Application of Cognitive Training Based on the Remind Strategy in Glioma Patients With Cognitive Impairment

NCT06327048 | Completed

• 1 other identifier: LZUHLXY20230110
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to form an interdisciplinary team to dynamically evaluate patient cognitive outcomes and develop an individualized cognitive training program for Chinese brain tumor patients

Conditions

Glioma

Keywords

cognitive training; cognitive impairment; Quality of Life

Outcome Measures

Primary Outcomes (1)

• Montreal Cognitive Assessment(MoCA)

  The Montreal Cognitive Assessment (MoCA) is commonly used to assess cognitive function, typically taking about 15 minutes to complete. It has a total score of 30 points, with a score of ≥26 considered normal. Lower scores indicate more severe cognitive impairment. MoCA is advantageous due to its ease of administration, short duration, and high reliability and validity.

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

Secondary Outcomes (5)

• The European Organization for Research and Treatment of Cancer core Quality of Life Questionnaire (EORTC QLQ-C30)

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

• The EORTC QLQ-Brain Neoplasms 20(EORTC QLQ-BN20)

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

• Self-Rating Anxiety Scale(SAS)

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

• Self-Rating Depression Scale(SDS)

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

• Modified Barthel Index(MBI)

  The day after admission, 7 days after surgery (baseline), at 4-week and 12-week of intervention.

Study Arms (2)

Control group

NO INTERVENTION

Routine rehabilitation nursing

Intervention group

EXPERIMENTAL

On the basis of routine rehabilitation nursing, individual cognitive rehabilitation training based on Remind strategy was given

Other: Individual cognitive rehabilitation training based on Remind strategy was given

Interventions

Individual cognitive rehabilitation training based on Remind strategy was given OTHER

This training educates and learns patients from the aspects of assessment of cognitive function and strategic compensation for the impact of cognitive impairment on patients, and then conducts attention, memory and executive function training and attention retraining based on patients' cognitive function to improve patients' cognitive function

Intervention group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Conforming to the diagnostic criteria outlined in the "Chinese Clinical Guidelines for Diagnosis and Treatment of Central Nervous System Gliomas (2015)" ;
• Patients diagnosed with brain gliomas through histopathological and/or cytological examination;
• MoCA (Montreal Cognitive Assessment) score ≤ 26;
• Karnofsky Performance Status (KPS) score ≥ 60, with no history of past illnesses;
• Age ≥ 18 years;
• Clear consciousness;
• Willingness to participate and signed informed consent form.

You may not qualify if:

• Diagnosed with neurological or psychiatric disorders within the past two years;
• Impaired consciousness;
• Accompanied by severe complications such as infections;
• Nursing Delirium Screening Checklist (Nu-DESC) score ≥ 2;
• Patients with changes in condition or requiring repeat surgery;
• Patients with multiple intracranial tumors;
• Inability to effectively complete the questionnaire or withdrawal during the study.

Sponsors & Collaborators

• YuanYuan Ma: lead

Study Sites (1)

Yuanyuanma

Lanzhou, Gansu, China

Location

MeSH Terms

Conditions

Glioma; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• peifen ma, Master

  Lanzhou University Second Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Blind the evaluator
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: supervisor nurse

Model Details: Non-randomized intervention study

Study Record Dates

• First Submitted: February 29, 2024
• First Posted: March 25, 2024
• Study Start: January 21, 2024
• Primary Completion: January 12, 2025
• Study Completion: January 12, 2025
• Last Updated: August 12, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)