Impact of Anesthetic Environment the Sex Ratio of the Children of Female Assistants

NCT04532502 | Completed

• 1 other identifier: GENREANES
• Study Type: observational
• Target: 143
• Locations: 1 country
• Sites: 1

Brief Summary

The aims of this multi center retrospective study was to determine:

• whether the sex ratio of the offspring of female assistants in anesthesia-resuscitation differs from that of the population at large
• whether the assistants' work environment at the time of their offspring's conception influences the sex of their offspring

Conditions

Anesthesia, General; Anesthetics Adverse Reaction

Keywords

Anesthesia care providers; offspring sex ratio; Inhalation induction of anesthesia

Outcome Measures

Primary Outcomes (1)

• Offspring sex ratio

  Offspring sex ratio of female anesthesia assistants will be recorded

  5 years (duration of anesthesia training)

Study Arms (1)

Study group

All female assistants in anesthesia

Drug: Anesthetics, Inhalation

Interventions

Anesthetics, Inhalation DRUG

Work environmental exposure

Study group

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The anesthesia department of the three French-speaking universities in Belgium wimp e-mail a questionnaire to all female assistants in anesthesia-resuscitation via a system similar to Survey Monkey. The data will be completely anonymized through those of such a system. Reminder will be e-mailed 1 and 3 months after the questionnaire is sent out. Filling the questionnaire will be equated with consent

You may qualify if:

• Female assistants in anesthesia-resuscitation in the Wallonia-Brussels Federation (Belgium) who conceived one or more children in the course of their training between 2009 and 2019 and who delivered before the end of 2019 (cut-off: midnight on 31 December 2019)

You may not qualify if:

• Male assistants in anesthesia-resuscitation
• Female assistants in anesthesia-resuscitation who trained before 2009 or after 2019.
• Female assistants in anesthesia-resuscitation who relied on medically assisted reproduction.

Sponsors & Collaborators

• University of Liege: lead

Study Sites (1)

ULiege

Liège, 4000, Belgium

Location

Related Publications (2)

• Gupta D, Kaminski E, McKelvey G, Wang H. Firstborn offspring sex ratio is skewed towards female offspring in anesthesia care providers: A questionnaire-based nationwide study from United States. J Anaesthesiol Clin Pharmacol. 2013 Apr;29(2):221-7. doi: 10.4103/0970-9185.111728.

  PMID: 23878446 BACKGROUND

• Leroy C, Daelemans C, Debauche C, Van Leeuw V. Santé périnatale en Wallonie - année 2017, Centre d'Epidémiologie Périnatale 2019.

  BACKGROUND

MeSH Terms

Interventions

Anesthetics, Inhalation

Intervention Hierarchy (Ancestors)

Anesthetics, General; Anesthetics; Central Nervous System Depressants; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Central Nervous System Agents; Therapeutic Uses

Study Officials

• Philippe J Van der Linden, MD

  CHU Brugmann, Free University of Brussels, Belgium

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 25, 2020
• First Posted: August 31, 2020
• Study Start: October 2, 2021
• Primary Completion: December 2, 2021
• Study Completion: December 2, 2021
• Last Updated: December 3, 2021

Record last verified: 2021-12

Locations

BE (1)