FHALL
The Effects of Higher- And Lower-Load Resistance Exercise Training on Leg and Arm Skeletal Muscle Mass in Healthy Young Adult Females
Sponsor study identifier
interventional
16
1 country
1
Study Start
January 5, 2021
Actual (reported)Primary Completion
August 12, 2021
Actual (reported)Study Completion
August 12, 2021
Actual (reported)When you perform weightlifting, your body makes new proteins within your muscle. These new proteins can increase the size of the fibers within your muscle to make your muscle larger, a process called hypertrophy. The common convention surrounding gains in muscle mass and strength are that higher-loads (i.e. heavier weights) used for fewer repetitions are better for increasing strength and lower-loads (i.e. lighter weights) used for higher repetitions are better for increasing muscle mass. However, recent research has found that when higher- and lower-loads are used when participants exercise until volitional fatigue (i.e. cannot perform another repetition), muscle mass and strength increases are similar regardless of using a higher- or lower-load. Many of these studies have examined this effect in males with fewer studies examining the effects of higher- and lower-load training in females when assessing changes in muscle mass, strength, and muscle endurance. Further, it has been shown that there is substantial individual variation in response to resistance exercise training where individuals can be broadly categorized as higher- or lower-responders to resistance exercise training. This study aims to explore how the muscle mass, strength, and muscle endurance of females are impacted by both higher- and lower-loads while also exploring how individuals may respond to the training interventions.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 12, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 4, 2020
Actual (reported)September 14, 2020
Actual (reported)January 5, 2021
Actual (reported)August 12, 2021
Actual (reported)August 12, 2021
Actual (reported)Change in upper- and lower-body skeletal muscle mass between weeks 1 and 12
The total skeletal muscle mass measured in each individual arm and leg quantified using dual-energy x-ray absorptiometry scanning
Weeks 1 and 12
Change in unilateral dumbbell bicep preacher curl one repetition maximum between weeks 1 and 12
Weeks 1 and 12
Change in unilateral knee extension one repetition maximum between weeks 1 and 12
Weeks 1 and 12
Change in unilateral dumbbell bicep preacher curl relative muscle endurance between weeks 1 and 12
Weeks 1 and 12
Change in unilateral dumbbell bicep preacher curl absolute muscle endurance between weeks 1 and 12
Weeks 1 and 12
Change in unilateral knee extension relative muscle endurance between weeks 1 and 12
Weeks 1 and 12
This treatment arm will have participants performing resistance training with loads of \~80% of an individuals one-repetition maximum. Each participant will have one arm and one leg assigned to this condition.
This treatment arm will have participants performing resistance training with loads of \~30% of an individuals one-repetition maximum. Each participant will have one arm and one leg assigned to this condition.
This intervention will have one arm and one leg of each participant training with \~80% of their one repetition maximum
This intervention will have one arm and one leg of each participant training with \~30% of their one repetition maximum
The University of British Columbia
Vancouver, British Columbia, V6T 1Z3, Canada
Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002 Nov;88(1-2):50-60. doi: 10.1007/s00421-002-0681-6. Epub 2002 Aug 15.
Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW. Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-analysis. J Strength Cond Res. 2017 Dec;31(12):3508-3523. doi: 10.1519/JSC.0000000000002200.
Cameron J Mitchell, PhD
University of British Columbia
16 participants (actual enrollment reported by the registry).
First Submitted
September 4, 2020
First Posted
September 14, 2020
Study Start
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Mitchell CJ, Churchward-Venne TA, West DW, Burd NA, Breen L, Baker SK, Phillips SM. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol (1985). 2012 Jul;113(1):71-7. doi: 10.1152/japplphysiol.00307.2012. Epub 2012 Apr 19.
Roberts BM, Nuckols G, Krieger JW. Sex Differences in Resistance Training: A Systematic Review and Meta-Analysis. J Strength Cond Res. 2020 May;34(5):1448-1460. doi: 10.1519/JSC.0000000000003521.
Franco CMC, Carneiro MADS, Alves LTH, Junior GNO, de Sousa JFR, Orsatti FL. Lower-Load is More Effective Than Higher-Load Resistance Training in Increasing Muscle Mass in Young Women. J Strength Cond Res. 2019 Jul;33 Suppl 1:S152-S158. doi: 10.1519/JSC.0000000000002970.
Fliss MD, Stevenson J, Mardan-Dezfouli S, Li DCW, Mitchell CJ. Higher- and lower-load resistance exercise training induce load-specific local muscle endurance changes in young women: a randomised trial. Appl Physiol Nutr Metab. 2022 Dec 1;47(12):1143-1159. doi: 10.1139/apnm-2022-0263. Epub 2022 Aug 26.
January 5, 2021
Actual (reported)Primary Completion
August 12, 2021
Actual (reported)Study Completion
August 12, 2021
Actual (reported)Last Updated
September 29, 2021
Record last verified: 2021-09
A plan has not yet been made to make individual participant data available to other researchers
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Source: ClinicalTrials.gov.
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