NCT04564807

Brief Summary

The objective of this trial is to determine the effectiveness of an electronic cognitive behavioral therapy for insomnia (e-CBT-I) module in improving sleep and reducing alcohol use among heavy drinkers with insomnia. Specifically, it will test the effectiveness of Sleep Healthy Using the Internet (SHUTi), a well-validated version of e-CBT-I comprised of 6 weekly educational modules and daily sleep diaries. The rationale for this mixed methods proposal is that effective, nonpharmacologic treatments are necessary to stem the highly comorbid public health problems of alcohol use disorder (AUD) and insomnia. If successful, SHUTi will represent a novel and easily accessible intervention for reducing alcohol intake among high-risk heavy drinkers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
71

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 22, 2020

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 25, 2020

Completed
Same day until next milestone

Study Start

First participant enrolled

September 25, 2020

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2022

Completed
Last Updated

October 25, 2022

Status Verified

October 1, 2022

Enrollment Period

1.7 years

First QC Date

September 22, 2020

Last Update Submit

October 24, 2022

Conditions

Keywords

sleepcognitive behavioral therapyCBTelectronicalcoholnon-pharmacological

Outcome Measures

Primary Outcomes (3)

  • Change in Alcohol Use

    Alcohol use will be measured using the Timeline Follow Back (TLFB) calendar. Participants will report their drinking over the past 30 days.

    12 months (at baseline, 9 weeks, 3 months post-intervention, and 6 months post-intervention)

  • Change in Insomnia

    Insomnia will be measured using the Insomnia Severity Index (ISI). This survey has 7 questions related to insomnia. Scores range from 0-28, with higher scores indicating increased insomnia.

    12 months (at baseline, 9 weeks, 3 months post-intervention, and 6 months post-intervention)

  • Change in Sleep Quality

    Sleep quality will be assessed using the Pittsburgh Sleep Quality Index (PSQI). It measures seven areas (components): subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. Scores range from 0-indefinite. A score greater than 5 is indicative of poor sleep quality.

    12 months (at baseline, 9 weeks, 3 months post-intervention, and 6 months post-intervention)

Study Arms (2)

Web-Based Insomnia Education Program

ACTIVE COMPARATOR

Adult heavy drinkers with insomnia.

Behavioral: Web-Based Insomnia Education Program

SHUTi Intervention

EXPERIMENTAL

Adult heavy drinkers with insomnia.

Behavioral: SHUTi Intervention

Interventions

Participants will be given access to a web-based program on sleep education to read at their own pace during the 9-week intervention period. The program content overlaps with SHUTi on the following topics: insomnia symptoms, impacts, and causes, basic sleep improvement strategies, and when to see a doctor. The information is akin to that found on WebMD or National Sleep Foundation website. Unlike the SHUTi program, the information is fixed, accessible immediately (no week-to-week information "unlocking") and there are no customized bedtime or wake-time suggestions based on sleep diary data.

Web-Based Insomnia Education Program

Sleep Healthy Using the Internet (SHUTi) is a well-validated version of e-CBT-I comprised of 6 weekly educational modules and daily sleep diaries. Participants will have 9 weeks to complete 6 once-weekly educational "cores." Cores consist of: insomnia overview, sleep restriction, stimulus control, cognitive restructuring, sleep hygiene, and relapse prevention, and last approximately 45 minutes each. Participants will receive weekly objectives, as well as review and feedback on the previous core's assignments and sleep diary data, new material, assignments, and a summary. These features are supplemented with interactive features (i.e., personalized goal-setting, video vignettes). Participants receive daily emails prompting them to complete the 11-item sleep and alcohol use diary daily during the intervention.

SHUTi Intervention

Eligibility Criteria

Age21 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • engage in weekly alcohol binge episodes
  • moderate to severe insomnia

You may not qualify if:

  • history of severe alcohol or other substance use disorder
  • obstructive sleep apnea
  • schizophrenia
  • bipolar disorder
  • psychotic spectrum disorder
  • lack of internet access
  • lack of English fluency
  • pregnant or nursing

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Of Kentucky Psychology Research Lab

Lexington, Kentucky, 40504, United States

Location

MeSH Terms

Conditions

AlcoholismSleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Alcohol-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental DisordersSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System Diseases

Study Officials

  • Jessica Weafer, PhD

    University of Kentucky

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

September 22, 2020

First Posted

September 25, 2020

Study Start

September 25, 2020

Primary Completion

May 31, 2022

Study Completion

May 31, 2022

Last Updated

October 25, 2022

Record last verified: 2022-10

Data Sharing

IPD Sharing
Will not share

Locations