Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin Conditions and Inflammatory Related Factors

NCT04456829 | Completed

• 1 other identifier: 20-0-54-B
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood

Conditions

Skin Conditions; Proinflammatory Cytokines

Outcome Measures

Primary Outcomes (11)

• The change of skin moisture

  Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

  0, 4, and 8 weeks

• The change of skin elasticity

  Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves

  0, 4, and 8 weeks

• The change of skin wrinkles

  VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units

  0, 4, and 8 weeks

• The change of skin collagen density

  DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score

  0, 4, and 8 weeks

• The change of skin texture

  VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

  0, 4, and 8 weeks

• The change of skin pores

  VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units

  0, 4, and 8 weeks

• The change of total antioxidant capacity of blood

  Total Antioxidant Capacity Assay Kit

  0 and 8 weeks

• The change of TNF-alpha of blood

  ELISA Kit

  0 and 8 weeks

• The change of IL-6 of blood

  ELISA Kit

  0 and 8 weeks

• The change of IL-17 of blood

  ELISA Kit

  0 and 8 weeks

• The change of IL-1β of blood

  ELISA Kit

  0 and 8 weeks

Study Arms (2)

Resveratrol drink

EXPERIMENTAL

Dietary Supplement: Resveratrol drink

Placebo drink

PLACEBO COMPARATOR

Dietary Supplement: Placebo drink

Interventions

Resveratrol drink DIETARY_SUPPLEMENT

Subjects will consume a bottle of resveratrol drink for two months.

Also known as: Grape Yeast Compound Fruit Vegetable Beverage

Resveratrol drink

Placebo drink DIETARY_SUPPLEMENT

Subjects will consume a bottle of placebo drink for two months.

Placebo drink

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteers aged above 20 years old

You may not qualify if:

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
• Subjects who have large spots (area \>3 square centimeter) or abnormal acne.

Sponsors & Collaborators

• TCI Co., Ltd.: lead

Study Sites (1)

Chia Nan University of Pharmacy & Science

Tainan, 71710, Taiwan

Location

MeSH Terms

Conditions

Skin Diseases

Condition Hierarchy (Ancestors)

Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2020
• First Posted: July 7, 2020
• Study Start: September 17, 2020
• Primary Completion: November 10, 2020
• Study Completion: December 31, 2020
• Last Updated: January 15, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)