NCT04611854

Brief Summary

Internet-delivered cognitive behaviour therapy (ICBT) shows promise as a method of treating alcohol misuse. In this form of treatment, patients complete online lessons over several weeks that assist patients in developing skills to address alcohol misuse. ICBT can be offered to patients in a self-guided format or with guidance. Self-guided ICBT allows users to complete lessons by themselves without any contact with a guide. Guided ICBT involves having support from a guide in the form of emails, online messages and/or brief telephone calls. In some studies, guided-ICBT has shown greater reductions in alcohol consumption than self-guided ICBT. To date, there has been limited research on patient preferences for these varying levels of support when ICBT is offered as part of routine health care. This represents an important research direction as there is some past research showing that patients' treatment preferences can affect study enrollment, attrition, adherence, satisfaction, and outcomes. This study will investigate patient preferences for self-guided ICBT versus guided-ICBT and compare enrollment, attrition, adherence, and outcomes of the two approaches when patients select their treatment preferences. The study will also explore the extent to which preferences are related to patient background variables (e.g., duration, severity of problems, treatment goals in terms of patients wanting to cut-down on alcohol use versus to abstain from alcohol use). Furthermore, this study seeks to identify how ratings of effort and helpfulness throughout treatment vary depending on whether patients select self-guided versus guided ICBT. This study represents a pragmatic observational trial conducted in routine care and aims to increase understanding of how to implement ICBT within routine care.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 26, 2020

Completed
6 days until next milestone

Study Start

First participant enrolled

November 1, 2020

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 2, 2020

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 19, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 19, 2022

Completed
Last Updated

December 4, 2023

Status Verified

November 1, 2023

Enrollment Period

1.8 years

First QC Date

October 26, 2020

Last Update Submit

November 30, 2023

Conditions

Keywords

Internet-delivered Cognitive Behaviour TherapyGuidanceAlcohol Misuse

Outcome Measures

Primary Outcomes (2)

  • Drinks in preceding week as measured by Timeline Followback (TLFB)

    Change in preceding week alcohol consumption in terms of the total number of standard drinks consumed on each day during the previous 7 days.

    Screening, Pre-treatment, 4 weeks (mid-treatment), 8 weeks (post-treatment), 3 months after treatment

  • Heavy drinking days preceding week as measured by Timeline Followback (TLFB)

    Change in preceding week alcohol consumption in terms of the total number of heavy drinking days during the previous 7 days.

    Screening, Pre-treatment, 4 weeks (mid-treatment), 8 weeks (post-treatment), 3 months after treatment

Secondary Outcomes (10)

  • Alcohol Use Disorders Identification Test (AUDIT)

    Screening, 8 weeks (post-treatment), 3 months after treatment

  • Penn Alcohol Craving Scale

    Screening, 8 weeks (post-treatment), 3 months after treatment, 6 months after treatment, 12 months after treatment

  • Brief Situational Confidence Questionnaire (BSCQ)

    Screening, 8 weeks (post-treatment), 3 months after treatment

  • Generalized Anxiety Disorder 7-item (GAD-7)

    Screening, 8 weeks (post-treatment), 3 months after treatment

  • Patient Health Questionnaire (PHQ-9)

    Screening (Pre-treatment), 4 weeks (mid-treatment), 8 weeks (post-treatment), 3 months after treatment

  • +5 more secondary outcomes

Study Arms (2)

ICBT for alcohol misuse: Guidance

ACTIVE COMPARATOR

In this arm, participants will receive the 8-week internet-delivered cognitive behaviour therapy (ICBT) course for alcohol misuse with guidance from a health educator through regular weekly online messages. Participants may also be contacted through emails and phone calls. The team of guides consists of registered social workers, psychologists, and graduate students, with experience delivering ICBT.

Behavioral: GuidanceBehavioral: ICBT for alcohol misuse

ICBT for alcohol misuse: Self-Guidance

EXPERIMENTAL

Participants who select this arm will receive the 8-week internet-delivered cognitive behaviour therapy (ICBT) course for alcohol misuse. Participants are able to contact the Online Therapy Unit regarding any technical issues with logging onto the site. However, no guidance from a health educator will be provided. Clients will be monitored by providing brief measures on alcohol each week and measures of depression and anxiety administered at the beginning of week 5. However, clients will only be contacted if there is a significant clinical issue requiring attention (e.g., sudden increase in symptoms of depression and suicidal ideation).

Behavioral: ICBT for alcohol misuse

Interventions

GuidanceBEHAVIORAL

Guidance from a health educator through regular weekly online messages. Participants may also be contacted through emails and phone calls. The team of guides consists of registered social workers, psychologists, and graduate students, with experience delivering ICBT.

ICBT for alcohol misuse: Guidance

The 8-week internet-delivered cognitive behaviour therapy (ICBT) course for alcohol misuse. The course consists of 8 lessons distributed across 8 weeks.

ICBT for alcohol misuse: GuidanceICBT for alcohol misuse: Self-Guidance

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Timeline Followback (TLFB; preceding week alcohol consumption) \> 13 drinks
  • Alcohol Use Disorders Identification Test (AUDIT) \> 7

You may not qualify if:

  • Suicidal ideation (measured by scoring \> 2 to question 9 of PHQ-9)
  • Severe mental health or medical conditions
  • Severe drug use problems (measured by scoring \> 24 on Drug Use Disorders Identification Test \[DUDIT\] or clinical assessment)
  • Low motivation to do, or concerns regarding, online treatment
  • Ongoing or impending significant mental health treatment
  • Not residing in Saskatchewan Canada for the duration of treatment
  • Lack of or inconsistent access to a computer and internet at home or private place for the duration of treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Online Therapy Unit, University of Regina

Regina, Saskatchewan, S4S 0A2, Canada

Location

Related Publications (1)

  • Sapkota RP, Lozinski T, Wilhems A, Nugent M, Schaub MP, Keough MT, Sundstrom C, Hadjistavropoulos HD. Internet-delivered therapy for alcohol misuse: engagement, satisfaction, and outcomes when patients select their preference for therapist- or self-guided treatment. Addict Sci Clin Pract. 2024 Apr 20;19(1):30. doi: 10.1186/s13722-024-00456-8.

MeSH Terms

Conditions

Alcoholism

Interventions

CounselingEthanol

Condition Hierarchy (Ancestors)

Alcohol-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Mental Health ServicesBehavioral Disciplines and ActivitiesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and ServicesAlcoholsOrganic Chemicals

Study Officials

  • Heather Hadjistavropoulos, PhD

    University of Regina

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Each client will select either self-guided or guided option.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 26, 2020

First Posted

November 2, 2020

Study Start

November 1, 2020

Primary Completion

August 19, 2022

Study Completion

August 19, 2022

Last Updated

December 4, 2023

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will share

Other researchers may ask to review IPD from this trial following completion of data collection. For the purposes of meta-analyses or other legitimate uses, IPD will be provided after being fully de-identified.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
Data will be available for a period beginning 6 months after the conclusion of the trial until 5 years have elapsed.
Access Criteria
Data will be provided to researchers who provide a methodologically sound proposal and present a request for data that is within our operational capacity to provide. Additionally, researchers must provide information about how they will use and store the data, as well as sign an agreement related to the use of the data.

Locations