MARRES
Prospective Cohort Study of Mastectomy With Reconstruction Including Robot Endoscopic Breast Surgery
Sponsor study identifier
observational
2,000
1 country
18
Study Start
April 8, 2020
Actual (reported)Primary Completion
June 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 7, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Robotic mastectomy and immediate reconstruction have been introduced in 2015. However, since robotic mastectomy is the latest surgical technique, there is a lack of studies prospectively comparing conventional mastectomy and immediate reconstruction with robotic mastectomy. For this reason, this study is designed to establish a single institution cohort study that prospectively collects patients undergoing mastectomy and reconstruction. This study was initially designed as a single institution study, however, currently, the study was extended to the multicenter study including 18 institutions over the country. Using the established prospective cohort data, a comparative study of robotic mastectomy with conventional mastectomy and reconstruction, and cost-effectiveness and satisfaction of robotic endoscopic surgery, and cost-effectiveness and satisfaction of reconstructive surgery are to be analyzed.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 7, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 8, 2020
Actual (reported)September 18, 2020
Actual (reported)October 14, 2020
Actual (reported)June 30, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 7, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Postoperative complication rates in 30 days
Postoperative complication rates are calculated as total number of postoperative complication cases per total operation cases.
Postoperative 30 days
Clavien-Dindo grade of postoperative complications
Clavien-Dindo grade of postoperative complications is evaluated. The highest grade of postoperative complications are used for the analysis.
Postoperative 180 days
Recurrence free survival (RFS)
Postoperative 5 years
Cases or Patients who underwent robotic nipple-sparing mastectomy and immediate reconstruction are enrolled in this arm. Robotic nipple-sparing mastectomy should be performed using robotic surgical systems. Robotic surgical systems include da Vinci S,Si, X, Xi, and SP systems. Axillary or lateral incisions are used for this procedure. Immediate reconstruction includes tissue expander insertion, direct-to-implant, latissimus dorsi flap, transverse abdominis rectus muscle flap, or deep inferior epigastric perforators flap. Cases with robotic mastectomy without immediate reconstruction are excluded.
Patients who underwent nipple-sparing mastectomy between 2020 and 2024 at Severance Hospital, Seoul, Korea
Kosin University Gospel Hospital
Busan, Busan, 49267, South Korea
Chungnam National University Sejong Hospital
Sejong, Chungcheongnam-do, 30099, South Korea
Kyungpook National University Chilgok Hospital
Daegu, Daegu, 41404, South Korea
Wonju Severance Christian hospital
Wŏnju, Gangwon-do, 26426, South Korea
Korea University Ansan Hospital
Ansan, Gyeonggi-do, 15355, South Korea
Myongji Hospital
Goyang-si, Gyeonggi-do, 10475, South Korea
Yongin Severance Hospital
Yongin-si, Gyeonggi-do, 16995, South Korea
Ryu JM, Lee J, Lee J, Ko B, Kim JH, Shin H, Park HS; Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG). Mastectomy with Reconstruction Including Robotic Endoscopic Surgery (MARRES): a prospective cohort study of the Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG) and Korean Breast Cancer Study Group (KBCSG). BMC Cancer. 2023 Jun 21;23(1):571. doi: 10.1186/s12885-023-10978-0.
Hyung Seok Park, MD, PhD
Severance Hospital
First Submitted
September 18, 2020
First Posted
October 14, 2020
Study Start
April 8, 2020
Actual (reported)Primary Completion
June 30, 2025
Estimated (date passed)Chemotherapy-induced Circadian Rhythm Disruption
Cancer incidence rate
Postoperative 5 years
Patient's satisfaction (about reconstruction expectations)
within preoperative 4 weeks to operation and within postoperative 6 month to 12 month.(Patients who have undergone skin sparing mastectomy can do within up to 3 years)
Patient's satisfaction (about reconstruction results)
within preoperative 4 weeks to operation and within postoperative 6 month to 12 month.(Patients who have undergone skin sparing mastectomy can do within up to 3 years)
Surgeon's satisfaction
Postoperative 6 month to 12 month(Patients who have undergone skin sparing mastectomy can do within up to 3 years
Cases or Patients who underwent conventional mastectomy and immediate reconstruction are enrolled in this arm. Conventional mastectomy should not be performed using robotic or endoscopic surgical systems. Any incisions can be performed for this procedure. Conventional mastectomy includes also Nipple-sparing mastectomy and Skin sparing mastectomy. Immediate reconstruction includes tissue expander insertion, direct-to-implant, latissimus dorsi flap, transverse abdominis rectus muscle flap, or deep inferior epigastric perforators flap. Cases without immediate reconstruction are excluded.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Samsung Changwon Medical Center
Changwon, Gyeongsangnam-do, 51353, South Korea
The Catholic University of Korea, Incheon ST. Mary's Hospital
Incheon, Incheon, 21431, South Korea
Korea University Anam Hospital
Seoul, Seoul, 02841, South Korea
Seoul National University Hospital
Seoul, Seoul, 03080, South Korea
Soonchunhyang University Hospital
Seoul, Seoul, 04401, South Korea
Gangnam Severance Hospital
Seoul, Seoul, 06273, South Korea
Seoul Metropolitan Government Seoul National University Boramae Medical Center
Seoul, Seoul, 07061, South Korea
Korea University Guro Hospital
Seoul, Seoul, 08308, South Korea
Yonsei University College of Medicine
Seoul, Seoul, 120-752, South Korea
Samsung Medical Center
Seoul, Seoul, 135-710, South Korea
Asan Medical Center
Seoul, Seoul, 138-736, South Korea
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 7, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
May 15, 2025
Record last verified: 2025-05
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Source: ClinicalTrials.gov.
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