NCT04600128

Brief Summary

Regular consumption of dairy products is found to negatively associated with metabolic diseases and improve body composition in long term studies and has positive effect on acute glycemia control and satiety. However, new Canada's Food Guide released in 2019 promotes a shift from traditional dairy products to plant-based dairy alternatives. The present study examines the effect of traditional dairy products in comparison with plant-based alternatives on glycemic response and satiety.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable obesity

Timeline
Completed

Started Nov 2019

Typical duration for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 18, 2019

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

October 21, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 23, 2020

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2022

Completed
Last Updated

October 13, 2022

Status Verified

October 1, 2022

Enrollment Period

2.2 years

First QC Date

October 21, 2020

Last Update Submit

October 12, 2022

Conditions

ObesityType 2 Diabetes Mellitus

Keywords

DairyYogurtCheesePostprandial glycaemiaSatietyPlant based dairy alternative

Outcome Measures

Primary Outcomes (1)

  • Change in blood glucose levels

    Blood glucose (mmol/L) is measured using finger prick capillary blood samples

    Starting at the beginning of each session (0 minutes before consumption of treatment) and every 15-30 minutes up to 160 minutes (time of completion of each session)

Other Outcomes (2)

  • Subjective appetite

    up to 160 minutes (time of completion of each session)

  • Insulin

    up to 160 minutes (time of completion of each session)

Study Arms (4)

Dairy-based Greek yogurt

ACTIVE COMPARATOR

Plain dairy-based Greek yogurt

Other: Dairy-based greek yogurt

Dairy-based cheddar cheese

ACTIVE COMPARATOR

Mild dairy-based cheddar cheese

Other: Dairy-based cheddar cheese

Plant-based Greek yogurt

ACTIVE COMPARATOR

Plain plant-based Greek yogurt

Other: Plant-based yogurt

Plant-based cheese

ACTIVE COMPARATOR

Medium cheddar plant-based cheese

Other: Plant-based cheese

Interventions

Dairy-based greek yogurtOTHER

Plain Greek yogurt (2% M.F; Danone, Boucherville, Quebec, Canada)

Dairy-based Greek yogurt
Dairy-based cheddar cheeseOTHER

Mild cheddar cheese (31% M.F. ; Armstrong, Saputo Dairy Products, Saint-Laurent, Quebec, Canada)

Dairy-based cheddar cheese
Plant-based yogurtOTHER

Plain Greek yogurt alternative (Daiya, Rupert Street, Vancouver, Canada)

Plant-based Greek yogurt
Plant-based cheeseOTHER

Medium cheddar style block (Daiya, Rupert Street, Vancouver, Canada)

Plant-based cheese

Eligibility Criteria

Age20 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • BMI of 18.5-24.9 kg/m\^2

You may not qualify if:

  • smoke
  • skip breakfast
  • lactose intolerant
  • allergic to study foods
  • dislike study foods
  • are not comfortable with finger pricking
  • take prescription medication less than a year
  • undergoing hormonal treatments for less than 1 year
  • trying to gain or lose weight
  • have diabetes or cardiovascular disease
  • restrained eaters (identified by a score of ≥ 11 using the Eating Habits Questionnaire)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Toronto

Toronto, Ontario, M5S 3H2, Canada

Location

Related Publications (1)

  • Da Silva N, Anderson G, Amr A, Vien S, Fabek H. A comparison of the effects of dairy products with their plant-based alternatives on metabolic responses in healthy young Canadian adults: a randomized crossover study. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-17. doi: 10.1139/apnm-2024-0158.

    PMID: 39146559DERIVED

MeSH Terms

Conditions

ObesityDiabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesEndocrine System Diseases

Study Officials

  • G. Harvey Anderson, PhD

    University of Toronto

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

October 21, 2020

First Posted

October 23, 2020

Study Start

November 18, 2019

Primary Completion

January 31, 2022

Study Completion

March 31, 2022

Last Updated

October 13, 2022

Record last verified: 2022-10

Locations

CA(1)