NCT05116124

Brief Summary

Acute appendicitis is a major cause of acute abdomen. Although its diagnosis is clinical, it is often supported by complementary diagnostic tests. Sometimes, delay in diagnosis can lead to worsening of the clinical picture, resulting in a complicated acute appendicitis. Some series have studied some clinical and analytical parameters as possible predictors of complicated acute appendicitis. A retrospective analysis of patients admitted for acute appendicitis and undergoing appendectomy between January 2014 and December 2017 was performed in order to assess the possible existence of preoperative analytical predictive factors for complicated acute appendicitis (such as leukocytosis, C-reactive protein and ratio between neutrophils and lymphocytes).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
841

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2014

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2014

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2017

Completed
3.8 years until next milestone

First Submitted

Initial submission to the registry

October 19, 2021

Completed
22 days until next milestone

First Posted

Study publicly available on registry

November 10, 2021

Completed
Last Updated

November 10, 2021

Status Verified

November 1, 2021

Enrollment Period

4 years

First QC Date

October 19, 2021

Last Update Submit

November 1, 2021

Conditions

Acute Appendicitis

Outcome Measures

Primary Outcomes (3)

  • C-reactive protein dosage

    4 years

  • Leukocytosis dosage

    4 years

  • Ratio between neutrophils and lymphocytes dosage

    4 years

Study Arms (2)

Group 1 - uncomplicated appendicitis

Other: dosing of inflammatory parameters

Group 2 - complicated appendicitis

Other: dosing of inflammatory parameters

Interventions

dosing of inflammatory parametersOTHER

View and register the dosing of inflammatory parameters

Group 1 - uncomplicated appendicitisGroup 2 - complicated appendicitis

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients admitted for acute appendicitis

You may qualify if:

  • all patients admitted for acute appendicitis

You may not qualify if:

  • excluded if no existence of dosing of all the inflammatory parameters cited above

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal InfectionsInfectionsGastroenteritisGastrointestinal DiseasesDigestive System DiseasesCecal DiseasesIntestinal Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

October 19, 2021

First Posted

November 10, 2021

Study Start

January 1, 2014

Primary Completion

December 31, 2017

Study Completion

December 31, 2017

Last Updated

November 10, 2021

Record last verified: 2021-11