Screening for Alcohol-related Cognitive Impairments in Cirrhotic Patients

NCT04490330 | Unknown

• 1 other identifier: PI2019_843_0106
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

80% of patients with alcohol use disorders (AUD) present cognitive impairments, such as memory and executive functions. These disorders may have repercussions in addiction treatment by altering the patient's adherence to care. The level of impairment is dependent on the onset of addiction, and also the duration of abstinence. A complete neuropsychological evaluation is necessary to highlight cognitive impairments. In practice, the evaluation of these disorders by practitioners, is done with the help of tools of screening like the MoCa (Montreal cognitive assesment) and the BEARNI (Brief evaluation of alcohol related neuropsychological impairment). However, none of these tools have been evaluated in patients with alcoholic cirrhosis. Indeed, some studies have suggested that liver disorders including cirrhosis may be a factor aggravating cognitive disorders. The purpose of this study is to evaluate the ability of the BEARNI tool to detect alcohol-related cognitive problems in patients with alcohol-related cirrhosis.

Conditions

Alcohol Dependence; Dependence; Cognitive Impairments; Cirrhosis; Liver Diseases

Keywords

Alcohol Dependence; Dependence; Cognitive Impairments; Cirrhosis; Liver Diseases

Outcome Measures

Primary Outcomes (1)

• number of alcoholic cirrhosis patients with presence of alcohol-related cognitive disorders

  the number of alcoholic cirrhosis patients with presence of alcohol-related cognitive disorders will be measured by using the BEARNI screening tool. BEARNI screening tool is Brief evaluation of alcohol related neuropsychological impairment.

  day 1

Interventions

questionnaire OTHER

AUDIT questionnaire (alcohol use disorders identification test)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with alcoholic cirrhosis will be evaluated with BEARNI tool in order to detect alcohol-related cognitive problems.

You may qualify if:

• Patient with cirrhosis
• patients with cirrhosis diagnosed by clinical examination
• patients with cirrhosis diagnosed by biological and / or morphological and / or noninvasive tests and / or liver biopsy
• CHILD A, B or C

You may not qualify if:

• hepatitis encephalopathy less than 6 months old
• complicated cirrhosis with hepatocellular carcinoma
• Acute alcoholic hepatitis
• viral cirrhosis

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80480, France

RECRUITING

MeSH Terms

Conditions

Alcoholism; Cognitive Dysfunction; Fibrosis; Liver Diseases

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Cognition Disorders; Neurocognitive Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Central Study Contacts

Bernard ANGERVILLE, MD

CONTACT

(33)322068297; angerville.bernard@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 24, 2020
• First Posted: July 29, 2020
• Study Start: August 1, 2020
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: February 8, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)