NCT04609449

Brief Summary

Prospective study including patients submitted to RYGB (n=94) and L-RYGB (n=94) at a single institution. The aim was to compare the effect on comorbidities and weight loss of a long biliopancreatic limb Roux-en-Y gastric bypass (L-RYGB), compared with a standard RYGB. Procedure selection was randomly assigned (1:1), and surgeries were performed, during 24 months (2016-2017). Weight loss, comorbidities control and nutritional status were assessed at baseline and 12 months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
192

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2016

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2016

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2017

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2018

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

June 15, 2020

Completed
5 months until next milestone

First Posted

Study publicly available on registry

October 30, 2020

Completed
Last Updated

November 5, 2020

Status Verified

November 1, 2020

Enrollment Period

1.9 years

First QC Date

June 15, 2020

Last Update Submit

November 3, 2020

Conditions

Outcome Measures

Primary Outcomes (4)

  • Weight loss

    Measures: Weight in kilograms

    12 months

  • Weight loss

    Measures: Body Mass Index

    12 months

  • Weight loss

    Measures: Percent of excess weight loss

    12 months

  • Weight loss

    Measures: Percent of total weight loss

    12 months

Secondary Outcomes (6)

  • Complete Diabetes Remission Rate

    12 months

  • Major early complications

    First 30 days

  • Major late complications

    2-12 months

  • Nutritional status

    12 months

  • Nutritional status

    12 months

  • +1 more secondary outcomes

Study Arms (2)

Long biliopancreatic limb

EXPERIMENTAL

Patients submitted to long biliopancreatic limb Roux-en-Y gastric bypass.

Procedure: Long biliopancreatic limb Roux-en-Y gastric bypass.

Standard biliopancreatic limb

ACTIVE COMPARATOR

Patients submitted to standard Roux-en-Y gastric bypass.

Procedure: Standard Roux-en-Y gastric bypass

Interventions

Long biliopancreatic limb Roux-en-Y gastric bypass.

Long biliopancreatic limb

Standard Roux-en-Y gastric bypass

Standard biliopancreatic limb

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patient submitted to bariatric surgery
  • All patients met the guidelines defined by the National Institutes of Health (NIH) consensus: BMI equal or greater to 40kg/m2 or BMI 35 - 40 kg/m2 with some comorbidity

You may not qualify if:

  • Patients with incomplete surgery data sheet and those submitted to other type of bariatric surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital General Tlahuac

Mexico City, Mexico

Location

Study Officials

  • Carlos Zerrweck, MD

    Head of Department. The Obesity Clinic at Hospital General Tlahuac

    STUDY DIRECTOR
  • Antonio Herrera, MD

    The Obesity Clinic at Hospital General Tlahuac

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor and Head of Department.

Study Record Dates

First Submitted

June 15, 2020

First Posted

October 30, 2020

Study Start

January 1, 2016

Primary Completion

December 1, 2017

Study Completion

December 1, 2018

Last Updated

November 5, 2020

Record last verified: 2020-11

Data Sharing

IPD Sharing
Will not share

Locations