Sulphur Amino Acid Requirements in Adults >60 Years

NCT04595188 | Completed

• 1 other identifier: 1000071600
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to determine the requirements for the sulphur amino acids in adults over the age of 60 years:

1. 1.the total sulphur amino acid requirement as methionine only. Methionine is an essential amino acid.
2. 2.the minimum methionine requirement as methionine in the presence of excess dietary cysteine.

Conditions

Healthy

Keywords

elderly; amino acid requirement; methionine; cysteine; dietary requirement; sulphur amino acids

Outcome Measures

Primary Outcomes (1)

• Determination of total sulphur amino acid requirements in adults >60 years of age

  methionine requirement the presence of zero cysteine

  up to 24 months

Secondary Outcomes (1)

• Determination of minimum sulphur amino acid requirements in adults >60 years of age

  up to 24 months

Study Arms (1)

Sulphur amino acids in Adults > 60

EXPERIMENTAL

Total sulphur amino acid, as methionine only: all subjects will receive up to 7 methionine test levels, without dietary cysteine, assigned in random order. Minimum methionine, with excess dietary cysteine: all subjects will receive up to 7 methionine test levels, in the presence of excess and constant dietary cysteine, assigned in random order.

Other: Sulphur amino acids

Interventions

Sulphur amino acids OTHER

For the total sulphur amino acid requirement, there are 7 different methionine test levels (without dietary cysteine) ranging from 5 to 40 mg of methionine per kilogram body weight per day. For the minimum methionine requirement, there are 7 different methionine test levels (with excess dietary cysteine).

Sulphur amino acids in Adults > 60

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Consent provided
• Aged 60 to 90 years old
• In good general health as evidenced by medical history, physical health and blood draw
• Fasting blood glucose, hemoglobin A1c (HbA1c), urea, creatinine, vitamin-B6, vitamin- B12 and folate levels within normal ranges for age.
• Willingness to participate in the study.
• BMI \<30 kg/m2.

You may not qualify if:

• Presence of chronic disease and/or acute illness known to affect protein/amino acid metabolism (e.g. HIV, diabetes, cancer, liver or kidney disease, acute cold or flu)
• Taking medications known to affect protein/AA metabolism (e.g. steroids)
• Inability to tolerate the diet (i.e. allergy)
• Significant weight loss during the past month or consumption of weight reducing diets.
• Significant caffeine consumption (\>2 cups per day)
• Significant consumption of alcohol (\>1 drink per day i.e. 1 beer or ½ glass of wine).
• Unwilling to have blood drawn from a venous access, or using a ventilated hood indirect calorimeter for the purposes of the study.

Sponsors & Collaborators

• The Hospital for Sick Children: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

Location

Related Publications (1)

• Paoletti A, Pencharz PB, Ball RO, Kong D, Xu L, Elango R, Courtney-Martin G. The dietary requirement for total sulfur amino acids in adults aged >/=60 years appears to be higher in males than in females. Am J Clin Nutr. 2023 Sep;118(3):538-548. doi: 10.1016/j.ajcnut.2023.06.015. Epub 2023 Jun 24.

  PMID: 37356549 DERIVED

Study Officials

• Glenda Courtney-Martin, MSc, PhD, RD

  The Hospital for Sick Children

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Academic & Clinical Specialist, Project Investigator

Study Record Dates

• First Submitted: October 6, 2020
• First Posted: October 20, 2020
• Study Start: October 10, 2020
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: September 13, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)