NCT05556174|CompletedDMC
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
REMAIN-1
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REMAIN-1
Sponsor study identifier
interventional
1,060
1 country
1
Study Start
October 9, 2022
Actual (reported)Primary Completion
September 11, 2024
Actual (reported)Study Completion
November 11, 2024
Actual (reported)Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery. Several studies showed that intraoperative lung-protective ventilation with periodic lung recruitment maneuvers could reduce postoperative pulmonary complications. Other studies showed that intraoperative lung protective ventilation without periodic lung recruitment maneuvers could also reduce postoperative pulmonary complications. The purpose of this study was to compare the effects of the above two regimens on postoperative pulmonary complications.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 11, 2024
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 14, 2022
Actual (reported)September 27, 2022
Actual (reported)October 9, 2022
Actual (reported)September 11, 2024
Actual (reported)November 11, 2024
Actual (reported)Rate of respiratory failure
Respiratory failure: postoperative arterial partial pressure of oxygen (PaO2) \< 8 kPa (60 mmHg) on room air, a PaO2: Inhaled oxygen concentration (FI02) ratio \< 40 kPa (300 mmHg) or arterial oxyhaemoglobin saturation measured with pulse oximetry \< 90% and requiring oxygen therapy
Day 0 to 7 after surgery
Rate of mild respiratory failure
Day 0 to 7 after surgery
Rate of moderate respiratory failure
Day 0 to 7 after surgery
Rate of severe respiratory failure
Day 0 to 7 after surgery
Rate of sustained hypoxaemia
Day 0 to 7 after surgery
Rate of modified respiratory failure
Day 0 to 7 after surgery
Dead space rate
Intraoperative: after half an hour of mechanical ventilation, before the end of mechanical ventilation
intraoperative lung-protective ventilation with periodic lung recruitment maneuvers
intraoperative lung-protective ventilation without periodic lung recruitment maneuvers
lung recruitment maneuvers repeated every 30 minutes
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
The Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510655, China
Zhang NR, Zhang LZ, Chen Y, Zhang S, Li S, Gu XK, Li J, Li H. Intraoperative protective ventilation with or without periodic lung recruitment manoeuvres on pulmonary complications after major abdominal surgery (REMAIN-1): protocol for a randomised controlled trial. BMJ Open. 2025 Mar 13;15(3):e093360. doi: 10.1136/bmjopen-2024-093360.
Hong Li, MD
Sixth Affiliated Hospital, Sun Yat-sen University
1,060 participants (actual enrollment reported by the registry).
First Submitted
September 14, 2022
First Posted
September 27, 2022
Study Start
October 9, 2022
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GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery
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Primary Completion
September 11, 2024
Actual (reported)Study Completion
November 11, 2024
Actual (reported)Last Updated
January 3, 2025
Record last verified: 2024-11
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Source: ClinicalTrials.gov.
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