NCT04585802

Brief Summary

A new approach to investigate suicidal processes belongs to the broader neurocognitive picture and are so-called implicit associations. In dual process models of information processing a second functioning mode, the automatic processing mode, complements the conscious processing. Suicidal persons tend to have a stronger implicit association with "death" than non-suicidal persons. In this study, implicit associations between different unconscious cognitive constructs are compared among suicidal and non-suicidal patients. Therefore, an adapted version of the computer-based reaction time task (IAT-S) will be used. Four different versions of IATs are tested in this study. In the first version the implicit association between "self / others" and "death / life" is assessed (1). The second and third version measures the emotional evaluation of "death" (2) and "life" (3). In addition, in the fourth version the implicit association between death / life and internal / external locus of control is assessed (4). The implicit associations of these four IAT-S versions are compared between three groups: patients with suicidal behavior, patients with suicidal ideation, and a clinical group without previous suicide attempts and without suicidal ideation. The following hypotheses are made: in all four versions of the IAT-S, patients with previous suicidal behavior will have stronger implicit associations: between "self" and "death" as well as "death" and "internal locus of control" compared to all other groups. With a more "positive" evaluation of "death" and a more "negative" evaluation of "life" than all other participants.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
447

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2020

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 27, 2020

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 23, 2020

Completed
21 days until next milestone

First Posted

Study publicly available on registry

October 14, 2020

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 26, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 26, 2024

Completed
Last Updated

July 18, 2025

Status Verified

July 1, 2025

Enrollment Period

4.5 years

First QC Date

September 23, 2020

Last Update Submit

July 15, 2025

Conditions

Keywords

Implicit Association Test

Outcome Measures

Primary Outcomes (1)

  • Implicit Association Test (IAT)

    The German version of the Suicide Implicit Association Test (Rath et al., 2018) is administered using a computer paradigm and is designed to measure implicit associations with death using D-values. D is an individual effect size assessment that reflects the comparative difficulty of performing the two response conditions of the IAT, with a value of 0 indicating that the tasks had equivalent performance (Greenwald et al., 2003). D has a theoretical minimum of -2 and maximum of +2 when blocks of the same size are compared (Nosek \& Sriram, 2007). The more positive the D-values, the stronger the association between the "self" and "death" than between the "self" and "life".

    One assessment at baseline after study information and informed consent was given

Secondary Outcomes (7)

  • Suicide Behaviors Questionnaire - Revised

    One assessment at baseline after study information and informed consent was given

  • Beck Scale for Suicide Ideation (BSS)

    One assessment at baseline after study information and informed consent was given

  • Beck Depression Inventory (BDI-II)

    One assessment at baseline after study information and informed consent was given

  • Mee-Bunney Psychological Pain Assessment Scale (MBPPAS)

    One assessment at baseline after study information and informed consent was given

  • Positive Mental Health Scale (PMH-scale)

    One assessment at baseline after study information and informed consent was given

  • +2 more secondary outcomes

Study Arms (4)

Suicide Attempters (1)

patients with a suicide attempt

Suicide Ideators (2)

patients with suicidal ideation

Clinical Control Group (3)

patients without suicide attempt and without suicide ideation

Healthy Control Group (4)

persons without suicide attempt and without suicide ideation, who do not have a psychiatric disorder

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients from the University Hospital of Psychiatry

You may qualify if:

  • Age 18-65 years
  • Ability and willingness to participate in the study
  • Ability to give consent

You may not qualify if:

  • Foreign language
  • Diagnostic criteria: Psychoses, strong cognitive impairments (e.g. dementia)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Psychiatry and Psychotherapy, University of Bern

Bern, 3008, Switzerland

Location

Related Publications (14)

  • Nock MK, Park JM, Finn CT, Deliberto TL, Dour HJ, Banaji MR. Measuring the suicidal mind: implicit cognition predicts suicidal behavior. Psychol Sci. 2010 Apr;21(4):511-7. doi: 10.1177/0956797610364762. Epub 2010 Mar 9.

    PMID: 20424092BACKGROUND
  • Pearce CM, Martin G. Locus of control as an indicator of risk for suicidal behaviour among adolescents. Acta Psychiatr Scand. 1993 Dec;88(6):409-14. doi: 10.1111/j.1600-0447.1993.tb03482.x.

    PMID: 8310847BACKGROUND
  • Rath D, Hallensleben N, Glaesmer H, Spangenberg L, Strauss M, Kersting A, Teismann T, Forkmann T. [Implicit Associations with Death: First Validation of the German Version of the Suicide Implicit Association Test (Suicide IAT)]. Psychother Psychosom Med Psychol. 2018 Mar;68(3-4):109-117. doi: 10.1055/s-0043-105070. Epub 2017 Jun 29. German.

    PMID: 28718868BACKGROUND
  • Everall, RD, Altrows, KJ, Paulson, BL. Creating a Future: A Study of Resilience in Suicidal Female Adolescents. Journal of Counseling & Development. 2006; 84(4): 461-470.

    BACKGROUND
  • Osman A, Bagge CL, Gutierrez PM, Konick LC, Kopper BA, Barrios FX. The Suicidal Behaviors Questionnaire-Revised (SBQ-R): validation with clinical and nonclinical samples. Assessment. 2001 Dec;8(4):443-54. doi: 10.1177/107319110100800409.

    PMID: 11785588BACKGROUND
  • Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996 Dec;67(3):588-97. doi: 10.1207/s15327752jpa6703_13.

    PMID: 8991972BACKGROUND
  • Beck AT, Steer RA. BSI, Beck Scale for Suicide Ideation. Psychological Corporation. 1993.

    BACKGROUND
  • Kliem S, Brähler E. Beck-Hoffnungslosigkeits-Skala. Deutsche Fassung. Göttingen:Hogrefe. 2016.

    BACKGROUND
  • Mee S, Bunney BG, Bunney WE, Hetrick W, Potkin SG, Reist C. Assessment of psychological pain in major depressive episodes. J Psychiatr Res. 2011 Nov;45(11):1504-10. doi: 10.1016/j.jpsychires.2011.06.011. Epub 2011 Aug 9.

    PMID: 21831397BACKGROUND
  • Lukat J, Margraf J, Lutz R, van der Veld WM, Becker ES. Psychometric properties of the Positive Mental Health Scale (PMH-scale). BMC Psychol. 2016 Feb 10;4:8. doi: 10.1186/s40359-016-0111-x.

    PMID: 26865173BACKGROUND
  • Kemper CJ, Beierlein C, Kovaleva A, Rammstedt B. Eine Kurzskala zur Messung von Kontrollüberzeugung: Die Skala lnternale-Externale Kontrollüberzeugung-4 (IE-4). GESIS Working Papers.2012; 2(19).

    BACKGROUND
  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57.

    PMID: 9881538BACKGROUND
  • Nosek BA, Sriram N. Faulty assumptions: A comment on Blanton, Jaccard, Gonzales, and Christie (2006). J Exp Soc Psychol. 2007 May;43(3):393-398. doi: 10.1016/j.jesp.2006.10.018.

    PMID: 18438456BACKGROUND
  • Greenwald AG, Nosek BA, Banaji MR. Understanding and using the implicit association test: I. An improved scoring algorithm. J Pers Soc Psychol. 2003 Aug;85(2):197-216. doi: 10.1037/0022-3514.85.2.197.

    PMID: 12916565BACKGROUND

MeSH Terms

Conditions

Suicidal IdeationSuicide, Attempted

Condition Hierarchy (Ancestors)

SuicideSelf-Injurious BehaviorBehavioral SymptomsBehavior

Study Officials

  • Anja C. Gysin-Maillart, PD

    University of Bern

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 23, 2020

First Posted

October 14, 2020

Study Start

May 27, 2020

Primary Completion

November 26, 2024

Study Completion

November 26, 2024

Last Updated

July 18, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations