Lung Function After Abdominal Surgery

NCT04502420 | Completed

• 1 other identifier: 2018-223-31M
• Study Type: observational
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Investigation: The day before surgery and the day after surgery Primary outcome measures:

• Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
• PaO2, PaCO2 and oxygen saturation (blood gas)

Conditions

Lung Function; Postoperative Complications; Abdominal Surgery

Keywords

Lung function; Diffusion capacity; Postoperative complications; Abdominal surgery

Outcome Measures

Primary Outcomes (1)

• Diffusion capacity for carbon monoxide (DLCO)

  Change in DLCO

  Change from baseline (the day before surgery) to postoperative day 1 or 2

Secondary Outcomes (4)

• Vital capacity (VC)

  Change from baseline (the day before surgery) to postoperative day 1 or 2

• Forced expiratory volume (FEV1)

  Change from baseline (the day before surgery) to postoperative day 1 or 2

• Arterial PO2

  Change from baseline (the day before surgery) to postoperative day 1 or 2

• Arterial PCO2

  Change from baseline (the day before surgery) to postoperative day 1 or 2

Study Arms (1)

Abdominal surgery

People who to be operated in the abdomen are investigated before and after surgery.

Diagnostic Test: Lung function before and after surgery

Interventions

Lung function before and after surgery DIAGNOSTIC_TEST

A diagnostic test

Also known as: Diffusion capacity and arterial blood gas before and after surgery.

Abdominal surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients of 18 years old or olderundergoing abdominal surgery at department of Surgery, Urology and Gynecologi Umeå University hospital

You may qualify if:

• Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital.
• Must be able to perform a lung function test

You may not qualify if:

• Dementia or severe cognitive impairment

Sponsors & Collaborators

• Umeå University: lead
• Karolinska Institutet: collaborator

Study Sites (1)

Dept surgery,

Umeå, Sweden

Location

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Karl A Franklin, Prof

  Inst Surgical and periopertive sciences, Umeå university, Sweden

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 28, 2020
• First Posted: August 6, 2020
• Study Start: August 17, 2020
• Primary Completion: October 17, 2021
• Study Completion: October 17, 2021
• Last Updated: January 25, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)