NCT04493177

Brief Summary

In order to evaluate the effect of an educational intervention on mothers with gestational diabetes and their offspring in the first 18 months of life, The intervention will be applied to mothers with gestational diabetes, and a group of mothers without diabetes, against a control group with the normal post-partum treatment. Effects on overweight and obesity will be evaluated in both mothers and offspring.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
645

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 17, 2020

Completed
13 days until next milestone

First Posted

Study publicly available on registry

July 30, 2020

Completed
26 days until next milestone

Study Start

First participant enrolled

August 25, 2020

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 25, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 25, 2025

Completed
Last Updated

September 28, 2023

Status Verified

September 1, 2023

Enrollment Period

5 years

First QC Date

July 17, 2020

Last Update Submit

September 26, 2023

Conditions

Outcome Measures

Primary Outcomes (2)

  • Prevention of overweight/obesity in offspring, determined by z-score in the indicator for weight for age

    Offspring will be expected to have a difference of at least 0,3 standard deviations in z-score of the indicator for weight for age, as measured by weight on a standard weight scale over the course of the study, and compared with WHO growth charts.

    18 months

  • Prevention of overweight/obesity mothers, determined by loss in body mass index (BMI)

    Mothers will be expected to have a loss of at least 1.8kg/m2 of body mass index (BMI, weight/height squared), as measured by weight, as measured by a standard weight scale, divided by height in meters squared over the course of the study.

    18 months

Secondary Outcomes (6)

  • Changes in blood concentration of glucose: GDM

    18 months

  • Changes in blood concentration of glucose: intervention

    18 months

  • Changes in blood concentration of glycosylated hemoglobin: GDM

    18 months

  • Changes in blood concentration of glycosylated hemoglobin: intervention

    18 months

  • Changes in blood concentration of lipids: GDM

    18 months

  • +1 more secondary outcomes

Study Arms (3)

Gestational diabetes intervention

EXPERIMENTAL

All mothers with gestational diabetes will receive 18 months of educational intervention post-partum. They and their offspring will be evaluated at months 1,2,3,6,9,12,15,and 18.

Behavioral: Educational interventionOther: Conventional treatment Guia de Practica Clinica IMSS-029-08

No diabetes intervention

EXPERIMENTAL

Mothers without gestational diabetes will receive 18 months of educational intervention post-partum. They and their offspring will be evaluated at months 1,2,3,6,9,12,15,and 18.

Behavioral: Educational interventionOther: Conventional treatment Guia de Practica Clinica IMSS-029-08

No diabetes no intervention

ACTIVE COMPARATOR

Mothers without gestational diabetes will receive the conventional care for 18 months post-partum. They and their offspring will be evaluated at months 1,2,3,6,9,12,15,and 18.

Other: Conventional treatment Guia de Practica Clinica IMSS-029-08

Interventions

Monthly 45-minute sessions will be held, including dietary, and physical activity modification, early stimulation, exclusive breastfeeding for 6 months and the proper introduction of foods, and other support for the mother. The sessions will be supported by personalized contact by WhatsApp and programmed telephone calls, in addition to conventional treatment.

Gestational diabetes interventionNo diabetes intervention

Conventional treatment includes some early stimulation, monthly visits for height/weight measurement of the offspring.

Gestational diabetes interventionNo diabetes interventionNo diabetes no intervention

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • years old
  • insured by IMSS
  • with or without gestational diabetes

You may not qualify if:

  • History of type 1 or 2 diabetes, MODY or secondary diabetes
  • CKD, hepatic or cardiac disease, pregnancy hypertension, corioamniotis orpremature membrane rupture, pulmonary maturity 24 hours before birth, severe complications

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital Gineco-Obstetrico #4

Mexico City, 06720, Mexico

Location

Related Publications (1)

  • Soto Briseno AI, Gomez-Diaz RA, Saldana Espinoza RC, Lavielle P, Valdez Gonzalez AL, Wacher NH. Validation of the COVID-19 Fear Scale modified for application during the perinatal period. J Psychosom Obstet Gynaecol. 2022 Dec;43(4):447-452. doi: 10.1080/0167482X.2022.2050210. Epub 2022 Mar 16.

MeSH Terms

Conditions

Diabetes, GestationalOverweightObesity

Interventions

Early Intervention, Educational

Condition Hierarchy (Ancestors)

Pregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Child Health ServicesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and ServicesPreventive Health Services

Study Officials

  • Cesar R Gonzalez Bonilla, PhD

    Secretary of Health

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
CARE PROVIDER
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 17, 2020

First Posted

July 30, 2020

Study Start

August 25, 2020

Primary Completion

August 25, 2025

Study Completion

August 25, 2025

Last Updated

September 28, 2023

Record last verified: 2023-09

Data Sharing

IPD Sharing
Will not share

Research will be shared upon written request.

Locations