Effect of Ethnicity on Changes in VO2max and Cardiac Output in Response to Short-Term High Intensity Interval Training

NCT04449016 | Completed DMC

• 1 other identifier: 1200680-2
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to determine if ethnicity alters training responsiveness to a low dose of high intensity interval training in inactive women.

Conditions

Improved VO2max and Cardiac Output in Response to Training

Keywords

HIIT; Inactive; Women

Outcome Measures

Primary Outcomes (2)

• Change in baseline in VO2max at 3 weeks

  Each participant performed VO2max testing on an electronically-braked cycle ergometer using a ramp protocol. During exercise, subjects expired through a plastic mouthpiece and low resistance valve into tubing connected to a mixing chamber. Measures of ventilation and expired fractions of oxygen and carbon dioxide were obtained throughout exercise by a metabolic cart. Gas exchange data including VO2, VCO2, and ventilation were time-averaged every 15 seconds. The test was terminated when the subject's pedal cadence was below 50 rev/min.

  3 weeks

• Change in baseline in cardiac output max at 3 weeks

  During the VO2max assessment, participants wore a thoracic impedance device to measure heart rate and stroke volume, calculating their cardiac output.

  3 weeks

Study Arms (2)

Caucasian

EXPERIMENTAL

Participants performed 9 sessions of HIIT over 3 weeks, utilizing progressive overload by increasing the number of bouts by 1 each week. They started with 8 bouts on week 1, 9 bouts on week 2, and 10 bouts on week 3.

Other: High intensity interval training

Hispanic

EXPERIMENTAL

Participants performed 9 sessions of HIIT over 3 weeks, utilizing progressive overload by increasing the number of bouts by 1 each week. They started with 8 bouts on week 1, 9 bouts on week 2, and 10 bouts on week 3.

Other: High intensity interval training

Interventions

High intensity interval training OTHER

Repeated, brief, and intense exercise bouts separated by active recovery

Caucasian; Hispanic

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Women
• Between the age of 18-45
• Healthy and non-obese (BMI \< 30 kg/m2)
• Perform less than 150 minutes per week of exercise in the last 12 months
• % Caucasian or 100% Hispanic

You may not qualify if:

• Injured
• Obese
• Active
• Mixed ethnicity

Sponsors & Collaborators

• California State University, San Marcos: lead

Study Sites (1)

California State University San Marcos

San Marcos, California, 92096, United States

Location

Related Publications (7)

• Raleigh JP, Giles MD, Scribbans TD, Edgett BA, Sawula LJ, Bonafiglia JT, Graham RB, Gurd BJ. The impact of work-matched interval training on V̇O2peak and V̇O2 kinetics: diminishing returns with increasing intensity. Appl Physiol Nutr Metab. 2016 Jul;41(7):706-13. doi: 10.1139/apnm-2015-0614. Epub 2016 Feb 29.

  PMID: 27337599 BACKGROUND

• Astorino TA, White AC, Dalleck LC. Supramaximal testing to confirm attainment of VO2max in sedentary men and women. Int J Sports Med. 2009 Apr;30(4):279-84. doi: 10.1055/s-0028-1104588. Epub 2009 Feb 6.

  PMID: 19199208 BACKGROUND

• Astorino TA, Schubert MM, Palumbo E, Stirling D, McMillan DW, Cooper C, Godinez J, Martinez D, Gallant R. Magnitude and time course of changes in maximal oxygen uptake in response to distinct regimens of chronic interval training in sedentary women. Eur J Appl Physiol. 2013 Sep;113(9):2361-9. doi: 10.1007/s00421-013-2672-1. Epub 2013 Jun 11.

  PMID: 23754097 BACKGROUND

• Bowdon M, Marcovitz P, Jain SK, Boura J, Liroff KG, Franklin BA. Exercise Training in "At-Risk" Black and White Women: A Comparative Cohort Analyses. Med Sci Sports Exerc. 2018 Jul;50(7):1350-1356. doi: 10.1249/MSS.0000000000001580.

  PMID: 29462100 BACKGROUND

• Gill JM, Celis-Morales CA, Ghouri N. Physical activity, ethnicity and cardio-metabolic health: does one size fit all? Atherosclerosis. 2014 Feb;232(2):319-33. doi: 10.1016/j.atherosclerosis.2013.11.039. Epub 2013 Nov 23.

  PMID: 24468145 BACKGROUND

• Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, Kraus WE. Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis. 2004 Oct;176(2):371-7. doi: 10.1016/j.atherosclerosis.2004.05.018.

  PMID: 15380461 BACKGROUND

• Skinner JS, Jaskolski A, Jaskolska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C; HERITAGE Family Study. Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol (1985). 2001 May;90(5):1770-6. doi: 10.1152/jappl.2001.90.5.1770.

  PMID: 11299267 BACKGROUND

MeSH Terms

Conditions

Sedentary Behavior

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Todd Astorino, PhD

  California State University, San Marcos

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, FACSM

Model Details: This study was a longitudinal, repeated measures between subjects design.

Study Record Dates

• First Submitted: June 24, 2020
• First Posted: June 26, 2020
• Study Start: June 1, 2017
• Primary Completion: December 22, 2019
• Study Completion: March 23, 2020
• Last Updated: June 26, 2020

Record last verified: 2020-06

Locations

US (1)