Adolescent Idiopathic Scoliosis and Proprioceptive Defect

NCT04682379 | Unknown

• 1 other identifier: UW 20-525
• Study Type: observational
• Target: 166
• Locations: 1 country
• Sites: 1

Brief Summary

This is the first clinical study to examine the spinal and peripheral proprioceptive deficits in longitudinal terms among subjects with adolescent idiopathic scoliosis.

Conditions

Adolescent Idiopathic Scoliosis; Idiopathic Scoliosis; Scoliosis

Outcome Measures

Primary Outcomes (2)

• Repositioning errors

  The deviation between the position achieved by the subject and the reference position.

  Baseline

• Repositioning errors

  The deviation between the position achieved by the subject and the reference position.

  One year follow-up

Study Arms (2)

Scoliotic patients with proprioceptive deficits

Study subjects possessed statistically significant differences in testing outcomes of proprioception compared with healthy controls.

Diagnostic Test: Proprioceptive assessment

Scoliotic patients without proprioceptive deficits

Study subjects with similar testing results of proprioception compared with healthy controls.

Diagnostic Test: Proprioceptive assessment

Interventions

Proprioceptive assessment DIAGNOSTIC_TEST

1. Trunk flexion-extension repositioning test 2. Trunk lateral-flexion repositioning test 3. Trunk axial-rotation repositioning test 4. Neck rotation repositioning test 5. Elbow flexion repositioning test 6. Knee extension repositioning test

Scoliotic patients with proprioceptive deficits; Scoliotic patients without proprioceptive deficits

Eligibility Criteria

• Age: 10 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Potential participants will be identified by consecutively screening in the clinics of the speciality outpatient department at the Hospital for all patients with scoliosis

You may qualify if:

• diagnosis of adolescent idiopathic scoliosis
• did not receive or failed conservative treatment

You may not qualify if:

• spinal injury, fracture, or spinal tumour
• neurological deficit
• brain or spinal cord abnormality
• developmental delay
• psychological disorder

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

The Duchess of Kent Children's Hospital

Hong Kong, Hong Kong

Location

Related Publications (3)

• Lau KKL, Law KKP, Kwan KYH, Cheung JPY, Cheung KMC, Wong AYL. Timely Revisit of Proprioceptive Deficits in Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis. Global Spine J. 2022 Oct;12(8):1852-1861. doi: 10.1177/21925682211066824. Epub 2021 Dec 15.

  PMID: 34911378 BACKGROUND

• Lau KKL, Law KKP, Kwan KYH, Cheung JPY, Cheung KMC. Proprioception-related gene mutations in relation to the aetiopathogenesis of idiopathic scoliosis: A scoping review. J Orthop Res. 2023 Dec;41(12):2694-2702. doi: 10.1002/jor.25626. Epub 2023 Jun 4.

  PMID: 37203456 BACKGROUND

• Lau KK, Kwan KY, Cheung JP, Chow W, Law KK, Wong AY, Chow DH, Cheung KM. Reliability of a three-dimensional spinal proprioception assessment for patients with adolescent idiopathic scoliosis. Eur Spine J. 2022 Nov;31(11):3013-3019. doi: 10.1007/s00586-022-07338-0. Epub 2022 Aug 3.

  PMID: 35922635 BACKGROUND

MeSH Terms

Conditions

Scoliosis

Condition Hierarchy (Ancestors)

Spinal Curvatures; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases

Study Officials

• Kenneth Cheung

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2020
• First Posted: December 23, 2020
• Study Start: January 11, 2021
• Primary Completion: August 1, 2024
• Study Completion: December 1, 2024
• Last Updated: April 1, 2024

Record last verified: 2024-01

Locations

HK (1)