Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, Liberia

NCT04704674 | Active Not Recruiting

• 2 other identifiers: 10000158000158-I
• Study Type: observational
• Target: 396
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Malaria is a disease that affects many people in Liberia. It is caused by germs (parasites) that are spread by mosquito bites. Researchers want to gather data that may help them understand the best way to use a malaria vaccine in Liberia, which will be important in getting rid of the disease. Objective: To find out how often people of all ages who live in Fleh-la and Marshansue, Liberia, get malaria. Eligibility: Healthy people ages 6 months and older who live in Fleh-la and Marshansue in a household with adults and children. Design: Participants will be screened with a physical exam and questions about their health. Participants will have monthly study visits. They will be asked about any symptoms of malaria and their use of bednets. Their vital signs, such as blood pressure and temperature, will be checked. Blood will be taken from the participant s arm or finger with a needle. If they have a fever, they will get a malaria test. If positive, they will get drugs to treat malaria. Once a month, participants houses will be examined for mosquitoes. The team will remove all mosquitoes they collect. As part of this collection, participants houses will be sprayed with a chemical to kill mosquitoes and other insects. Participants will not be allowed in their house while the team is inside. The spray will not harm the participants. Once a year, at the monthly visit, an additional blood sample will be taken. Some of the participants blood samples will be used for genetic testing. Participation will last for up to 3 years.

Conditions

Malaria

Keywords

Assays; BLOOD SAMPLING; Parasites; Gametocyte; Infection; Natural History

Outcome Measures

Primary Outcomes (1)

• Measurement of Monthly rates of blood smear positive individuals by age

  Rate of blood smear positive individuals

  one year

Study Arms (4)

0.5 - 5 years

Age bracket for infants/children up to age five years

10 - 18 years

Age bracket for children 10 - 18 years

19 + years

Age bracket for adults over 19 years

5 - 10 years

Age bracket for children ages 5 - 10 years

Eligibility Criteria

• Age: 6 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

An estimated total of 400 volunteers from Fleh-la and Marshansue and surrounding villages will be enrolled. Participants above the age of six months will be approached to participate in the study; and will be followed for up to 3 years.

You may qualify if:

• months of age and above
• Known resident of Fleh-la and Marshansue or the surrounding villages and planning to remain for duration of study
• Willingness to allow stored laboratory specimens to be used for future research
• Acceptance and signature of the written informed consent and the assent for children aged 12-17 years who are not otherwise emancipated
• To be eligible for participation, households must meet the following criteria:
• Household with at least 3 residents eligible for participation.
• Household with at least one compound member who is below 18 years of age whose parents or caretakers are willing to provide informed consent for the child to participate.
• Household members willing to accommodate mosquito sampling in their compound, both indoors and outdoors.

You may not qualify if:

• Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol.
• Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

National Public Health Institute of Liberia (NPHIL)

Fleh-la, Liberia

Location

MeSH Terms

Conditions

Malaria; Infections

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Mosquito-Borne Diseases; Vector Borne Diseases

Study Officials

• Jennifer C Hume

  National Institute of Allergy and Infectious Diseases (NIAID)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2021
• First Posted: January 12, 2021
• Study Start: September 30, 2021
• Primary Completion: April 28, 2023
• Study Completion: February 28, 2026
• Last Updated: January 16, 2026

Record last verified: 2026-01-06

Data Sharing

• IPD Sharing: Will not share

Locations

LI (1)