NCT04477577

Brief Summary

The First Heroes study plans to influence weight and health trajectories, modify disease risk, and improve health care services for mother-father-infant triads from racial/ethnic minority and health disparity populations. This study is a two-arm, randomized controlled trial recruiting from Massachusetts General Hospital (MGH) obstetrics practices. This study will enroll 250 father-mother dyads in the second trimester of pregnancy and intervene through their offspring's 1-year birthday. Each mother-father dyad participating will be randomly assigned to one of two arms: 1. Obstetric and Pediatric Standard of Care + New Parent Engagement Intervention Arm or; 2. Obstetric and Pediatric Standard of Care + Safety Control Arm.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
657

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 8, 2020

Completed
12 days until next milestone

First Posted

Study publicly available on registry

July 20, 2020

Completed
15 days until next milestone

Study Start

First participant enrolled

August 4, 2020

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2023

Completed
Last Updated

November 24, 2025

Status Verified

April 1, 2024

Enrollment Period

3.3 years

First QC Date

July 8, 2020

Last Update Submit

November 19, 2025

Conditions

Keywords

OverweightObesitySocial Determinants of HealthMaternal-Child Health

Outcome Measures

Primary Outcomes (4)

  • Prevalence of rapid infant weight gain

    Weight-for-length z-score

    Birth to child age 6 months

  • Prevalence of rapid infant weight gain

    Weight-for-length z-score

    Birth to child age 12 months

  • Prevalence of overweight in infants

    Weight-for-length ≥97.7th percentile based on World Health Organization standards

    Birth to child age 12 months

  • Prevalence of overweight in infants

    Weight-for-length ≥95 percentile based on Center for Disease Control

    Birth to child age 12 months

Secondary Outcomes (20)

  • Maternal post-partum weight retention

    Child birth to 6-month postpartum

  • Maternal post-partum weight retention

    Child birth to 12-month postpartum

  • Maternal diet

    Baseline to 6-month postpartum

  • Maternal diet

    Baseline to 12-month postpartum

  • Maternal physical activity

    Baseline to 6-month postpartum

  • +15 more secondary outcomes

Other Outcomes (3)

  • Family enrollment in food assistance programs during intervention period

    Baseline to 12 months post partum

  • Family housing insecurity during intervention period

    Baseline to 12 months post partum

  • Family food insecurity during intervention period

    Baseline to 12 months post partum

Study Arms (2)

New Parent Intervention

EXPERIMENTAL
Behavioral: New Parent Intervention

Safety Control

ACTIVE COMPARATOR
Behavioral: Safety Control

Interventions

This arm will receive the Obstetric and Pediatric primary care provided within MGH obstetric and pediatric primary care practices, with additional active and targeted engagement of new parents by a health coach.

New Parent Intervention
Safety ControlBEHAVIORAL

This arm will receive the Obstetric and Pediatric primary care provided within MGH obstetric and pediatric primary care practices, with additional infant safety education materials.

Safety Control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Parental dyads must meet the following criteria:
  • Pregnant females and father of the baby, both aged ≥ 18 years
  • Singleton pregnancy
  • Planned involvement during the first year of the child's life
  • Planning to receive post-partum and pediatric care for child at any pediatric practice within the MassGeneral Brigham (Partners) Healthcare system
  • Ability to speak in English or Spanish
  • Capable of giving consent

You may not qualify if:

  • Dyads whose unborn child is found to have a severe defect or comorbidity upon 18-20 week ultrasound.
  • Mothers who intend on raising a child alone without any participation from the father of the child.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Related Publications (3)

  • Silver SR, Whooten RC, Kwete GM, Farrar-Muir H, Cournoyer RN, Barth EA, Kotelchuck M, Taveras EM. Stakeholder engagement in developing a father-inclusive early life obesity prevention intervention: First Heroes. BMC Pregnancy Childbirth. 2022 May 27;22(1):443. doi: 10.1186/s12884-022-04759-z.

    PMID: 35624421BACKGROUND
  • Whooten RC, Kwete GM, Farrar-Muir H, Cournoyer RN, Barth EA, Kotelchuck M, Taveras EM. Engaging fathers in the first 1000 days to improve perinatal outcomes and prevent obesity: Rationale and design of the First Heroes randomized trial. Contemp Clin Trials. 2021 Feb;101:106253. doi: 10.1016/j.cct.2020.106253. Epub 2020 Dec 17.

    PMID: 33340750BACKGROUND
  • Whooten RC, Kotelchuck M, Gonzalez AVC, Johnson N, Kwete G, Luo M, Muir HF, Barth EA, Smith N, Taveras EM. Expectant fathers' health behaviors, infant care intentions, and social-emotional wellbeing in the perinatal period: A latent class analysis and comparison to mothers. Prev Med Rep. 2023 Aug 26;36:102375. doi: 10.1016/j.pmedr.2023.102375. eCollection 2023 Dec.

    PMID: 37719794BACKGROUND

MeSH Terms

Conditions

Pediatric ObesityOverweightObesityMotor ActivityFeeding Behavior

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehaviorBehavior, Animal

Study Officials

  • Elsie Taveras, MD

    Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Division Chief

Study Record Dates

First Submitted

July 8, 2020

First Posted

July 20, 2020

Study Start

August 4, 2020

Primary Completion

November 30, 2023

Study Completion

November 30, 2023

Last Updated

November 24, 2025

Record last verified: 2024-04

Data Sharing

IPD Sharing
Will not share

Locations