Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease

NCT04541498 | Completed

• 1 other identifier: UMB-KKI-103
• Study Type: observational
• Target: 150,000
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the fact that the topic of air pollution has been in focus of researchers for many years, there are no big studies that take up the matter of its influence on acute coronary, cerebral syndromes and CVD mortality in Europe. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution on cardiovascular diseases and CVD mortality in Poland.

Conditions

Pollution; Exposure; Acute Coronary Syndrome; Chronic Coronary Insufficiency; Particulate Matter Inhalation Injury; Cardiovascular Diseases; Cardiovascular Risk Factor

Keywords

Air pollution; Particulate Matter; Acute Coronary Syndromes; Cardiovascular Disease; Risk factors

Outcome Measures

Primary Outcomes (3)

• Incidence of acute coronary syndromes

  Number of acute coronary syndromes related with impact of air pollution

  Through study completion, an average of 1 year

• Incidence of cardiovascular mortality

  Number of cardiovascular deaths related with impact of air pollution

  Through study completion, an average of 1 year

• Incidence of acute cerebral syndromes

  Number of acute cerebral syndromes related with impact of air pollution

  Through study completion, an average of 1 year

Study Arms (2)

Population of Poland

Exposure to short term long term effects of air pollution and climate change

Other: Impact of air pollution and climate changes

Patients with Acute Coronary and Cerebral Syndromes

Exposure to short term long term effects of air pollution and climate change

Other: Impact of air pollution and climate changes

Interventions

Impact of air pollution and climate changes OTHER

To assess the short- and long- term impact of air pollution and climate changes

Patients with Acute Coronary and Cerebral Syndromes; Population of Poland

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In primary we focus on Podlaskie Voivodeship. The region is located in north-east Poland which is a developing country as well as one of the poorest regions of the EU. Within four national parks, the region is widely known as the Green Lungs of Poland, mainly due to large areas covered by forests, lack of factories, and relatively low industrialization.

You may qualify if:

• \- residents from analysed area.

You may not qualify if:

• \- none

Sponsors & Collaborators

• Medical University of Bialystok: lead

Study Sites (1)

Department of Invasive Cardiology Medical University of Białystok 24A M. Skłodowskiej-Curie St.

Bialystok, 15-276, Poland

Location

Related Publications (5)

• Kuzma L, Pogorzelski S, Struniawski K, Dobrzycki S, Bachorzewska-Gajewska H. Effect of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients. Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15064. Epub 2019 Nov 19.

  PMID: 31742576 RESULT

• Kuzma L, Pogorzelski S, Struniawski K, Bachorzewska-Gajewska H, Dobrzycki S. Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry). Int J Hyg Environ Health. 2020 Aug;229:113578. doi: 10.1016/j.ijheh.2020.113578. Epub 2020 Aug 3.

  PMID: 32758862 RESULT

• Kuzma L, Struniawski K, Pogorzelski S, Bachorzewska-Gajewska H, Dobrzycki S. Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Follow-Up. J Clin Med. 2020 Jul 23;9(8):2351. doi: 10.3390/jcm9082351.

  PMID: 32717977 RESULT

• Kuzma L, Wanha W, Kralisz P, Kazmierski M, Bachorzewska-Gajewska H, Wojakowski W, Dobrzycki S. Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS - Air Pollution Study). Environ Res. 2021 Jun;197:111154. doi: 10.1016/j.envres.2021.111154. Epub 2021 Apr 17.

  PMID: 33872649 RESULT

• Rogalska E, Kurasz A, Kuzma L, Bachorzewska-Gajewska H, Dobrzycki S, Kozinski M, Sobkowicz B, Tomaszuk-Kazberuk A. Comparing Atrial-Fibrillation Validated Rapid Scoring Systems in the Long-Term Mortality Prediction in Patients Referred for Elective Coronary Angiography: A Subanalysis of the Bialystok Coronary Project. Int J Environ Res Public Health. 2022 Aug 21;19(16):10419. doi: 10.3390/ijerph191610419.

  PMID: 36012052 DERIVED

MeSH Terms

Conditions

Acute Coronary Syndrome; Cardiovascular Diseases

Interventions

Climate Change

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Climatic Processes; Ecological and Environmental Phenomena; Biological Phenomena

Study Officials

• Lukasz Kuzma, MD, PhD

  Medical University of Bialystok, Department of Invasive Cardiology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: August 21, 2020
• First Posted: September 9, 2020
• Study Start: January 1, 2019
• Primary Completion: August 1, 2021
• Study Completion: January 1, 2022
• Last Updated: January 10, 2022

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)