Retrospective Review on Patients With Recurrent Asthmatic Attacks Requiring Hospitalizations

NCT04479501 | Completed

• 1 other identifier: CREC 2017.503
• Study Type: observational
• Target: 2,280
• Locations: 1 country
• Sites: 1

Brief Summary

Asthma is a common respiratory disease. around the world. Asthma exacerbation is one of the major sequelae and associated with various morbidity and mortality. A satisfactory asthma control can help to bring down the risk of exacerbation and hence hospitalization. However, the real-world evidence on the clinical factors that leads to multiple admissions, when compared with single admission, due to asthma exacerbation is scarce. This study aimed at evaluating the clinical characteristics of patients who had single and multiple hospitalizations for asthma exacerbations, and exploring the risk factors that predict multiple hospitalizations.

Conditions

Asthma

Keywords

Asthma; Asthma exacerbation; Asthma hospitalization; Asthma control; Asthma care

Outcome Measures

Primary Outcomes (1)

• Number of patients who had hospitalization for asthma attack

  Number of patients who had hospitalization for asthma attack

  1 year

Secondary Outcomes (4)

• Burden of comorbidity among subjects with recurrent hospital admission for asthma attack

  1 year

• Spirometric parameters (FEV1, FVC) among subjects with recurrent hospital admission for asthma attack

  1 year

• Baseline blood eosinophil among subjects with recurrent hospital admission for asthma attack

  1 year

• Prevalence of asthma patients who had received phenotypic workup

  1 year

Study Arms (1)

Asthma group

Patients with asthma

Other: Asthma exacerbation related hospitalization

Interventions

Asthma exacerbation related hospitalization OTHER

Evaluate the difference between patients with single and multiple hospitalizations for asthma exacerbation

Asthma group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

By using the International Classification of Diseases, Ninth Revision, Clinical Modification code 493.xx, each participating hospital identified all primary hospital discharge diagnosis of asthma (exacerbation) during a 12-month period, between 1st January 2016 to 31st December 2016

You may qualify if:

• All patients with hospitalization for asthmatic exacerbation according to physician's clinical judgement
• Age greater than 18 years old

You may not qualify if:

• \- Inappropriate diagnosis of asthma exacerbation after evaluation

Sponsors & Collaborators

• Chinese University of Hong Kong: lead
• United Christian Hospital: collaborator
• Princess Margaret Hospital, Hong Kong: collaborator
• Pamela Youde Nethersole Eastern Hospital: collaborator
• Queen Elizabeth Hospital, Hong Kong: collaborator
• Queen Mary Hospital, Hong Kong: collaborator
• Kwong Wah Hospital: collaborator
• Tseung Kwan O Hospital, Hong Kong: collaborator
• Caritas Medical Centre, Hong Kong: collaborator
• North District Hospital, Hong Kong: collaborator
• Alice Ho Miu Ling Nethersole Hospital: collaborator

Study Sites (1)

Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

Related Publications (24)

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Related Links

• Assessed on 28 April 2017

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Ka Pang Chan, MBChB

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Honorary Clinical Tutor

Study Record Dates

• First Submitted: June 28, 2020
• First Posted: July 21, 2020
• Study Start: December 1, 2017
• Primary Completion: June 30, 2019
• Study Completion: December 31, 2019
• Last Updated: July 21, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Starting 6 months after publication
• Access Criteria: upon individual approach for metaanalysis or related study

Locations

HK (1)