Blended Treatment for Alcohol Use Disorder

NCT04535258 | Active Not Recruiting

• 1 other identifier: BLEND-A
• Study Type: interventional
• Target: 1,800
• Locations: 1 country
• Sites: 1

Brief Summary

Blended Treatment for Alcohol Use Disorder (BLEND-A) is a pragmatic, cluster randomized controlled trial to assess the clinical effectiveness and cost-effectiveness of implementing a blended treatment format that aims to reduce problematic alcohol use. Blended treatment is a treatment format where treatment as usual is offered as a combination of online and face-to-face sessions, integrated into one treatment protocol. The BLEND-A study will evaluate and implement a blended treatment program in routine alcohol addiction treatment. The trial is led by Unit of Clinical Alcohol Research, University of Southern Denmark (UCAR) in collaboration with partners at the Centre for Telepsychiatry in the Region of Southern Denmark (CTP), and Sundhed.dk.

Conditions

Alcohol Use Disorder

Outcome Measures

Primary Outcomes (2)

• Compliance and premature dropout in alcohol treatment

  BLEND-A (outpatient treatment as usual offered as a combination between face-to face and internet-based sessions) leads to a change in compliance in treatment during one year following initiation of treatment, compared to TAU (usual treatment delivered as face-to-face outpatient treatment only ), and measured as a change in premature dropout of treatment in the National Register of alcohol treatment (NAB).

  One year after enrolled in the study

• Effectiveness of alcohol treatment

  The effectiveness of BLEND-A compared to TAU, measured by alcohol intake 6 months after treatment start. The alcohol intake is measured by self-reported alcohol intake.

  6 months after enrolled in the study

Secondary Outcomes (3)

• Differences in Quality of Life according to the intervention

  6 months after enrolled in the study

• Which part of treatment is appreciated to receive via the internet

  Through study completion, an average of 1 year

• Optimal blend

  Through study completion, an average of 1 year

Other Outcomes (1)

• Qualitative interviews

  Through study completion, an average of 1 year

Study Arms (4)

First-movers

OTHER

The first four alcohol clinics offers internet-based treatment to the patients who chooses the proportion of internet-based sessions.

Device: Blend-A

Second-movers

OTHER

After three months, the next five alcohol clinics offers internet-based treatment to the patients who chooses the proportion of internet-based sessions.

Device: Blend-A

Third-movers

OTHER

After three months, the next five alcohol clinics offers internet-based treatment to the patients who chooses the proportion of internet-based sessions.

Device: Blend-A

Fourth-movers

OTHER

After three months, the last four alcohol clinics offers internet-based treatment to the patients who chooses the proportion of internet-based sessions.

Device: Blend-A

Interventions

Blend-A DEVICE

Treatment for alcohol use disorders will be offered also as an internet-based option.

First-movers; Fourth-movers; Second-movers; Third-movers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Legal person seeking public alcohol treatment in the participating municipalities.

You may not qualify if:

• None.

Sponsors & Collaborators

• University of Southern Denmark: lead
• Region of Southern Denmark: collaborator

Study Sites (1)

Unit if Clinical Alcohol Research

Odense, 5000, Denmark

Location

Related Publications (2)

• Tarp K, Christiansen R, Bilberg R, Borkner S, Dalsgaard C, Paldam Folker M, Sogaard Nielsen A. Patient Perspectives on Blended Internet-Based and Face-to-Face Cognitive Behavioral Therapy for Alcohol Use Disorder: Qualitative Study. J Med Internet Res. 2024 Oct 23;26:e47083. doi: 10.2196/47083.

  PMID: 39441642 DERIVED

• Mellentin AI, Behrendt S, Bilberg R, Blankers M, Folker MP, Tarp K, Uffelmann J, Nielsen AS. BLEND-A: blending internet treatment into conventional face-to-face treatment for alcohol use disorder - a study protocol. BMC Psychiatry. 2021 Mar 6;21(1):131. doi: 10.1186/s12888-021-03122-4.

  PMID: 33676429 DERIVED

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Anette S. Nielsen, PhD

  University of Southern Denmark

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Stepped-wedge cluster randomized (18 institutions, 4 waves)

Study Record Dates

• First Submitted: April 24, 2020
• First Posted: September 1, 2020
• Study Start: June 1, 2020
• Primary Completion: June 30, 2022
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 29, 2026

Record last verified: 2026-04

Locations

DK (1)