NCT05996172

Brief Summary

The goal of this clinical trial is to improve the effective outpatient management of acute youth suicide risk by optimizing intervention components to build an efficient, evidence-based intervention that is responsive to the needs of, and coordinated with, providers in primary care settings. The main questions are:

  1. 1.What is the strongest combination of SOARS components associated with reduction in youth suicidal thoughts and behavior (STB)?
  2. 2.Do age and STB history moderate the impact of the effects of the SOARS intervention components?
  3. 3.Do therapeutic alliance, youth and caregiver self-efficacy account for changes in youth STBs?
  4. 4.What helps medical outpatient providers refer to SOARS and continue care after SOARS?

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
184

participants targeted

Target at P75+ for not_applicable

Timeline
18mo left

Started Nov 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress63%
Nov 2023Jan 2028

First Submitted

Initial submission to the registry

June 19, 2023

Completed
2 months until next milestone

First Posted

Study publicly available on registry

August 18, 2023

Completed
3 months until next milestone

Study Start

First participant enrolled

November 9, 2023

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2027

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2028

Last Updated

March 27, 2025

Status Verified

March 1, 2025

Enrollment Period

4.1 years

First QC Date

June 19, 2023

Last Update Submit

March 24, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Harkavy-Asnis Suicide Scale

    This measure assesses the frequency of suicidal ideation on a 5-point Likert scale, with 0 indicating "never" and 4 indicating "most or all of the time". Higher scores reflect higher severity and frequency of suicidal ideation.

    baseline, 1, and 2 month follow up

Secondary Outcomes (1)

  • Columbia Suicide Severity Rating Scale (C-SSRS)

    baseline, 1, & 2 month follow up

Study Arms (8)

CAMS Single Session Consultation (SSC)

ACTIVE COMPARATOR

CAMS is a clinical intervention designed to modify how clinicians engage, assess and plan treatment with suicidal patients. The foundational brief intervention that all participants will receive includes 1 90-minute session of CAMS assessment and planning interview with follow-up care navigation.

Behavioral: CAMS Single Session Consultation

CAMS SSC + Driver-Focused Skills Training

ACTIVE COMPARATOR

Specific skills are taught to youth based on CAMS drivers/case conceptualization of suicidality. Based on our pilot work, the common components of treatment include explicit coaching in skills informed by evidence-based treatments like Dialectical Behavior Therapy (DBT), Cognitive Behavioral Therapy (CBT), and Behavioral Activation (BA). Skills are drawn from the following 3 domains: emotion regulation and crisis survival skills (e.g., paced breathing, use of temperature and exercise to alter mood, Hope Box), behavioral activation strategies (e.g., goal-directed behavior, scheduling of activities, problem-solving) and communication skills (communication around suicidality, validation of self and others, making clear requests/DEAR MAN). Youth assigned to the Ongoing CAMS Intervention condition will receive three, 50-minute sessions that include the interim SSF and driver focused treatment encompassing skills instruction, in-session practice, and assigned homework.

Behavioral: CAMS Single Session ConsultationBehavioral: Driver Focused Skills Training

CAMS SSC + Caregiver Skills Building

ACTIVE COMPARATOR

Caregivers will receive 3, 30-minute modules across 3 sessions that provide explicit coaching in several skills. Module content will include 1) psychoeducation on suicidality and the escalation cycle and creation of a communication plan related to responding to youth suicidality (i.e., Crisis Escalation and Communication Plan); 2) positive communication and relationship building strategies including reflective listening, validation, and how to implement regular teen-directed one-on-one time; and 3) setting up behavioral expectations, house rules, and using positive reinforcement based contingency management in the home (i.e., targeted praise, using rewards to promote more effective behaviors). All modules will include didactic skill building, role-play of skill use with the therapist, and a check-in with the youth and youth therapist to collaboratively problem-solve barriers to use of skills.

Behavioral: CAMS Single Session ConsultationBehavioral: Caregiver Skills Training

CAMS SSC + Lethal Means Safety

ACTIVE COMPARATOR

The CAMS Therapeutic Assessment incorporates low levels of lethal means restriction (see above). Experimental Intervention Component 4 will provide a high level of lethal means restriction that includes the evaluation of the need for a lock box, the provision of a lock box if needed, structured process for evaluating home safety in each room of the house, specific directives to accomplish, follow up with the clinician, and problem-solving barriers to lethal means restriction over two, 30-minute modules delivered across 2 sessions.

Behavioral: CAMS Single Session ConsultationBehavioral: Lethal Means Safety

CAMS SSC + Driver Focused Skills Training + Caregiver training

ACTIVE COMPARATOR

This arm includes CAMS SSC, 3 sessions of youth facing driver focused skills, and 3 sessions of caregiver skills training.

Behavioral: CAMS Single Session ConsultationBehavioral: Driver Focused Skills TrainingBehavioral: Caregiver Skills Training

CAMS SSC + Driver Focused Skills Training + Lethal Means Safety

ACTIVE COMPARATOR

This arm includes the CAMS single session intervention, 3 sessions of skills training for the youth, and lethal means safety for caregiver.

Behavioral: CAMS Single Session ConsultationBehavioral: Driver Focused Skills TrainingBehavioral: Lethal Means Safety

CAMS SSC + Caregiver Skills Training + Lethal Mean Safety

ACTIVE COMPARATOR

The arm includes the CAMS single session intervention, 3 sessions caregiver skills training and lethal means safety.

Behavioral: CAMS Single Session ConsultationBehavioral: Caregiver Skills TrainingBehavioral: Lethal Means Safety

CAMS SSC + Driver Focused Skills Training + Caregiver Skills + Lethal Means Safety

ACTIVE COMPARATOR

This arm includes the single session intervention, youth skills training, caregiver skills training and lethal means safety.

Behavioral: CAMS Single Session ConsultationBehavioral: Driver Focused Skills TrainingBehavioral: Caregiver Skills TrainingBehavioral: Lethal Means Safety

Interventions

CAMS is a clinical intervention designed to modify how clinicians engage, assess and plan treatment with suicidal patients. The foundational brief intervention that all participants will receive includes 1 90-minute session of CAMS assessment and planning interview with follow-up care navigation. CAMS is based around a model of STB which states that youth become suicidal in response to overwhelming pain, and treatment identifies and targets the drivers of suicide as the primary focus of assessment and intervention.

CAMS SSC + Caregiver Skills BuildingCAMS SSC + Caregiver Skills Training + Lethal Mean SafetyCAMS SSC + Driver Focused Skills Training + Caregiver Skills + Lethal Means SafetyCAMS SSC + Driver Focused Skills Training + Caregiver trainingCAMS SSC + Driver Focused Skills Training + Lethal Means SafetyCAMS SSC + Driver-Focused Skills TrainingCAMS SSC + Lethal Means SafetyCAMS Single Session Consultation (SSC)

The CAMS approach focuses on therapeutic assessment, collaborative identification and treatment of the patient-defined STB drivers (i.e., the problems that make suicide compelling to the patient) and utilizes problem-focused treatment sessions to address the drivers in order to reduce the wish to die. In the SOARS brief intervention model, specific skills are taught to youth based on CAMS drivers/case conceptualization of suicidality.

CAMS SSC + Driver Focused Skills Training + Caregiver Skills + Lethal Means SafetyCAMS SSC + Driver Focused Skills Training + Caregiver trainingCAMS SSC + Driver Focused Skills Training + Lethal Means SafetyCAMS SSC + Driver-Focused Skills Training

Caregivers will receive 3, 30-minute modules across 3 sessions that provide explicit coaching in several skills adapted from evidence-based treatments for youth suicidality including DBT and CBT.48,49 Module content will include 1) psychoeducation on suicidality and the escalation cycle and creation of a communication plan related to responding to youth suicidality (i.e., Crisis Escalation and Communication Plan); 2) positive communication and relationship building strategies including reflective listening, validation, and how to implement regular teen-directed one-on-one time; and 3) setting up behavioral expectations, house rules, and using positive reinforcement based contingency management in the home (i.e., targeted praise, using rewards to promote more effective behaviors). All modules will include didactic skill building, role-play of skill use with the therapist, and a check-in with the youth and youth therapist to collaboratively problem-solve barriers to use of skills.

CAMS SSC + Caregiver Skills BuildingCAMS SSC + Caregiver Skills Training + Lethal Mean SafetyCAMS SSC + Driver Focused Skills Training + Caregiver Skills + Lethal Means SafetyCAMS SSC + Driver Focused Skills Training + Caregiver training

The CAMS Therapeutic Assessment incorporates low levels of lethal means restriction (see above). Experimental Intervention Component 4 will provide a high level of lethal means restriction that includes the evaluation of the need for a lock box, the provision of a lock box if needed, structured process for evaluating home safety in each room of the house, specific directives to accomplish, follow up with the clinician, and problem-solving barriers to lethal means safety over two, 30-minute modules delivered across 2 sessions.

CAMS SSC + Caregiver Skills Training + Lethal Mean SafetyCAMS SSC + Driver Focused Skills Training + Caregiver Skills + Lethal Means SafetyCAMS SSC + Driver Focused Skills Training + Lethal Means SafetyCAMS SSC + Lethal Means Safety

Eligibility Criteria

Age13 Years - 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Acute suicidal thoughts or past month suicide attempt as reported on positive responses to the Ask Suicide Screening Questionnaire (ASQ),

You may not qualify if:

  • urgent medical care secondary to self-injurious behavior, psychosis, eating disorder that requires full or partial inpatient care, or
  • intellectual disability warranting a different treatment pathway;
  • limited English, Spanish, Vietnamese, or Chinese proficiency that would interfere with ability to complete study assessments;
  • unwillingness to participate in psychotherapy,
  • caregiver unwilling or ineligible to participate;
  • and previous enrollment in SOARS program or other P50 project as to not confuse longitudinal follow-up.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seattle Children's

Seattle, Washington, 98199, United States

RECRUITING

MeSH Terms

Conditions

Suicidal IdeationSuicide, Attempted

Condition Hierarchy (Ancestors)

SuicideSelf-Injurious BehaviorBehavioral SymptomsBehavior

Study Officials

  • Molly Adrian, Ph.D.

    University of Washington

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, Psychiatry and Behavioral Sciences

Study Record Dates

First Submitted

June 19, 2023

First Posted

August 18, 2023

Study Start

November 9, 2023

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

January 1, 2028

Last Updated

March 27, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will not share

Locations