;27(1):1-31. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.008. Epub 2017 Oct 27.

  PMID: 29111342 BACKGROUND

• Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipovic SR, Grefkes C, Hasan A, Hummel FC, Jaaskelainen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorova I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018). Clin Neurophysiol. 2020 Feb;131(2):474-528. doi: 10.1016/j.clinph.2019.11.002. Epub 2020 Jan 1.

  PMID: 31901449 BACKGROUND

MeSH Terms

Conditions

Glioma

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Jiang Tao

  Beijing Neurosurgical Institute

  STUDY CHAIR

Central Study Contacts

Shengyu Fang, MD

CONTACT

+8613466331405; fangtuo1@aliyun.com

Yinyan Wang, MD

CONTACT

+8613581688953; tiantanyinyan@126.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: patients with postoperative motor deficits, especially for patients with SMA syndrome.

Study Record Dates

• First Submitted: January 10, 2021
• First Posted: January 12, 2021
• Study Start: January 15, 2021
• Primary Completion: June 1, 2021
• Study Completion: January 1, 2022
• Last Updated: January 14, 2021

Record last verified: 2021-01

Locations

CN (1)