NCT04609904

Brief Summary

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
2,187

participants targeted

Target at P75+ for phase_3 asthma

Timeline
Completed

Started Mar 2021

Longer than P75 for phase_3 asthma

Geographic Reach
16 countries

317 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 26, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 30, 2020

Completed
4 months until next milestone

Study Start

First participant enrolled

March 1, 2021

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 20, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 20, 2025

Completed
Last Updated

April 20, 2025

Status Verified

April 1, 2025

Enrollment Period

4.1 years

First QC Date

October 26, 2020

Last Update Submit

April 18, 2025

Conditions

Outcome Measures

Primary Outcomes (2)

  • Change from baseline in forced expiratory volume in 1 second (FEV1) area under the curve 0 to 3 hours (AUC0-3) at Week 24

    Change from baseline in forced expiratory volume in 1 second (FEV1) area under the curve 0 to 3 hours (AUC0-3) at Week 24

    24 Weeks

  • Rate of severe asthma exacerbations

    Primary end point(s) of Pooled Studies D5982C00007 and D5982C00008: Rate of severe asthma exacerbations

    Up to 52 Weeks

Secondary Outcomes (11)

  • Change from baseline in morning pre-dose trough FEV1 at Week 24

    24 Weeks

  • Percentage of responders in Asthma Control Questionnaire (ACQ)-7 (≥0.5 decrease equals response) at Week 24

    24 Weeks

  • Percentage of responders in ACQ-5 (≥0.5 decrease equals response) at Week 24

    24 Weeks

  • Percentage of responders in the Asthma Quality of Life Questionnaire for 12 years and older (AQLQ +12) (≥0.5 increase equals response) at Week 24

    24 Weeks

  • Percentage of responders in the St. George's Respiratory Questionnaire (SGRQ) (≥4.0 unit decrease equals response) at Week 24

    24 Weeks

  • +6 more secondary outcomes

Study Arms (4)

Budesonide, glycopyrronium, and formoterol fumarate (BGF) MDI 320/28.8/9.6 μg

EXPERIMENTAL

BGF MDI 320/28.8/9.6 μg Budesonide, glycopyrronium, and formoterol fumarate (PT010) Metered Dose Inhaler (MDI)

Drug: BGF MDI 320/28.8/9.6 μg

BGF MDI 320/14.4/9.6 μg

EXPERIMENTAL

BGF MDI 320/14.4/9.6 μg Budesonide, glycopyrronium, and formoterol fumarate (PT010) Metered Dose Inhaler (MDI)

Drug: BGF MDI 320/14.4/9.6 μg

Budesonide and formoterol fumarate (BFF) MDI 320/9.6 μg

ACTIVE COMPARATOR

BFF MDI 320/9.6 μg (Experimental/Comparator) Budesonide and formoterol fumarate (PT009) Metered Dose Inhaler (MDI)

Drug: BFF MDI 320/9.6 μg

Symbicort®

ACTIVE COMPARATOR

Budesonide/ formoterol fumarate pressurized metered dose inhaler (pMDI) 320/9 μg

Drug: BFF pMDI 320/9 μg

Interventions

Budesonide, glycopyrronium, and formoterol fumarate metered dose inhaler

Also known as: BGF
Budesonide, glycopyrronium, and formoterol fumarate (BGF) MDI 320/28.8/9.6 μg

Budesonide, glycopyrronium, and formoterol fumarate metered dose inhaler

Also known as: BGF
BGF MDI 320/14.4/9.6 μg

Budesonide and formoterol fumarate metered dose inhaler

Also known as: BFF
Budesonide and formoterol fumarate (BFF) MDI 320/9.6 μg

Budesonide/formoterol fumarate pressurized metered dose inhaler

Also known as: Symbicort®
Symbicort®

Eligibility Criteria

Age12 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • to 80 years of age, male and female, BMI \<40 kg/m2; females must be not of childbearing potential or using a form of highly effective birth control.
  • Documented history of physician-diagnosed asthma \> and/or = 1 year prior to V1.
  • Regularly using a stable daily ICS/LABA regimen (including a stable ICS dose) with medium-to-high ICS doses for at least 4 weeks prior to V1.
  • ACQ-7 total score ≥1.5 at Visits 1, 3, and 5 (pre-randomization).
  • FEV1 % (assessed as an average of the 60 and 30 minute pre-dose assessments) predicted normal at V1, 2, 3, 4, and 5 (pre-randomization)
  • Participants \> and/or = 18 years of age: \< 80%
  • Participants 12 to \<18 years of age: \< 90%
  • FEV1 post-albuterol at V2 or V3 (if repeat needed). • Participants \> and/or = 18 years of age: Increase \> and/or = 12% and \> and/or = 200 mL.
  • Participants 12 to \<18 years of age: Increase =12% either in the 12 months prior to Visit 1 or at Visit 2, or at Visit 3.
  • Note: Even if there is documented history of reversibility, all participants must be assessed for reversibility at Visit 2 (and Visit 3, if reversibility is not demonstrated at Visit 2) to provide reversibility baseline data for characterization.
  • Willing and, in the opinion of the Investigator, able to adjust current asthma therapy, as required by the protocol.
  • Demonstrate acceptable MDI/pMDI administration technique.
  • Received no asthma medication other than run-in BFF MDI BID and albuterol as needed during screening (except for allowed medications as defined in Table 9 and systemic corticosteroid or ICS for the treatment of an asthma exacerbation).
  • eDiary 14-day compliance ≥70% during screening (defined as completing the daily eDiary for any 10 mornings and any 10 evenings and answering "Yes" to taking 2 puffs of run-in BFF MDI for any 10 mornings and 10 evenings in the last 14 days prior to randomization).
  • No respiratory infection in the 4 weeks prior to randomization, or asthma exacerbation treated with systemic corticosteroid and/or additional ICS treatment in the 4 weeks prior to randomization.

You may not qualify if:

  • \. Completed treatment for respiratory infection or asthma exacerbation with systemic corticosteroids within 4 weeks of V1.
  • a. Participants where, in the opinion of the Investigator, treatment with biological therapy for asthma would be appropriate.
  • b. Any marketed or investigational biologics within 3 months or 5 halflives of V1, whichever is longer and must not be used during study duration.
  • \. Current smokers, former smokers with \>10 pack-years history, or former smokers who stopped smoking \<6 months prior to V1 (including all forms of tobacco, e-cigarettes or other vaping devices, and marijuana).
  • \. Current evidence of COPD.
  • a. Oral and IV corticosteroid use (any dose) within 4 weeks of V1.
  • b. Use of systemic corticosteroids for any other reason except for the acute treatment of severe asthma exacerbation is prohibited for the duration of the study.
  • c. Depot corticosteroid use for any reason within 3 months of V1.
  • \. Use of LAMA, either alone or as part of an inhaled combination therapy, in the 12 weeks prior to Visit 1.
  • \. Use of oral beta2-agonist within 3 months of V1.
  • \. Use of any immunomodulators or immunosuppressive medication within 3 months or 5 half-lives, whichever is longer, and must not be used during the study duration.
  • \. Narrow angle glaucoma not adequately treated and/or change in vision that may be relevant, in the opinion of the Investigator, within 3 months of Visit 1.
  • \. Life-threatening asthma defined as a history of significant asthma episode(s) requiring intubation associated with hypercapnia, respiratory arrest, hypoxic seizures, or asthma-related syncopal episode(s).
  • \. Hospitalization for asthma within 2 months of Visit 1.
  • \. Known history of drug or alcohol abuse within 12 months of Visit 1.
  • +6 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (317)

Research Site

Chandler, Arizona, 85224, United States

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Tempe, Arizona, 85283, United States

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Tucson, Arizona, 85741, United States

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Hot Springs, Arkansas, 71913, United States

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Bakersfield, California, 93301, United States

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Carlsbad, California, 92008, United States

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Huntington Beach, California, 92647, United States

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Lancaster, California, 93534, United States

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Long Beach, California, 90815, United States

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Mission Viejo, California, 92691, United States

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North Hollywood, California, 91606, United States

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Northridge, California, 91324, United States

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Rancho Cucamonga, California, 91730, United States

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Sacramento, California, 95823, United States

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San Diego, California, 92123, United States

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San Jose, California, 95117, United States

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Ventura, California, 93003, United States

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Walnut Creek, California, 94598, United States

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Colorado Springs, Colorado, 80907, United States

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Colorado Springs, Colorado, 80910, United States

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Wheat Ridge, Colorado, 80033, United States

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Newark, Delaware, 19713, United States

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Boca Raton, Florida, 33487, United States

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Clearwater, Florida, 33756, United States

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Clearwater, Florida, 33765, United States

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Cutler Bay, Florida, 33189, United States

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DeBary, Florida, 32713, United States

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Hialeah, Florida, 33016, United States

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Lakeland, Florida, 33813, United States

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Miami, Florida, 33135, United States

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Tampa, Florida, 33615, United States

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Acworth, Georgia, 30101, United States

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Atlanta, Georgia, 30322, United States

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Atlanta, Georgia, 30350, United States

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Snellville, Georgia, 30078, United States

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Boise, Idaho, 83706, United States

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Chicago, Illinois, 60621, United States

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Normal, Illinois, 61761, United States

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Peoria, Illinois, 61636, United States

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Evansville, Indiana, 47715, United States

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Marrero, Louisiana, 70072, United States

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Zachary, Louisiana, 70791, United States

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Baltimore, Maryland, 21224, United States

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White Marsh, Maryland, 21162, United States

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Fall River, Massachusetts, 02723, United States

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Farmington Hills, Michigan, 48336, United States

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Rochester, Michigan, 48307, United States

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Troy, Michigan, 48085, United States

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St Louis, Missouri, 63141, United States

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Warrensburg, Missouri, 64093, United States

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North Las Vegas, Nevada, 89030, United States

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Portsmouth, New Hampshire, 03801, United States

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Ocean City, New Jersey, 07712, United States

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Albuquerque, New Mexico, 87102, United States

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Brooklyn, New York, 11236, United States

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The Bronx, New York, 10459, United States

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The Bronx, New York, 10461, United States

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The Bronx, New York, 10468, United States

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Greensboro, North Carolina, 27405, United States

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Huntersville, North Carolina, 28078, United States

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Monroe, North Carolina, 28112, United States

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Columbus, Ohio, 43215, United States

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Portland, Oregon, 97202, United States

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Jenkintown, Pennsylvania, 19046, United States

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Philadelphia, Pennsylvania, 19107, United States

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Spartanburg, South Carolina, 29303, United States

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Knoxville, Tennessee, 37909, United States

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Amarillo, Texas, 79106, United States

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Cedar Park, Texas, 78613, United States

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Dallas, Texas, 75254, United States

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Denison, Texas, 75020, United States

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Forney, Texas, 75126, United States

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Houston, Texas, 77074, United States

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Houston, Texas, 77099, United States

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Lewisville, Texas, 75067, United States

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McKinney, Texas, 75069, United States

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North Richland Hills, Texas, 76180, United States

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Pearland, Texas, 77584, United States

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Plano, Texas, 75093, United States

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San Antonio, Texas, 78258, United States

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Sugar Land, Texas, 77478, United States

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Victoria, Texas, 77901, United States

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Roy, Utah, 84067, United States

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Abingdon, Virginia, 24210, United States

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Burke, Virginia, 22015, United States

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Williamsburg, Virginia, 23188, United States

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Milwaukee, Wisconsin, 53226, United States

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Milwaukee, Wisconsin, 53228, United States

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Botucatu, 18618-970, Brazil

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Porto Alegre, 9002-060, Brazil

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Porto Alegre, 90430-001, Brazil

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Porto Alegre, 90610-000, Brazil

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Porto Alegre, 91350-200, Brazil

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Santo André, 09080-110, Brazil

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São Paulo, 05403-000, Brazil

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Sorocaba, 18040-425, Brazil

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Baotou, 014010, China

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Beijing, 100020, China

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Changsha, 410005, China

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Changsha, 410008, China

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Changsha, 430033, China

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Changzhi, 46000, China

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Chengdu, 610072, China

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Chengdu, 611130, China

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Chizhou, 247099, China

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Chongqing, 400010, China

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Chongqing, 400038, China

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Dongguan, 523413, China

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Dongyang, 322100, China

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Fuzhou, 350025, China

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Guangzhou, 510062, China

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Guangzhou, 510100, China

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Guangzhou, 510120, China

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Guangzhou, 510180, China

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Guangzhou, 510280, China

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Guangzhou, 510630, China

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Haikou, 570208, China

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Haikou, 570311, China

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Hangzhou, 310005, China

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Hangzhou, 310009, China

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Hefei, 230000, China

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Hefei, 230011, China

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Hefei, 230061, China

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Huai'an, 223300, China

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Huizhou, 516001, China

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Jinan, 250014, China

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Jinhua, 321000, China

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Kunming, 650032, China

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Kunming, 650051, China

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Lanzhou, 730000, China

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Liuchow, 545006, China

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Luoyang, 471003, China

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Nanchang, 330006, China

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Nanchong, 637000, China

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Nanjing, 210006, China

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Nanjing, 210008, China

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Nanjing, 210009, China

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Nanjing, 210029, China

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Nanning, 530021, China

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Qingdao, 266000, China

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Qingdao, 266042, China

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Shanghai, 200025, China

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Shanghai, 200032, China

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Shanghai, 200065, China

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Shanghai, 200080, China

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Shanghai, 200092, China

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Shanghai, 200240, China

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Shanghai, 201199, China

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Shaoxing, 312000, China

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Shengyang, 110004, China

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Shenyang, 110001, China

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Shenyang, 110015, China

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Shenyang, 110075, China

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Shenzhen, 518020, China

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Shenzhen, 518036, China

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Shenzhen, 518039, China

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Shijiazhuang, 50051, China

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Taiyuan, 030001, China

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Taiyuan, 030032, China

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Taizhou, 318020, China

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Ürümqi, 830054, China

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Weifang, 261000, China

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Wuhan, 430010, China

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Wuhan, 430030, China

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Wuhu, 241000, China

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Xi'an, 710004, China

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Xi'an, 710077, China

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Xinxiang, 453002, China

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Xuzhou, 221000, China

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Xuzhou, 221009, China

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Yangzhou, 225001, China

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Yantai, 264000, China

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Yinchuan, 750001, China

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Yinchuan, 750004, China

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Yueyang, 414000, China

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Zhangzhou, 363099, China

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Zhanjiang, 524001, China

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Zhengzhou, 450000, China

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Zhuji, 311899, China

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Barranquilla, 080020, Colombia

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Bogotá, 110221, Colombia

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Cartagena, 130013, Colombia

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Medellín, 050621, Colombia

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Rionegro, 054047, Colombia

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Brandýs nad Labem, 250 01, Czechia

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Jindřichův Hradec, 377 01, Czechia

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Lovosice, 410 02, Czechia

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Mladá Boleslav, 293 01, Czechia

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Nový Bor, 473 01, Czechia

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Prague, 148 00, Czechia

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Prague, 190 00, Czechia

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Rokycany, 337 22, Czechia

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Strakonice, 38601, Czechia

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Teplice, 415 01, Czechia

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Varnsdorf, 407 47, Czechia

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Bamberg, 96049, Germany

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Berlin, 10119, Germany

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Berlin, 10367, Germany

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Berlin, 10717, Germany

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Berlin, 10787, Germany

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Berlin, 12159, Germany

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Berlin, 12203, Germany

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Berlin, 13187, Germany

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Darmstadt, 64283, Germany

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Frankfurt, 60596, Germany

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Frankfurt am Main, 60389, Germany

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Frankfurt am Main, 60596, Germany

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Fürstenwalde, 15517, Germany

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Geesthacht, 21502, Germany

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Hanover, 30449, Germany

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Hanover, D-30173, Germany

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Heidelberg, 69115, Germany

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Koblenz, 56068, Germany

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Landsberg, 86899, Germany

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Leipzig, 04103, Germany

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Leipzig, 04207, Germany

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Leipzig, 04299, Germany

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Mainz, 55128, Germany

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München-Pasing, 81241, Germany

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Witten, 58452, Germany

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Alexandroupoli, 68100, Greece

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Athens, 11521, Greece

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Athens, 11527, Greece

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Athens, 12462, Greece

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Athens, 17562, Greece

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Corfu, 49100, Greece

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Exohi Thessaloniki, 57010, Greece

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Ioannina, 45500, Greece

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Pátrai, 26500, Greece

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Thessaloniki, 56429, Greece

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Thessaloniki, 57010, Greece

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Ashkelon, 7830604, Israel

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Beersheba, 84101, Israel

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Haifa, 31096, Israel

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Haifa, 34362, Israel

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Holon, 5837738, Israel

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Jerusalem, 9103102, Israel

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Jerusalem, 9112001, Israel

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Kfar Saba, 4428164, Israel

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Petah Tikva, 4920235, Israel

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Rehovot, 76100, Israel

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Tel Aviv, 6423906, Israel

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Cuernavaca, 62290, Mexico

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Durango, 43080, Mexico

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Guadalajara, 44200, Mexico

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Mazatlán, 82000, Mexico

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Mérida, 97070, Mexico

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Monterrey, 64620, Mexico

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Monterrey, 64710, Mexico

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Monterrey, 64718, Mexico

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Veracruz, 91910, Mexico

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Villahermosa, 86035, Mexico

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Zapopan, 45138, Mexico

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Amadora, 2720-276, Portugal

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Braga, 4710, Portugal

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Coimbra, 3040-316, Portugal

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Figueira da Foz Municipality, 3094-001, Portugal

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Guimarães, 4835-044, Portugal

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Lisbon, 1649-035, Portugal

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Lisbon, 1998-018, Portugal

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Matosinhos Municipality, 4454-509, Portugal

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Ponce, 00717, Puerto Rico

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Ponce, 00780, Puerto Rico

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Chelyabinsk, 454106, Russia

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Izhevsk, 426035, Russia

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Kazan', 420008, Russia

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Kemerovo, 650002, Russia

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Moscow, 115522, Russia

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Moscow, 125284, Russia

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Omsk, 644050, Russia

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Penza, 440067, Russia

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Perm, 614000, Russia

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Saint Petersburg, 194354, Russia

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Saint Petersburg, 195257, Russia

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Saratov, 410028, Russia

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Saratov, 410053, Russia

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Tomsk, 634050, Russia

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Ulyanovsk, 432009, Russia

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Bojnice, 972 01, Slovakia

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Kežmarok, 060 01, Slovakia

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Košice, 04022, Slovakia

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Levice, 934 01, Slovakia

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Levice, 93401, Slovakia

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Nové Zámky, 94001, Slovakia

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Poprad, 058 01, Slovakia

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Prešov, 081 81, Slovakia

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Ružomberok, 034 26, Slovakia

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Šurany, 94201, Slovakia

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Topoľčany, 95501, Slovakia

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Žilina, 010 01, Slovakia

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Bloemfontein, 9301, South Africa

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Cape Town, 7700, South Africa

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Cape Town, 7764, South Africa

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Durban, 4001, South Africa

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Durban, 4091, South Africa

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Durban, 4093, South Africa

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Durban, 4450, South Africa

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eMkhomazi, 4170, South Africa

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Johannesburg, 2001, South Africa

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Lenasia, 1821, South Africa

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Lenasia Ext8, 1820, South Africa

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Panorama, 7500, South Africa

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Pretoria, 0186, South Africa

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Tygervalley, 7530, South Africa

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Adana, 1260, Turkey (Türkiye)

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Ankara, 06, Turkey (Türkiye)

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Istanbul, 34098, Turkey (Türkiye)

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Istanbul, 34844, Turkey (Türkiye)

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Izmir, 35110, Turkey (Türkiye)

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Mersin, 33343, Turkey (Türkiye)

Location

Research Site

Pamukkale, 20070, Turkey (Türkiye)

Location

Research Site

Blackpool, FY3 7EN, United Kingdom

Location

Research Site

Bradford, BD9 6RJ, United Kingdom

Location

Research Site

Corby, NN17 2UR, United Kingdom

Location

Research Site

Hull, HU16 5JQ, United Kingdom

Location

Research Site

Leicester, LE5 4LJ, United Kingdom

Location

Research Site

Rhyl, LL18 1DA, United Kingdom

Location

Related Publications (1)

  • Oba Y, Anwer S, Maduke T, Patel T, Dias S. Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying doses of inhaled corticosteroids in adolescents and adults with asthma: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2022 Dec 6;12(12):CD013799. doi: 10.1002/14651858.CD013799.pub2.

MeSH Terms

Conditions

Asthma

Interventions

Budesonide, Formoterol Fumarate Drug Combination

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Intervention Hierarchy (Ancestors)

Formoterol FumarateEthanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsAminesBudesonidePregnenedionesPregnenesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsDrug CombinationsPharmaceutical Preparations

Study Officials

  • Robert Wise, MD

    Johns Hopkins University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 26, 2020

First Posted

October 30, 2020

Study Start

March 1, 2021

Primary Completion

March 20, 2025

Study Completion

March 20, 2025

Last Updated

April 20, 2025

Record last verified: 2025-04

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
Access Criteria
When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
More information

Locations