NCT04703348

Brief Summary

Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery capacities. Nowadays, the use of motor imagery exercises are used in conventional rehabilitation treatments. But, in clinical practice, no study has verified if patients with CRPS desmonstrate problems in their motor imagery capacities. The MIQ-RS (Motor Imagery Questionnaire - Revised Second) is a valid, reliable and translated into French questionnaire to measure patients' capacities to do mental imagery. In this study, we compare 3 groups of 50 patients : healthy patients, patients with CRPS and patients with musculoskeletal disorder without CRPS. Every patient will take the MIQ-RS for the right and left body side. We hypothesis that patients with CRPS have more deficit than the 2 others to realise motor imagery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
129

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2021

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 7, 2021

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 11, 2021

Completed
1 day until next milestone

Study Start

First participant enrolled

January 12, 2021

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2022

Completed
Last Updated

December 4, 2025

Status Verified

November 1, 2022

Enrollment Period

1.8 years

First QC Date

January 7, 2021

Last Update Submit

November 27, 2025

Conditions

Keywords

complex regional pain syndromesmotor imagerymental imageryMIQ-RSPilot studycomparison groupsCRPS

Outcome Measures

Primary Outcomes (1)

  • Motor imagery capacities on the affected side for CRPS group and musculoskelettal disorder group.

    Taking the MIQ-RS for 1 side, during about 20 minutes The questionnaire includes 14 questions : 7 for kinesthesic motor imagery and 7 for visual motor imagery For less bias, the questionnaire was recorded in audio for each of the 14 questions on an online assessment. No official cut-off exists but studies seem to prove that people with : * a score less than 48/98 are unable to do motor imagery * a score between 49 and 73/98 have disturbed motor imagery capacities * a score more than 74/98 have normal motor imagery capacities.

    Day 1

Secondary Outcomes (1)

  • Motor imagery capacities between affected side and unaffected side

    Day 1

Study Arms (3)

Healthy patients

OTHER

Healthy patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)

Complex regional pain syndrome patients

OTHER

Complex regional pain syndrome patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)

Musculoskelettal disorders patients

OTHER

Musculoskelettal disorders patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Diagnostic Test: Motor imagery Questionnaire - Revised Second (MIQ-RS)

Interventions

Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with : * a score less than 48/98 are unable to do motor imagery * a score between 49 and 73/98 have disturbed motor imagery capacities * a score more than 74/98 have normal motor imagery capacities.

Complex regional pain syndrome patientsHealthy patientsMusculoskelettal disorders patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient with French healthcare affiliation
  • Adult patient (\> 18 years old)
  • Patient with bachelor degree minimum
  • Patient practicing less than 150 minutes of moderate to intense physical activity per week
  • Patient followed in the Evaluation and Treatment pain center (University Hospital of Nimes)
  • Patient with secondary CRPS due to a traumatism or a surgery
  • Patient with musculoskelettal disorder on a limb (upper or lower)
  • Patient followed in the University Hospital of Nimes
  • Patient who participates in another category 1 research
  • Patient under legal protection, under guardianship or under curatorship
  • Patient for whom it is impossible to give clear information.
  • Pregnant, parturient or breastfeeding patient.
  • Patient with amputation on one of his limb
  • Patient with visual cecity
  • Patient who has already practiced mental imagery
  • +5 more criteria

You may not qualify if:

  • Questionnaire MIQ-RS not completed or non respect with the research protocol
  • pathology discovered incompatible with the study criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Nimes

Nîmes, Gard, 30029 NIMES Cedex 9, France

Location

Related Publications (1)

  • Cohen-Aknine G, Mottet D, Homs AF, Mura T, Jedryka F, Dupeyron AF. Explicit Motor Imaging Abilities Are Similar in Complex Regional Pain Syndrome, Chronic Limb Pain and Healthy Individuals: A Cross-Sectional Study. J Pain Res. 2025 Apr 11;18:1949-1961. doi: 10.2147/JPR.S494546. eCollection 2025.

Related Links

MeSH Terms

Conditions

Complex Regional Pain SyndromesCollagen Diseases

Condition Hierarchy (Ancestors)

Autonomic Nervous System DiseasesNervous System DiseasesPeripheral Nervous System DiseasesNeuromuscular DiseasesConnective Tissue DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Model Details: 3 groups with different healthcare conditions are compared in motor imagery capacities
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 7, 2021

First Posted

January 11, 2021

Study Start

January 12, 2021

Primary Completion

October 30, 2022

Study Completion

October 30, 2022

Last Updated

December 4, 2025

Record last verified: 2022-11

Locations