Diabetes Diagnosis During Acute Admissions (FIND-IT)

NCT04653545 | Completed

• 1 other identifier: Tameside002
• Study Type: observational
• Target: 5,050
• Locations: 1 country
• Sites: 1

Brief Summary

People with type 2 diabetes are two-and-a-half times more likely to experience heart failure and twice more likely to have a heart attack compared to people without diabetes. People coming to hospital often have unknown hyperglycaemia. It is thought that three quarters of people admitted to the Coronary care unit with a myocardial infarction have hyperglycaemia and over a third of whom are undiagnosed with diabetes and over 40% with impaired glucose tolerance (IGT). All of these patients are at greater risk of poor outcomes in the presence of uncontrolled hyperglycaemia. Patients presenting to A\&E have routine bloods taken for condition which are they are being investigated and treated for. Therefore the aim of the study is to identify the prevalence of undiagnosed diabetes (HbA1c \>48mmol/mol) or impaired glucose tolerance/pre-diabetes (HbA1c \>39mmol/mol) in patients attending the accident and emergency department or acute medical unit and to see if this is a good screening measure for diagnosis of diabetes. This project will help identify those undiagnosed with glucose intolerance (T2D and IGT) and instigate appropriate treatment and improve outcomes for this group of patients. This will in the long term reduce the burden to the NHS. This project will help in the development of guidance for diagnosis of T2D in an acute setting and treatment for hospital admission and continued care. This project will include 10,000 consecutive patients over the age of 30 years attending the A\&E or AMU departments of Tameside and Glossop Integrated Care NHS FT. All patients will be screened for glucose intolerance with a blood test in which patients' blood would be taken anyway for clinical reasons and the laboratory will perform an HbA1c investigation on the sample collected.

Conditions

Diabete Type 2

Outcome Measures

Primary Outcomes (1)

• What is the prevalence of glucose intolerance (diabetes and IGT) in patients presenting to an acute medical emergency department?

  How many patients not known to have diabetes, are diagnosed with the condition

  52 weeks

Secondary Outcomes (3)

• Diabetes complications, if any, are present

  52 weeks

• Cardiovascular complications

  52 weeks

• Diabetes control in those with known diabetes

  52 weeks

Interventions

HbA1c DIAGNOSTIC_TEST

Blood will be taken as per requirement for patients being admitted to hospital. A small sample will be sent to the biochemistry department for measurement of HbA1 (by HPLC method). All patients who are diagnosed with diabetes (or known to have diabetes) will have a foot examination and retinal and renal screening and cardiovascular assessment for diabetes complications.

Also known as: Foot examination and other screening for diabetes complications, Lipds and renal function

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients attending the accident and emergency department and acute medical wards of a district general hospital

You may qualify if:

• Aged ≥30 years.
• Males and female sex

You may not qualify if:

• Aged \<30 years.
• Type 1 diabetes

Sponsors & Collaborators

• Tameside General Hospital: lead

Study Sites (1)

Tameside Hospital NHS Foundation Trust

Ashton-under-Lyne, Greater Manchester, OL6 9RW, United Kingdom

Location

Related Publications (1)

• Jude EB, Saluja S, Heald A, Widiatmoko D, Schaper N, Anderson SG. Improving Diabetes and Pre-Diabetes Detection in the UK: Insights From HbA1c Screening in an Acute Hospital's Emergency Department. Diabetes Ther. 2025 Oct;16(10):1917-1932. doi: 10.1007/s13300-025-01777-w. Epub 2025 Aug 6.

  PMID: 40768193 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Kidney Function Tests

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Urological; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Edward Jude

  Tameside and Glossop Integrated Care NHS FT

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 25, 2020
• First Posted: December 4, 2020
• Study Start: February 1, 2022
• Primary Completion: April 24, 2025
• Study Completion: April 24, 2025
• Last Updated: September 9, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)