Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients
1 other identifier
interventional
15
1 country
1
Brief Summary
Osteocalcin levels can be measured Gingival crevicular fluid (GCF). Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. The levels of this markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue in periodontal affected teeth.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 14, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 20, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
August 23, 2023
CompletedFirst Submitted
Initial submission to the registry
October 22, 2023
CompletedFirst Posted
Study publicly available on registry
October 26, 2023
CompletedNovember 28, 2023
November 1, 2023
1.2 years
October 22, 2023
November 26, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Osteocalcin levels in gingival crevicular fluid before and during orthodontic tooth movement
ELISA test to measure osteocalcin in GCF
at baseline, then after 3 months and after 6 month
Study Arms (1)
periodontal compromised orthodontic pateints
EXPERIMENTALperiodontal compromised adults female patients with sever dental crowding and seeking for orthodontic treatment
Interventions
in gingival crevicular fluid before and during orthodontic tooth movement
Eligibility Criteria
You may qualify if:
- Adult female patients who were seeking for orthodontic treatment with controlled previous chronic periodontitis.
- Pocket depth of more than 5 mm before receiving non-surgical periodontal treatment or/and Pocket depth of less than 4 mm after periodontal therapy.
- Sever to very sever irregularity of mandibular anterior arch according to Little's irregularity index ranging from 7 to 10 mm with acceptable oral hygiene.
- all the permanent dentition excluding third molars should be present.
- No systemic disease or history of prolonged use of medication interfering with tooth movement as corticosteroids.
You may not qualify if:
- Previous orthodontic treatment.
- Patients with aggressive periodontitis or Any smoking habits.
- Pregnant or lactating female patients were excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
faculty of dental medicine Azhar University
Cairo, 1871, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer of Orthodontics
Study Record Dates
First Submitted
October 22, 2023
First Posted
October 26, 2023
Study Start
January 14, 2022
Primary Completion
March 20, 2023
Study Completion
August 23, 2023
Last Updated
November 28, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share