Antibacterial and Anti-biofilm Activity of Frankincense Extract Against Porphyromonas Gingivalis
Antibacterial Activity of Boswellia Sacra Flueck. Oleoresin Extract Against Porphyromonas Gingivalis Periodontal Pathogen.
1 other identifier
interventional
30
1 country
1
Brief Summary
Boswellia sacra Flueck. oleoresin extract (frankincense) was traditionally used in the treatment of different diseases as respiratory, rheumatoid arthritis, and bacterial infections. Therefore, the antibacterial and antibiofilm activity of frankincense extract against Porphyromonas gingivalis periodontal pathogen clinical isolates were studied
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Jan 2021
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 3, 2021
CompletedFirst Posted
Study publicly available on registry
January 12, 2021
CompletedStudy Start
First participant enrolled
January 15, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2021
CompletedJuly 22, 2021
July 1, 2021
2 months
January 3, 2021
July 16, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
isolation of the p. gingivalis
Isolated bacteria will be cultured on specific media and Antimicrobial activity of the extract will be examined by disc diffusion method
at day zero for in vitro study
Secondary Outcomes (1)
GC-MS analysis
"up to 24 weeks"
Other Outcomes (3)
Crystal violet assay
baseline
Light microscope and scanning electron microscope
"up to 24 weeks"
qRT-PCR
"up to 24 weeks"
Study Arms (1)
Frankincense Extract
EXPERIMENTALthe anti-bacterial and antibiofilm activity of frankincense extract against Porphyromonas gingivalis clinical isolates were studied
Interventions
The phytochemical composition of the volatile components of the extract was identified by GC-MS analysis, Crystal violet assay to test inhibition of biofilm formation by the tested isolates,Light microscope and scanning electron microscope were used to examine the biofilms and they confirmed the reduction of biofilm formation by frankincense extract
Eligibility Criteria
You may qualify if:
- patients with grade III stage b periodontitis , patients who have the willing to participate in the study and informed consents will be taken from them
You may not qualify if:
- patients who are under antibiotic therapy or any antimicrobial drugs
- smokers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tanta Universitylead
Study Sites (1)
Malak Mohamed Shoukheba
Tanta, 020, Egypt
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
malak m shoukheba, PHD
faculty of dentistry tanta university
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- associate prof.
Study Record Dates
First Submitted
January 3, 2021
First Posted
January 12, 2021
Study Start
January 15, 2021
Primary Completion
March 1, 2021
Study Completion
March 1, 2021
Last Updated
July 22, 2021
Record last verified: 2021-07