QoL and Cognitive Function in Patients With Hypoparathyroidism

NCT04569604 | Completed

• 2 other identifiers: #111020181-10-72-304-18
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Hypoparathyroidism (HypoPT) is a disease with inadequate production of parathyroid hormone (PTH) from the parathyroid glands leading to hypocalcemia. The most common form is postsurgical HypoPT due to neck surgery resulting in removed or damaged parathyroid glands. HypoPT is a complex disease with a reduced Quality of life, mild cognitive impairment and in some patients have brain calcifications. The aim of the present study is to investigate the cognitive function in patients with postsurgical and non-surgical (HypoPT) by neuropsychological assessments and magnetic resonance imaging (MRI). The investigators will apply a contrast-enhanced MRI based method to HypoPT patients and age- and gender matched controls to examine whether capillary dysfunction can be detected, and whether symptom severity across patients correlates with the degree of capillary dysfunction in certain brain regions. To our knowledge there have been no previous studies on cognitive impairment and its origin in patients with HypoPT. The investigators hypothesize that the symptoms of HypoPT patients represent various degrees of capillary dysfunction, which interfere with their brain function.

Conditions

Hypoparathyroidism; Pseudo Hypoparathyroidism

Keywords

Quality of Life; MRI; Cognitive Impairment; Hypoparathyroidism; Pseudohypoparathyroidism

Outcome Measures

Primary Outcomes (1)

• Capillary transit time heterogeneity

  Capillary transit time heterogeneity is measured by MRI scans

  MRI scan performed at baseline, no follow-up up. It takes 1 hour to perform

Secondary Outcomes (8)

• Index 1: Processing speed

  Neuropsychological tests are performed immediately before or immediately after the MRI scan and scheduled to take 1½ hours.

• Index 2: Working memory

  Neuropsychological tests are performed immediately before or immediately after the MRI scan and scheduled to take 1½ hours.

• Index 3: Executive function

  Neuropsychological tests are performed immediately before or immediately after the MRI scan and scheduled to take 1½ hours.

• Index 4: Verbal learning and memory

  Neuropsychological tests are performed immediately before or immediately after the MRI scan and scheduled to take 1½ hours.

• Index 5: Visual learning and memory

  Neuropsychological tests are performed immediately before or immediately after the MRI scan and scheduled to take 1½ hours.

Study Arms (4)

Postsurgical hypoparathyroidism

Patients with hypoparathyroidism for 3 or more years after neck surgery

Diagnostic Test: MRI scans; Diagnostic Test: Neuro cognitive tests; Diagnostic Test: Questionnaires on Quality of Life; Diagnostic Test: Blood samples; Diagnostic Test: 24 hr urine samples

Non-surgical hypoparathyroidism

Patients with hypoparathyroidism for 3 or more years without neck surgery

Diagnostic Test: MRI scans; Diagnostic Test: Neuro cognitive tests; Diagnostic Test: Questionnaires on Quality of Life; Diagnostic Test: Blood samples; Diagnostic Test: 24 hr urine samples

Pseudohypoparathyroidism

Patients with the diagnosis of Pseudohypoparathyroidism

Diagnostic Test: MRI scans; Diagnostic Test: Neuro cognitive tests; Diagnostic Test: Questionnaires on Quality of Life; Diagnostic Test: Blood samples; Diagnostic Test: 24 hr urine samples

Healthy controls

25 controls from the background population matched on age (±3 years), gender and level of education with the 25 patients with postsurgical hypoparathyroidism

Diagnostic Test: MRI scans; Diagnostic Test: Neuro cognitive tests; Diagnostic Test: Questionnaires on Quality of Life; Diagnostic Test: Blood samples; Diagnostic Test: 24 hr urine samples

Interventions

MRI scans DIAGNOSTIC_TEST

Contrast-enhanced, magnetic resonance imaging (MRI) based method to detect disturbances in microvascular flow patterns in the human brain

Healthy controls; Non-surgical hypoparathyroidism; Postsurgical hypoparathyroidism; Pseudohypoparathyroidism

Neuro cognitive tests DIAGNOSTIC_TEST

Standard neuropsychological test battery consists of validated tests to assess cognitive domains including verbal and visual memory, attention, language, visuospatial and executive functioning.

Healthy controls; Non-surgical hypoparathyroidism; Postsurgical hypoparathyroidism; Pseudohypoparathyroidism

Questionnaires on Quality of Life DIAGNOSTIC_TEST

SF36v2, WHO-5 well-being index, HPQ28, Symptom questionnaire, and a general questionnaire on background information, medication and diet.

Healthy controls; Non-surgical hypoparathyroidism; Postsurgical hypoparathyroidism; Pseudohypoparathyroidism

Blood samples DIAGNOSTIC_TEST

Markers of calcium homeostasis, inflammatory markers and hematology.

Healthy controls; Non-surgical hypoparathyroidism; Postsurgical hypoparathyroidism; Pseudohypoparathyroidism

24 hr urine samples DIAGNOSTIC_TEST

24 hr urine content of calcium, phosphate, magnesium, and creatinine.

Healthy controls; Non-surgical hypoparathyroidism; Postsurgical hypoparathyroidism; Pseudohypoparathyroidism

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients with postsurgical, non-surgical and pseudo hypoparathyroidism will be invited from our outpatient clinic to participate in the study. The healthy controls will be randomly recruited from the background population by an extract from the CPR register and an invitation to participate in the study will be send by electronic letter.

You may qualify if:

• Patients:
• Male or female with age between 18 and 70 years.
• A low endogenous PTH production as verified by low plasma levels of intact PTH, necessitating treatment with 1-αhydroxylated vitamin D analogs.
• HypoPT for 3 years with continuous alphacalcidol or calcitriol treatment prior to study entry (except for the patients with PHP).
• In case of thyroid disease, TSH within reference range within the last year
• Speaks and reads Danish
• Controls:
• Male or female with age between 18 and 80 years.
• No known diseases in the calcium homeostasis
• Speaks and reads Danish

You may not qualify if:

• Reduced kidney function (eGFR \< 30 mL/min/1.73m2).
• Diabetes type 1 or 2
• History of hypertension for more than two years (treated or untreated)
• Clinical suspicion of major depression (also if treated)
• Clinical suspicion of alcohol-related dementia
• Other organic or psychiatric cause the patients symptoms
• Contraindications to contrast-enhanced MRI.
• Metal implants close to the head, which will interfere with the MRI or pacemaker. The patients will complete a metal scheme.
• Claustrophobia
• Unwillingness to participate

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (1)

Clinic for Osteoporosis, Aarhus University Hospital

Aarhus N, Jutland, 8200, Denmark

Location

Related Publications (56)

• Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res. 2013 Nov;28(11):2277-85. doi: 10.1002/jbmr.1979.

  PMID: 23661265 BACKGROUND

• Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study. J Bone Miner Res. 2015 Sep;30(9):1738-44. doi: 10.1002/jbmr.2501. Epub 2015 May 31.

  PMID: 25753591 BACKGROUND

• Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Pseudohypoparathyroidism - epidemiology, mortality and risk of complications. Clin Endocrinol (Oxf). 2016 Jun;84(6):904-11. doi: 10.1111/cen.12948. Epub 2015 Oct 19.

  PMID: 26387561 BACKGROUND

• Bohrer T, Krannich JH. Depression as a manifestation of latent chronic hypoparathyroidism. World J Biol Psychiatry. 2007;8(1):56-9. doi: 10.1080/15622970600995146.

  PMID: 17366354 BACKGROUND

• Lawlor BA. Hypocalcemia, hypoparathyroidism, and organic anxiety syndrome. J Clin Psychiatry. 1988 Aug;49(8):317-8.

  PMID: 3045102 BACKGROUND

• Snowdon JA, Macfie AC, Pearce JB. Hypocalcaemic myopathy with paranoid psychosis. J Neurol Neurosurg Psychiatry. 1976 Jan;39(1):48-52. doi: 10.1136/jnnp.39.1.48.

  PMID: 1255212 BACKGROUND

• Arlt W, Fremerey C, Callies F, Reincke M, Schneider P, Timmermann W, Allolio B. Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol. 2002 Feb;146(2):215-22. doi: 10.1530/eje.0.1460215.

  PMID: 11834431 BACKGROUND

• Astor MC, Lovas K, Debowska A, Eriksen EF, Evang JA, Fossum C, Fougner KJ, Holte SE, Lima K, Moe RB, Myhre AG, Kemp EH, Nedrebo BG, Svartberg J, Husebye ES. Epidemiology and Health-Related Quality of Life in Hypoparathyroidism in Norway. J Clin Endocrinol Metab. 2016 Aug;101(8):3045-53. doi: 10.1210/jc.2016-1477. Epub 2016 May 17.

  PMID: 27186861 BACKGROUND

• Sikjaer T, Moser E, Rolighed L, Underbjerg L, Bislev LS, Mosekilde L, Rejnmark L. Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism. J Bone Miner Res. 2016 Jul;31(7):1440-8. doi: 10.1002/jbmr.2812. Epub 2016 Mar 31.

  PMID: 26865527 BACKGROUND

• Sikjaer T, Rolighed L, Hess A, Fuglsang-Frederiksen A, Mosekilde L, Rejnmark L. Effects of PTH(1-84) therapy on muscle function and quality of life in hypoparathyroidism: results from a randomized controlled trial. Osteoporos Int. 2014 Jun;25(6):1717-26. doi: 10.1007/s00198-014-2677-6. Epub 2014 Apr 1.

  PMID: 24687385 BACKGROUND

• Velasco PJ, Manshadi M, Breen K, Lippmann S. Psychiatric aspects of parathyroid disease. Psychosomatics. 1999 Nov-Dec;40(6):486-90. doi: 10.1016/s0033-3182(99)71186-2.

  PMID: 10581976 BACKGROUND

• Underbjerg L, Sikjaer T, Rejnmark L. Health-related quality of life in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism. Clin Endocrinol (Oxf). 2018 Jun;88(6):838-847. doi: 10.1111/cen.13593. Epub 2018 Apr 3.

  PMID: 29520810 BACKGROUND

• Abiusi G, Dominguez RO, Parada Marcilla M, Lesyk S, Laguarde N, Yobstraibizer F. [Asymptomatic encephalic calcifications in postsurgical hypoparathyroidism]. Neurologia. 2009 Sep;24(7):454-6. Spanish.

  PMID: 19921554 BACKGROUND

• Basak RC. A case report of Basal Ganglia calcification - a rare finding of hypoparathyroidism. Oman Med J. 2009 Jul;24(3):220-2. doi: 10.5001/omj.2009.44.

  PMID: 22224190 BACKGROUND

• Bhimani S, Sarwar M, Virapongse C, Rojas R, Freilich M. Computed tomography of cerebrovascular calcifications in postsurgical hypoparathyroidism. J Comput Assist Tomogr. 1985 Jan-Feb;9(1):121-4. doi: 10.1097/00004728-198501000-00022.

  PMID: 3968258 BACKGROUND

• Chow KS, Lu DN. [Primary hypoparathyroidism with basal ganglia calcification: report of a case]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1989 Mar-Apr;30(2):129-33. Chinese.

  PMID: 2637591 BACKGROUND

• DANOWSKI TS, LASSER EC, WECHSLER RL. Calcification of basal ganglia in post-thyroidectomy hypoparathyroidism. Metabolism. 1960 Nov;9:1064-5. No abstract available.

  PMID: 13719679 BACKGROUND

• EATON, L. M. & HAINES, S. F. Parathyroid insuffiency with symmetrical cerebral calcification. Journal of the American Medical Association 113, 749-753 (1939).

  BACKGROUND

• Forman MB, Sandler MP, Danziger A, Kalk WJ. Basal ganglia calcification in postoperative hypoparathyroidism. Clin Endocrinol (Oxf). 1980 Apr;12(4):385-90. doi: 10.1111/j.1365-2265.1980.tb02725.x.

  PMID: 7379319 BACKGROUND

• Fukunaga M, Otsuka N, Ono S, Kajihara Y, Nishishita S, Nakano Y, Yamamoto I, Torizuka K, Morita R. Computed tomography of basal ganglia calcifications in pseudo- and idiopathic hypoparathyroidism. Radiat Med. 1987 Nov-Dec;5(6):187-90.

  PMID: 3452848 BACKGROUND

• Garcia Urra D, Barquero Jimenez MS, Varela de Seijas E, Rico Lenza H. [Calcification of the basal ganglia and hypoparathyroidism: Fahr disease. Study of a family]. Arch Neurobiol (Madr). 1990 Jan-Feb;53(1):18-22. Spanish.

  PMID: 2393337 BACKGROUND

• Goncalves Junior JC, Oliveira TS, Arantes HP, Goncalves FT, Fonseca AR, Jorge PT. [Cerebral calcifications due to hypoparathyroidism: considerations about cases diagnosed many years after partial thyroidectomy]. Arq Bras Endocrinol Metabol. 2006 Dec;50(6):1133-7. doi: 10.1590/s0004-27302006000600023. Portuguese.

  PMID: 17221123 BACKGROUND

• Jorens PG, Appel BJ, Hilte FA, Mahler C, De Deyn PP. Basal ganglia calcifications in postoperative hypoparathyroidism: a case with unusual characteristics. Acta Neurol Scand. 1991 Feb;83(2):137-40. doi: 10.1111/j.1600-0404.1991.tb04663.x.

  PMID: 1902012 BACKGROUND

• Jorgensen H, Vogt H. [Familial, idiopathic hypoparathyroidism with intracerebral calcifications and extrapyramidal symptoms]. Tidsskr Nor Laegeforen. 1977 May 30;97(15):771-4. No abstract available. Norwegian.

  PMID: 194354 BACKGROUND

• Karimi M, Rasekhi AR, Rasekh M, Nabavizadeh SA, Assadsangabi R, Amirhakimi GH. Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major. Eur J Radiol. 2009 Jun;70(3):481-4. doi: 10.1016/j.ejrad.2008.02.003. Epub 2008 Mar 25.

  PMID: 18367361 BACKGROUND

• Mahmoodi M, De Sanctis V, Karimi M. Diffuse intracerebral calcification in a beta-thalassaemia major patient with hypoparathyroidism: a case report. Pediatr Endocrinol Rev. 2011 Mar;8 Suppl 2:331-3.

  PMID: 21705988 BACKGROUND

• Kartin P, Zupevc M, Pogacnik T, Cerk M. Calcification of basal ganglia, postoperative hypoparathyroidism and extrapyramidal, cerebellar, pyramidal motor manifestations. J Neurol. 1982;227(3):171-6. doi: 10.1007/BF00313572.

  PMID: 6181225 BACKGROUND

• LEVIN P. Intracranial calcification associated with hypoparathyroidism. Bull N Y Acad Med. 1962 Sep;38(9):632-7. No abstract available.

  PMID: 14464573 BACKGROUND

• Polverosi R, Zambelli C, Sbeghen R. [Calcification of the basal nuclei in hypoparathyroidism. The computed and magnetic resonance tomographic aspects]. Radiol Med. 1994 Jan-Feb;87(1-2):12-5. Italian.

  PMID: 8128014 BACKGROUND

• Preusser M, Kitzwoegerer M, Budka H, Brugger S. Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology. 2007 Oct;27(5):453-6. doi: 10.1111/j.1440-1789.2007.00790.x.

  PMID: 18018479 BACKGROUND

• Rastogi R, Beauchamp NJ, Ladenson PW. Calcification of the basal ganglia in chronic hypoparathyroidism. J Clin Endocrinol Metab. 2003 Apr;88(4):1476-7. doi: 10.1210/jc.2002-021804. No abstract available.

  PMID: 12679425 BACKGROUND

• Stelmasiak Z, Tarach JS, Nowicka-Tarach BM, Mitosek-Szewczyk K, Drop A. Idiopathic hypoparathyroidism with intracranial calcifications and dominant skin manifestations. Med Sci Monit. 2000 Jan-Feb;6(1):145-50.

  PMID: 11208303 BACKGROUND

• Levine MA. Pseudohypoparathyroidism: from bedside to bench and back. J Bone Miner Res. 1999 Aug;14(8):1255-60. doi: 10.1359/jbmr.1999.14.8.1255. No abstract available.

  PMID: 10457257 BACKGROUND

• Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, Garcia Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Juppner H, Kamenicky P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Makitie O, Martin R, Martos-Moreno GA, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A. Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement. Nat Rev Endocrinol. 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0.

  PMID: 29959430 BACKGROUND

• Jespersen SN, Ostergaard L. The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism. J Cereb Blood Flow Metab. 2012 Feb;32(2):264-77. doi: 10.1038/jcbfm.2011.153. Epub 2011 Nov 2.

  PMID: 22044867 BACKGROUND

• Ostergaard L, Jespersen SN, Mouridsen K, Mikkelsen IK, Jonsdottir KY, Tietze A, Blicher JU, Aamand R, Hjort N, Iversen NK, Cai C, Hougaard KD, Simonsen CZ, Von Weitzel-Mudersbach P, Modrau B, Nagenthiraja K, Riisgaard Ribe L, Hansen MB, Bekke SL, Dahlman MG, Puig J, Pedraza S, Serena J, Cho TH, Siemonsen S, Thomalla G, Fiehler J, Nighoghossian N, Andersen G. The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model. J Cereb Blood Flow Metab. 2013 May;33(5):635-48. doi: 10.1038/jcbfm.2013.18. Epub 2013 Feb 27.

  PMID: 23443173 BACKGROUND

• Betsholtz C, Keller A. PDGF, pericytes and the pathogenesis of idiopathic basal ganglia calcification (IBGC). Brain Pathol. 2014 Jul;24(4):387-95. doi: 10.1111/bpa.12158.

  PMID: 24946076 BACKGROUND

• Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K, Johansson BR, Betsholtz C. Pericytes regulate the blood-brain barrier. Nature. 2010 Nov 25;468(7323):557-61. doi: 10.1038/nature09522. Epub 2010 Oct 13.

  PMID: 20944627 BACKGROUND

• Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005 Sep 16;97(6):512-23. doi: 10.1161/01.RES.0000182903.16652.d7.

  PMID: 16166562 BACKGROUND

• Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014 Apr 3;508(7494):55-60. doi: 10.1038/nature13165. Epub 2014 Mar 26.

  PMID: 24670647 BACKGROUND

• Funk JL, Wei H, Downey KJ, Yocum D, Benjamin JB, Carley W. Expression of PTHrP and its cognate receptor in the rheumatoid synovial microcirculation. Biochem Biophys Res Commun. 2002 Oct 4;297(4):890-7. doi: 10.1016/s0006-291x(02)02263-5.

  PMID: 12359237 BACKGROUND

• Mouridsen K, Hansen MB, Ostergaard L, Jespersen SN. Reliable estimation of capillary transit time distributions using DSC-MRI. J Cereb Blood Flow Metab. 2014 Sep;34(9):1511-21. doi: 10.1038/jcbfm.2014.111. Epub 2014 Jun 18.

  PMID: 24938401 BACKGROUND

• Mouridsen K, Friston K, Hjort N, Gyldensted L, Ostergaard L, Kiebel S. Bayesian estimation of cerebral perfusion using a physiological model of microvasculature. Neuroimage. 2006 Nov 1;33(2):570-9. doi: 10.1016/j.neuroimage.2006.06.015. Epub 2006 Sep 12.

  PMID: 16971140 BACKGROUND

• Ostergaard L, Jespersen SN, Engedahl T, Gutierrez Jimenez E, Ashkanian M, Hansen MB, Eskildsen S, Mouridsen K. Capillary dysfunction: its detection and causative role in dementias and stroke. Curr Neurol Neurosci Rep. 2015 Jun;15(6):37. doi: 10.1007/s11910-015-0557-x.

  PMID: 25956993 BACKGROUND

• Eskildsen SF, Gyldensted L, Nagenthiraja K, Nielsen RB, Hansen MB, Dalby RB, Frandsen J, Rodell A, Gyldensted C, Jespersen SN, Lund TE, Mouridsen K, Braendgaard H, Ostergaard L. Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study. Neurobiol Aging. 2017 Feb;50:107-118. doi: 10.1016/j.neurobiolaging.2016.11.004. Epub 2016 Nov 19.

  PMID: 27951412 BACKGROUND

• Nielsen RB, Egefjord L, Angleys H, Mouridsen K, Gejl M, Moller A, Brock B, Braendgaard H, Gottrup H, Rungby J, Eskildsen SF, Ostergaard L. Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease. Alzheimers Dement. 2017 Oct;13(10):1143-1153. doi: 10.1016/j.jalz.2017.02.007. Epub 2017 Mar 23.

  PMID: 28343848 BACKGROUND

• Mouridsen K, Christensen S, Gyldensted L, Ostergaard L. Automatic selection of arterial input function using cluster analysis. Magn Reson Med. 2006 Mar;55(3):524-31. doi: 10.1002/mrm.20759.

  PMID: 16453314 BACKGROUND

• Hansen B, Khan AR, Shemesh N, Lund TE, Sangill R, Eskildsen SF, Ostergaard L, Jespersen SN. White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging. NMR Biomed. 2017 Sep;30(9):10.1002/nbm.3741. doi: 10.1002/nbm.3741. Epub 2017 May 22.

  PMID: 28543843 BACKGROUND

• Hansen B, Lund TE, Sangill R, Jespersen SN. Experimentally and computationally fast method for estimation of a mean kurtosis. Magn Reson Med. 2013 Jun;69(6):1754-60. doi: 10.1002/mrm.24743. Epub 2013 Apr 15.

  PMID: 23589312 BACKGROUND

• Hansen B, Shemesh N, Jespersen SN. Fast imaging of mean, axial and radial diffusion kurtosis. Neuroimage. 2016 Nov 15;142:381-393. doi: 10.1016/j.neuroimage.2016.08.022. Epub 2016 Aug 15.

  PMID: 27539807 BACKGROUND

• Lewis, M. et al. Assessment of cognition in an adolescent Indigenous population. Australian Psychologist 45, 123-131, doi:10.1080/00050060903352998 (2010).

  BACKGROUND

• Reitan, R. M. Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills 8 (1958).

  BACKGROUND

• Wechsler, D. Wechsler Adult Intelligence Scale. Third edn, (The Psychological Corporation, 1997).

  BACKGROUND

• Meyers, J. E. & Meyers, K. R. Rey Complex Figure Test and Recognition Trail. (Psychological Assessment Resources, 1995).

  BACKGROUND

• Nielsen H, Knudsen L, Daugbjerg O. Normative data for eight neuropsychological tests based on a Danish sample. Scand J Psychol. 1989;30(1):37-45. doi: 10.1111/j.1467-9450.1989.tb01066.x.

  PMID: 2740854 BACKGROUND

• Wilde D, Wilken L, Stamm B, Blaschke M, Heppner C, Chavanon ML, Leha A, Herrmann-Lingen C, Siggelkow H. The HPQ-Development and First Administration of a Questionnaire for Hypoparathyroid Patients. JBMR Plus. 2019 Nov 7;4(1):e10245. doi: 10.1002/jbm4.10245. eCollection 2020 Jan.

  PMID: 31956849 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma, serum and 24hr urine samples

MeSH Terms

Conditions

Hypoparathyroidism; Pseudohypoparathyroidism; Cognitive Dysfunction

Interventions

Magnetic Resonance Imaging; Blood Specimen Collection

Condition Hierarchy (Ancestors)

Parathyroid Diseases; Endocrine System Diseases; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metal Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Metabolic Diseases; Nutritional and Metabolic Diseases; Calcium Metabolism Disorders; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Clinical Laboratory Techniques; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Tanja T Sikjær, MD, PhD

  Department of Endocrinology and Internal Medicine, Aarhus University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, MD, PhD

Study Record Dates

• First Submitted: September 2, 2019
• First Posted: September 30, 2020
• Study Start: October 1, 2019
• Primary Completion: October 1, 2020
• Study Completion: December 1, 2021
• Last Updated: December 23, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)