Effects of Calamansi on Blood Glucose

NCT04462016 | Completed

• 1 other identifier: MDP20505_2017/2018_MS0001
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

It is important to bring the blood glucose levels of those with type 2 diabetes mellitus (T2DM) back to normal levels as this can stop the condition from worsening and prevent other conditions that are related to T2DM from developing. One way to maintain healthy blood glucose level is the use of the glycaemic index (GI), which ranks food according to how the body responds to its carbohydrate content. Low GI foods corresponds to low increase in blood glucose levels. Calamansi is a citrus that is believed not to induce an increase in blood glucose levels. Since beverages from calamansi are available and diabetes is a health concern in the community, it is important to investigate the effect of consuming this drink. Finger prick blood were tested in order to obtain the blood glucose levels for calculating the GI for the calamansi drink.

Conditions

Blood Glucose Response

Keywords

calamansi; glycaemic index; post-prandial blood glucose

Outcome Measures

Primary Outcomes (1)

• Change from baseline blood glucose levels

  Capillary blood glucose using glucometer

  30, 60, 90, 120 min after drinking

Secondary Outcomes (1)

• Change from baseline urinary glucose levels

  30, 60, 90, 120 min after drinking

Study Arms (2)

Reference drink

ACTIVE COMPARATOR

Healthy volunteers' blood glucose response to reference drink (glucose)

Other: Glucose

Test drink

EXPERIMENTAL

Healthy volunteers' blood glucose response to test drink (calamansi)

Other: Calamansi

Interventions

Calamansi OTHER

250 ml of a commercially sourced calamansi drink

Test drink

Glucose OTHER

75 g of glucose dissolved in 250 ml of drinking water

Reference drink

Eligibility Criteria

• Age: 18 Years - 21 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• non-smoker
• BMI between 18.5 and 24.99 kg/m2
• waist circumference less than 102 cm
• random blood glucose less than 7.8 mmol/L
• negative urine dipstick result
• not on any medications
• no family history of inherited diseases
• no heart conditions (angina, arrhythmia or heart failure)
• no history of acute medical or surgical event within the past 6 months.

You may not qualify if:

• pre-existing conditions such as HIV, hepatitis, inflammatory bowel diseases, diabetes mellitus, kidney disease, blood disorders (such as thalassaemia)

Sponsors & Collaborators

• University Malaysia Sarawak: lead

Study Sites (1)

Faculty of Medicine and Health Sciences

Kuching, Sarawak, 94300, Malaysia

Location

Related Publications (1)

• Siner A, Sevanesan MS, Ambomai T, Abd Wahab Z, Lasem L. Blood glucose response to a calamansi drink in healthy adults: a non-randomised study. BMC Res Notes. 2020 Aug 28;13(1):404. doi: 10.1186/s13104-020-05250-8.

  PMID: 32859257 DERIVED

MeSH Terms

Interventions

Glucose

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Angela Siner, PhD

  Universiti Malaysia Sarawak

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 1, 2020
• First Posted: July 8, 2020
• Study Start: February 2, 2018
• Primary Completion: May 6, 2018
• Study Completion: August 8, 2018
• Last Updated: July 8, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: This will be made available starting 6 months from the date of publication; for the next 5 years.
• Access Criteria: Through reasonable request to the corresponding author.

Locations

MY (1)