Cybersickness imAgiNg Olfactory Evocation
CANOE
1 other identifier
interventional
30
1 country
1
Brief Summary
The aim of this study is to, using fMRI, compare brain activations during olfactory imagery induced by different visual supports (words, pictures, colors and colored arrangements) in healthy subjects. This will allow us to choose the best olfactory imagery facilitator and to assess its effect on cybersickness.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Apr 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 4, 2022
CompletedFirst Posted
Study publicly available on registry
April 4, 2022
CompletedStudy Start
First participant enrolled
April 13, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 12, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
October 26, 2022
CompletedNovember 7, 2022
November 1, 2022
3 months
March 4, 2022
November 4, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Comparison of cerebral activations between the different supports mediating the olfactory imagination during the execution of the fMRI tasks.
The cerebral activations between the different supports mediating the olfactory imagination will be compared in terms of localization and intensity of the variations of the BOLD signal during the execution of the fMRI tasks.
Baseline (J0)
Secondary Outcomes (6)
Determination of the visual support allowing the strongest olfactory imagination during the fMRI by subjective evaluations using two 4-level Likert scales.
Baseline (J0)
Determination of the visual support allowing the strongest olfactory imagination during the fMRI test by the cerebral activations in areas recognized for their implications in the olfactory imagination.
Baseline (J0)
Description of the evolution of the cardiac activity during olfactory imagination tasks in fMRI.
Baseline (J0)
Description of the evolution of the respiratory activity during olfactory imagination tasks in fMRI.
Baseline (J0)
Evaluation of the state of discomfort in virtual reality by measuring the cardiac activity.
Baseline (J0) and 6 months maximum after J0 (V1)
- +1 more secondary outcomes
Study Arms (1)
Experimental
EXPERIMENTALInterventions
The volunteer will have to imagine the smells evoked by different visual aids. This task will be carried out during 2 acquisition runs of about 10 minutes each. The volunteer should note (on a scale from 1 to 4) the pleasantness of the smell evoked.
The volunteer will be immersed in a virtual maritime environment with nauseating characteristics. In the center of the maritime scene, it will be visible the black outlines of a frame. Every minute, the volunteer will be asked to verbalize the level of his general condition via the Fast Motion Sickness Scale (1 to 20).
The volunteer will be immersed in a virtual maritime environment with nauseating characteristics. The visual support inserted in the center of the virtual scene will be the one defined as being the most facilitator of the olfactory imagination during the fMRI examination. The volunteer will be asked to concentrate on the smell evoked by this support. Every minute, the volunteer will be asked to verbalize the level of his general condition via the Fast Motion Sickness Scale (1 to 20).
Eligibility Criteria
You may qualify if:
- to be of French nationality who has always lived in metropolitan France;
- to be right-handed person;
- to be enrolled in a social security plan;
- to be able to understand the instructions given;
- to give a written consent;
- Person with a strong capacity for olfactory imagination: having obtained a score strictly below 2.5 on the fVOIQ olfactory imagination questionnaire.
You may not qualify if:
- to have an inability to read French;
- to be recognized as a synesthete;
- to have a professional activity requires intense olfactory activity;
- to have a partial or total loss of smell (hyposmia, anosmia);
- to have qualitative smell disorders (carcosomia, hyperosmia, phantosmia, parosmia);
- to have smell disorders of neurological, post-traumatic or neurodegenerative origin;
- to have uncorrected or poorly corrected visual disturbances;
- to have vestibular disorder diagnosed;
- any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … );
- subject under a measure of legal protection.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHRU Nancy
Nancy, France
Related Publications (1)
Fantin L, Ceyte H, Ramdane-Cherif Z, Jacquot M, Hossu G. French Vividness of Olfactory Imagery Questionnaire: A Potential Tool for Diagnosing Olfactory Loss by Assessing Olfactory Imagery? Front Psychol. 2020 Dec 21;11:606667. doi: 10.3389/fpsyg.2020.606667. eCollection 2020.
PMID: 33408672BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 4, 2022
First Posted
April 4, 2022
Study Start
April 13, 2022
Primary Completion
July 12, 2022
Study Completion
October 26, 2022
Last Updated
November 7, 2022
Record last verified: 2022-11