NCT04462094|Completed
Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy
PRO-Ketamine
Loading search results
PRO-Ketamine
Sponsor study identifier
Secondary identifiers
OTHER · Committee of Ethical Research of Udayana University
interventional
68
1 country
1
Study Start
July 27, 2020
Actual (reported)Primary Completion
September 30, 2020
Actual (reported)Study Completion
November 10, 2020
Actual (reported)The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and proinflammatory cytokines play a joint regulatory role, i.e., increased production of proinflammatory cytokines can worsen the pain. Major surgery can trigger the release of cytokines such as IL-1, IL-6, and TNF-α.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 10, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 26, 2020
Actual (reported)July 8, 2020
Actual (reported)July 27, 2020
Actual (reported)September 30, 2020
Actual (reported)November 10, 2020
Actual (reported)Serum CRP level
Serum C-reactive protein level
1-hour before surgery
Serum CRP level
Serum C-reactive protein level
24-hours after surgery
serum neutrophil-count
serum neutrophil-count (from a complete blood count test)
1-hour before surgery
serum neutrophil-count
serum neutrophil-count (from a complete blood count test)
24-hours after surgery
Low-dose ketamine (0.3 mg/kg) in 3 ml normal saline solution given at the end of surgery
Low-dose ketamine (0.3 mg/kg) in 3 ml normal saline solution given at induction
Ketamine 0.3 mg/kg at end-of-surgery (intravenously)
Ketamine 0.3 mg/kg at anesthesia induction (intravenously)
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Treatment programme
Ketamine 0.3 mg/kg at anesthesia induction
The registry describes a treatment programme. Individual components, doses and actual administration are not established by this entry.
View registry recordSanglah General Hospital
Denpasar, Bali, 80114, Indonesia
Tjokorda GA Senapathi, Dr
Udayana University
Christopher Ryalino, Dr
Udayana University
Made SP Adi, Dr
Udayana University
68 participants (actual enrollment reported by the registry).
First Submitted
June 26, 2020
First Posted
July 8, 2020
VAS (visual analog score)
minimum=0; maximum=10; higher score corresponds to more severe pain
first 24 hours after the surgery
morphine consumption (mg)
total morphine consumption in 24 hours after the surgery
first 24 hours after the surgery
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Study Start
July 27, 2020
Actual (reported)Primary Completion
September 30, 2020
Actual (reported)Study Completion
November 10, 2020
Actual (reported)Last Updated
November 12, 2020
Record last verified: 2020-11
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: