Comparison of Three Motor-cognitive Training Programs

NCT04504643 | Completed

• 1 other identifier: 2019-A03263-54
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Understanding how to delay age-related physical and mental declines is an issue for aging research. It has been shown that isolated aerobic, coordination and cognitive training improve brain functions and cognitive performances. Moreover, the combination of them leads to greater effects. Different combination modalities are possible: training programs demanding cognitive resources within the activity performed in a natural environment like Nordic Walking (or Tai chi, Dance...); or as in a conceptually-grounded circuit training where training components are systematically combined and their intensity controlled. The aim of this study is to compare three training programs: a Nordic walking one (NW), and two conceptual grounded, circuits training (CT-c; CT-fit). CT-c implemented by dual-task (DT) exercises, while CT-fit characterized by cognitive charge embodied in the movements through the use of technology. An improvement in physical, motor, and cognitive functions is expected by all three groups. However, our primary hypothesis is that the CT-fit will impact executive functions more. 45 healthy independent living community dwellers participants aged 65 to 80 will be recruited. Participants will be included after a general medical examination (geriatric screening and cycle-ergometer maximal effort test). The main exclusion criteria are signs of cognitive impairment, (MMSE \<26/30), and physical impairments. Participants will be randomly divided into the 3 groups (NW, CT-c, CT-fit): The training program will last 8 weeks, 1 hour 3 times a week. Pre and post-tests will include cognitive assessment (MoCA; TMT; Stroop task, Happy Neuron™ working memory test, Rey Complex Figure copy task and dual-task capacities through the DT-OTMT); motor fitness assessment (Bipedal upright standing, Unipedal balance test, walking speed and size of the base of support, Timed Up \& Go, Chair sit and reach test and Four square stepping test) and physical assessment (10 m incremental shuttle walking test, maximal handgrip force, 30s chair rise stand). Improving cognitive functions by adding new technology embodied in a systematically combined training (exergame), would result to be the best solution to optimize training for aging people.

Conditions

Cognitive Decline

Keywords

aging, cognition, cognitive-motor training, Nordic walking

Outcome Measures

Primary Outcomes (6)

• Changes in working memory function through HappyNeuron Software

  Assessment for changing in working memory function tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

• Changes in inhibition processes through Stroop task test

  Assessment for changing of inhibition processes tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

• Changes in switching capacities through Trial Making Test part A and part B (TMT-A and TMT-B)

  Assessment for changing of switching capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

• Changes in visuospatial capacities through Rey complex Figure copy task

  Assessment for changing of visuospatial capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

• Changes in dual task capacities through Walking Oral Trail Making Test part A and part B (OTMT-A and OTMT-B)

  Assessment for chainging for dual task capacities tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

• Changes in global cognition capacity through the Moca test

  Assessment for changing for general cognition tested within the 4 weeks before the intervention (8 weeks of duration) and within the 4 weeks after the intervention ended. Up to 5 months for the results analysis and manuscript writing.

  Through study completion, an average of 9 months

Secondary Outcomes (7)

• Changes in balance capacities through Bipedal upright standing and Unipedal leg stance tests

  Through study completion, an average of 9 months

• Changes in Gait pattern assessment

  Through study completion, an average of 9 months

• Changes in functional mobility through the Timed Up & Go test

  Through study completion, an average of 9 months

• Changes for flexibility through the Chair-sit and reach test

  Through study completion, an average of 9 months

• Changes in motor coordination through the Four- Square Stepping test

  Through study completion, an average of 9 months

Study Arms (3)

Technology-assisted circuit training

EXPERIMENTAL

Multicomponent circuit training using FItLight Trainer™ as an embodied tool to perform motor task. The circuit training is composed by aerobic, muscular, coordination and balance exercises.

Other: Technology-assisted circuit training

Conventional circuit training

EXPERIMENTAL

Multicomponent circuit training composed by aerobic, muscular, balance and coordination exercises. Coordination exercises wll be charged of simple dual task cognitive exercises (counting backwards, or making some easy math calculations, repeating words backward, finding words of the same family).

Other: Conventional circuit training

Nordic Walking

EXPERIMENTAL

The training sessions are performed in a natural parc, which offers pathways of different lengths and levels of difficulty that will increase over the weeks.

Other: Nordic walking

Interventions

Technology-assisted circuit training OTHER

Circuit training assisted by Fitlight™ 3 times a week for one hour during 8 weeks

Technology-assisted circuit training

Conventional circuit training OTHER

Conventional circuit training including single and dual task 3 times a week for one hour during 8 weeks

Conventional circuit training

Nordic walking OTHER

Classic nordic walking 3 times a week for one hour during 8 weeks

Nordic Walking

Eligibility Criteria

• Age: 65 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Considered apt for moderate physical activity practice (validated by a maximal VO2 cycle-ergometer test by a cardiologist)
• Sedentary or moderately active (objectified by the categories obtained at the IPAQ)
• Cognitively healthy (objectified by a score at the MMSE of 26 and above)

You may not qualify if:

• Colorblindness
• Uncorrected earing and/or visual impairment
• Presence of a known psychiatric or neurologic condition
• Under psychotropic treatment or beta-blockers

Sponsors & Collaborators

• Aix Marseille Université: lead

Study Sites (1)

Institut des Sciences du Mouvement Etienne-Jules Marey (UMR 7287)

Marseille, France

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Nordic Walking

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Walking; Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise; Motor Activity

Study Officials

• Jean-Jacques Temprado, Ph.D.

  Aix Marseille Université

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 2, 2020
• First Posted: August 7, 2020
• Study Start: October 1, 2022
• Primary Completion: April 30, 2023
• Study Completion: April 30, 2023
• Last Updated: February 16, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)