Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis

NCT04689906 | Completed

• 1 other identifier: HTVSPTAPP1
• Study Type: observational
• Target: 3,137
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis. Current literature supports time from symptom onset until registration as the main and maybe only determinant of the outcome if patients are operated on within 24 hours. We wish to evaluate whether this is true in all patients, or there are subgroups in which time from registration to operation is associated with complicated appendicitis.

Conditions

Acute Appendicitis

Keywords

Appendicitis; Ruptured Appendicitis; Appendectomy; Timing of Surgery

Outcome Measures

Primary Outcomes (1)

• proportion of complicated appendicitis

  complicated appendicitis defined as either gangrenous appendicitis, perforation with abscess, perforation with local peritonitis, perforation with diffuse peritonitis

  finding during surgery/pathology

Interventions

surgery OTHER

This is a retrospective study that includes patients operated for suspicion of acute appendicitis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients operated in one medical center during one decade.

You may qualify if:

• male and female patients of all ages who underwent appendectomy of acute appendicitis in a single medical center between December 1, 2006, and December 31, 2016

You may not qualify if:

• interval appendectomy,
• incidental appendectomy,
• appendectomy after failed antibiotic treatment for either acute appendicitis or peri-appendicular abscess
• patients with a non-inflamed appendix
• those in whom symptom onset before hospitalization was not noted.

Sponsors & Collaborators

• Rambam Health Care Campus: lead
• Hillel Yaffe Medical Center: collaborator

Related Publications (2)

• Ashkenazi I, Zeina AR, Olsha O. Early ultrasound in acute appendicitis avoids CT in most patients but delays surgery and increases complicated appendicitis if nondiagnostic - A retrospective study. Am J Surg. 2020 Apr;219(4):683-689. doi: 10.1016/j.amjsurg.2019.05.013. Epub 2019 May 25.

  PMID: 31153584 BACKGROUND

• Ashkenazi I, Zeina AR, Olsha O. In-hospital delay of surgery increases the rate of complicated appendicitis in patients presenting with short duration of symptoms: a retrospective cohort study. Eur J Trauma Emerg Surg. 2022 Oct;48(5):3879-3886. doi: 10.1007/s00068-022-01912-3. Epub 2022 Feb 24.

  PMID: 35211772 DERIVED

MeSH Terms

Conditions

Appendicitis

Interventions

Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Officials

• Itamar Ashkenazi, MD

  Rambam Health Care Campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Staff Physician

Study Record Dates

• First Submitted: December 28, 2020
• First Posted: December 30, 2020
• Study Start: December 1, 2006
• Primary Completion: December 31, 2016
• Study Completion: August 1, 2017
• Last Updated: January 5, 2021

Record last verified: 2020-12