NCT05016336

Brief Summary

Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive functioning for older adults. Furthermore, accumulative evidence suggests that strategy-based cognitive training may also improve the trainee's memory. In this study, the investigators examined the effects of a combined strategy-based cognitive training and a socially interactive learning method on cognitive performance and transfer effects in older adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2018

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 18, 2018

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 3, 2019

Completed
21 days until next milestone

Study Completion

Last participant's last visit for all outcomes

February 24, 2019

Completed
2.5 years until next milestone

First Submitted

Initial submission to the registry

August 17, 2021

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 23, 2021

Completed
Last Updated

August 26, 2021

Status Verified

August 1, 2021

Enrollment Period

3 months

First QC Date

August 17, 2021

Last Update Submit

August 21, 2021

Conditions

Keywords

Cognitive trainingStrategy trainingOlder adultsMnemonicSocial interaction

Outcome Measures

Primary Outcomes (1)

  • Verbal Fluency Test (Chiu et al., 1997)

    Participants were asked to say aloud as many words as possible belonging to a given category (animal's category and fruit and vegetables category) within a period of sixty seconds.

    Change from baseline (before treatment) to immediately after treatment (12 weeks)

Secondary Outcomes (3)

  • Wechsler Digit Span Test (Wechsler 2008)

    Change from baseline (before treatment) to immediately after treatment (12 weeks)

  • Words Recall Test (Fairchild et al., 2013)

    Change from baseline (before treatment) to immediately after treatment (12 weeks)

  • Corsi Block-Tapping Test (Corsi 1972)

    Change from baseline (before treatment) to immediately after treatment (12 weeks)

Study Arms (2)

strategy-based cognitive training + social interaction

EXPERIMENTAL

The experimental group received twelve 60 minutes sessions of strategy-based cognitive training. (i.e., training in mnemonic memory strategies). We chose to train multiple strategies instead of a single one in effort to reach larger training gains. each session began with engaging conversations between the researcher and participants. After each practice trial, participants were encouraged to share their ideas/stories/associations or visual images (mnemonic uses) in turn. All other participants were allowed to give feedback relating to what can be learned from each mnemonic use or give their own ideas on how they think it can be improved.

Other: Social interaction combined with cognitive training based on mnemonic strategies.

social interaction

ACTIVE COMPARATOR

The social interaction control group received the same number of group meetings but without the strategy training. Meetings content consisted of providing tools for making social connections, providing tools for interpersonal communication and raising the participant's sense of personal well-being through group contact.

Other: Social interaction group

Interventions

In the first six sessions, participants in the experimental group learned and practiced six different mnemonic strategies: Story-Formation strategy, Face-Name strategy, Peg-Word strategy, Chunking strategy, Key-Word strategy and the Method of Loci. In the following six sessions, in order to assimilate the strategies they learned, participants practiced the same tasks.

strategy-based cognitive training + social interaction

In the control group, each session also began with a conversation between the participants. The sessions then dealt with the content of interpersonal communication and the acquisition of tools for creating interpersonal relationships. Participants were asked to share the way they used the tools they acquired between sessions and received feedback from the other participants

social interaction

Eligibility Criteria

Age64 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy participants who are active in a designated group in the community.

You may not qualify if:

  • Any diagnosis of cognitive decline.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Bar Ilan University

Ramat Gan, 5290002, Israel

Location

Related Publications (18)

  • Choi M. Association between social participation and cognitive function among community-dwelling older adults living alone: Analysis of a nationally representative survey. Int J Nurs Pract. 2020 Aug;26(4):e12841. doi: 10.1111/ijn.12841. Epub 2020 May 27.

  • Hikichi H, Kondo K, Takeda T, Kawachi I. Social interaction and cognitive decline: Results of a 7-year community intervention. Alzheimers Dement (N Y). 2016 Dec 21;3(1):23-32. doi: 10.1016/j.trci.2016.11.003. eCollection 2017 Jan.

  • Krueger KR, Wilson RS, Kamenetsky JM, Barnes LL, Bienias JL, Bennett DA. Social engagement and cognitive function in old age. Exp Aging Res. 2009 Jan-Mar;35(1):45-60. doi: 10.1080/03610730802545028.

  • Park DC, Gutchess AH, Meade ML, Stine-Morrow EA. Improving cognitive function in older adults: nontraditional approaches. J Gerontol B Psychol Sci Soc Sci. 2007 Jun;62 Spec No 1:45-52. doi: 10.1093/geronb/62.special_issue_1.45.

  • Chan MY, Haber S, Drew LM, Park DC. Training Older Adults to Use Tablet Computers: Does It Enhance Cognitive Function? Gerontologist. 2016 Jun;56(3):475-84. doi: 10.1093/geront/gnu057. Epub 2014 Jun 13.

  • Iizuka A, Suzuki H, Ogawa S, Kobayashi-Cuya KE, Kobayashi M, Inagaki H, Sugiyama M, Awata S, Takebayashi T, Fujiwara Y. Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game. Int J Geriatr Psychiatry. 2019 Feb;34(2):324-332. doi: 10.1002/gps.5024. Epub 2018 Dec 10.

  • Myhre JW, Mehl MR, Glisky EL. Cognitive Benefits of Online Social Networking for Healthy Older Adults. J Gerontol B Psychol Sci Soc Sci. 2017 Sep 1;72(5):752-760. doi: 10.1093/geronb/gbw025.

  • Cavallini E, Dunlosky J, Bottiroli S, Hertzog C, Vecchi T. Promoting transfer in memory training for older adults. Aging Clin Exp Res. 2010 Aug;22(4):314-23. doi: 10.3275/6704. Epub 2009 Nov 27.

  • Valentijn SA, van Hooren SA, Bosma H, Touw DM, Jolles J, van Boxtel MP, Ponds RW. The effect of two types of memory training on subjective and objective memory performance in healthy individuals aged 55 years and older: a randomized controlled trial. Patient Educ Couns. 2005 Apr;57(1):106-14. doi: 10.1016/j.pec.2004.05.002.

  • Rouse HJ, Small BJ, Faust ME. Assessment of Cognitive Training & Social Interaction in People with Mild to Moderate Dementia: A Pilot Study. Clin Gerontol. 2019 Jul-Sep;42(4):421-434. doi: 10.1080/07317115.2019.1590489. Epub 2019 Mar 21.

  • Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS. The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006 May;5(5):406-12. doi: 10.1016/S1474-4422(06)70417-3.

  • Ertel KA, Glymour MM, Berkman LF. Effects of social integration on preserving memory function in a nationally representative US elderly population. Am J Public Health. 2008 Jul;98(7):1215-20. doi: 10.2105/AJPH.2007.113654. Epub 2008 May 29.

  • Verhaeghen P, Marcoen A, Goossens L. Improving memory performance in the aged through mnemonic training: a meta-analytic study. Psychol Aging. 1992 Jun;7(2):242-51. doi: 10.1037//0882-7974.7.2.242.

  • Flynn TM, Storandt M. Supplemental group discussions in memory training for older adults. Psychol Aging. 1990 Jun;5(2):178-81. doi: 10.1037//0882-7974.5.2.178.

  • Chiu HF, Chan CK, Lam LC, Ng KO, Li SW, Wong M, Chan WF. The modified Fuld Verbal Fluency Test: a validation study in Hong Kong. J Gerontol B Psychol Sci Soc Sci. 1997 Sep;52(5):P247-50. doi: 10.1093/geronb/52b.5.p247.

  • Fairchild JK, Friedman L, Rosen AC, Yesavage JA. Which older adults maintain benefit from cognitive training? Use of signal detection methods to identify long-term treatment gains. Int Psychogeriatr. 2013 Apr;25(4):607-16. doi: 10.1017/S1041610212002049. Epub 2012 Dec 14.

  • Wechsler, D. (2008). Wechsler Adult Intelligence Scale-Fourth Edition: Administration and Scoring Manual. San Antonio, TX: Pearson Assessment.

    RESULT
  • Corsi, P. M. (1972). Human memory and the medial temporal region of the brain.

    RESULT

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Study Officials

  • Michal Lavidor, Prof.

    Department of Psychology, and the Gonda Brain Research center, Bar Ilan University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: The study included 32 subjects, 20 in the experimental group and 12 in the control group. The experimental group received 12 sessions of strategy-based cognitive training combined with a socially interactive learning method. The control group received the same number of meetings but without the strategy training. Participants were recruited from designated active groups in the community.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

August 17, 2021

First Posted

August 23, 2021

Study Start

November 18, 2018

Primary Completion

February 3, 2019

Study Completion

February 24, 2019

Last Updated

August 26, 2021

Record last verified: 2021-08

Data Sharing

IPD Sharing
Will not share

The datasets generated during and/or analyzed during the current study are available from the main author.

Locations