NCT04451473

Brief Summary

Objective: The adoption of Enhanced Recovery Surgery programs in lung resection is relatively recent with limited outcome data. This study aimed to determine the impact of an Enhanced Recovery Surgery pathway on short- term and long- term results in patients undergoing lung resection for primary lung cancer. Methods: A Randomized Controlled Trial was designed to collect the perioperative data on consecutive patients undergoing lung resection for primary lung cancer. Patients will be randomizely assigned to the ERAS- Group and Control- Group. Short-term and long- term effect will be compared between the two groups.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
350

participants targeted

Target at P75+ for not_applicable lung-cancer

Timeline
13mo left

Started Oct 2019

Longer than P75 for not_applicable lung-cancer

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress86%
Oct 2019Jun 2027

Study Start

First participant enrolled

October 8, 2019

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

June 27, 2020

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 30, 2020

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2023

Completed
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2027

Expected
Last Updated

November 16, 2022

Status Verified

February 1, 2022

Enrollment Period

3.7 years

First QC Date

June 27, 2020

Last Update Submit

November 14, 2022

Conditions

Outcome Measures

Primary Outcomes (6)

  • intensive care unit utilization

    the time in intensive care unit utilization

    within 4 days after surgery

  • the degree of pain

    Visual Analogue Scale/Score

    within 4 days after surgery

  • the time of ambulation

    the time after surgery that patients could leave the bed and walk

    within 48 hours after surgery

  • the time for oral feed

    the time for oral feed

    within 48 hours after surgery

  • the time of hospitalization

    the time of hospitalization

    within 5 days after surgery

  • complications

    the rate of complications

    within 7 days after surgery

Secondary Outcomes (2)

  • disease- free survival

    within 5 years after surgery

  • overall survival

    within 10 years after surgery

Study Arms (2)

ERAS- Group

EXPERIMENTAL

Patients underwent surgery for lung cancer accepted the enhanced recovery after surgery (ERAS).

Procedure: Enhanced Recovery After Surgery (ERAS )

Control- Group

OTHER

Patients underwent surgery for lung cancer without enhanced recovery after surgery (ERAS).

Procedure: Traditional perioperative management without Enhanced Recovery After Surgery (ERAS )

Interventions

the treatment of procedure according to Guidelines for enhanced recovery after lung surgery: recommendations of the ERAS Society and the ESTS

ERAS- Group

the treatment of procedure not abiding Guidelines for enhanced recovery after lung surgery

Control- Group

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Yunpeng Zhao

Jinan, Shandong, 250033, China

RECRUITING

Related Publications (1)

  • Ding Y, Zhou L, Shan L, Zhang W, Li P, Cong B, Tian Z, Zhao Y, Zhao X. Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study. Front Oncol. 2024 Nov 8;14:1474438. doi: 10.3389/fonc.2024.1474438. eCollection 2024.

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Enhanced Recovery After Surgery

Condition Hierarchy (Ancestors)

Respiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Perioperative CareSurgical Procedures, Operative

Study Officials

  • Xiaogang Zhao, Doctor

    The Second Hospital of Shandong University

    STUDY DIRECTOR

Central Study Contacts

Yunpeng Zhao, Doctor

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 27, 2020

First Posted

June 30, 2020

Study Start

October 8, 2019

Primary Completion

June 30, 2023

Study Completion (Estimated)

June 30, 2027

Last Updated

November 16, 2022

Record last verified: 2022-02

Locations