NCT04530760|Recruiting
Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation
ATOMIC
Impact of Intraabdominal Hypertension on Microaspiration Incidence in Cirrhotic Patients
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ATOMIC
Impact of Intraabdominal Hypertension on Microaspiration Incidence in Cirrhotic Patients
Sponsor study identifier
Secondary identifiers
OTHER · ID-RCB number,ANSM
observational
226
1 country
2
Study Start
October 8, 2021
Actual (reported)Primary Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 27, 2020
Actual (reported)August 28, 2020
Actual (reported)October 8, 2021
Actual (reported)December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
abundant microaspiration
presence of pepsin or alpha amylase at significant level in at least 30% of tracheal aspirates
48 hours after inclusion
Mortality
from ICU admission until day 28
Incidence of ventilator associated pneumonia (VAP)
from intubation until day 28 or extubation
duration of mechanical ventilation
from intubation until day 28 or extubation
incidence of patients requiring renal replacement therapy
from ICU admission until Day 28 or ICu discharge, whichever came first
incidence of cirrhosis related complications
from ICU admission until Day 28 or ICU discharge, whichever came first
patients with intraabdominal hypertension defined as intravesical pressure more than 12 mmHg
patients with no intraabdominal hypertension
cirrhotic patients receiving invasive mechanical ventilation
Hop Claude Huriez Chu Lille
Lille, 59037, France
Hop Salengro - Hopital B
Lille, 59037, France
Saad Nseir, MD,PhD
University Hospital, Lille
First Submitted
April 27, 2020
First Posted
August 28, 2020
Study Start
October 8, 2021
Actual (reported)Primary Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Pupillometry and Nociception Level Index for the Evaluation of Pain in Intensive Care Unit.
Contact the study team to confirm eligibility.
Study Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
December 23, 2025
Record last verified: 2025-12
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Source: ClinicalTrials.gov.
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